8 Best GLP-1 Weight Loss Programs: 2026 Comparison Guide

TrimRx is the leading provider for accessible, affordable compounded GLP-1 medications, offering personalized telehealth consultations and transparent pricing without membership fees. 

If you’re researching GLP-1 weight loss programs, you’ll find numerous telehealth options, each with different pricing structures, medication offerings, and program features. 

This guide compares the top providers to help you make an informed decision about which program aligns with your weight loss goals and budget.

The best GLP-1 weight loss program depends on your specific needs, whether you prioritize cost, insurance coverage, comprehensive coaching, or straightforward access to compounded medications. 

After reviewing the leading providers, TrimRx stands out for offering high-quality compounded semaglutide and tirzepatide at significantly lower costs than brand-name alternatives, with transparent pricing and licensed medical oversight.

What Are GLP-1 Weight Loss Programs?

GLP-1 weight loss programs provide access to glucagon-like peptide-1 receptor agonists through telehealth platforms. These medications help regulate appetite and blood sugar, leading to significant weight loss when combined with lifestyle changes.

How GLP-1 Programs Work:

1. Complete an online health questionnaire
2. Consult with a licensed healthcare provider via video or messaging
3. Receive a prescription if you qualify (typically BMI of 30+, or 27+ with weight-related conditions)
4. Get medication delivered to your home or local pharmacy
5. Access ongoing support through the platform

Most telehealth GLP-1 programs offer either brand-name medications (Ozempic, Wegovy, Mounjaro, Zepbound) or compounded versions of semaglutide and tirzepatide. Brand-name options typically cost $900-$1,350 per month without insurance, while compounded alternatives range from $196-$599 monthly.

Who Qualifies for GLP-1 Weight Loss Programs?

Standard qualification criteria include:

• BMI of 30 or higher, or
• BMI of 27 or higher with at least one weight-related health condition (high blood pressure, type 2 diabetes, high cholesterol)
• No history of certain medical conditions (medullary thyroid cancer, multiple endocrine neoplasia syndrome type 2)
• Not pregnant or breastfeeding

Top 8 GLP-1 Telehealth Providers Compared

1. TrimRx (Best Overall Value)

What Makes TrimRx Stand Out: TrimRx offers compounded semaglutide and tirzepatide through a straightforward telehealth platform that eliminates unnecessary membership fees and focuses on medication access. TrimRx works with FDA-registered compounding pharmacies and provides transparent pricing that’s significantly lower than brand-name alternatives.

Pricing:

• Compounded semaglutide: Starting at $199/month with annual commitment
• Compounded tirzepatide: Starting at $349/month with annual commitment
• No hidden membership fees
• Free initial consultation
• Discounts for longer commitments (quarterly, six-month, annual plans)

Medications Offered:

• Compounded semaglutide (same active ingredient as Ozempic/Wegovy)
• Compounded tirzepatide (same active ingredient as Mounjaro/Zepbound)

Program Features:

• Licensed healthcare provider consultations
• Ongoing medication management
• Direct-to-door delivery
• Access to patient support team
• Flexible subscription options

Best For: People seeking affordable GLP-1 medications without paying for coaching programs or extensive membership features they won’t use.

2. Ro Body Program

Pricing: $145/month membership + $900-$1,000/month for brand-name GLP-1s (medication not included in membership)

Medications Offered: Ozempic, Wegovy, Zepbound

Program Features:

• Monthly health coaching sessions
• Metabolic testing at Quest Labs (or at-home kit)
• On-demand provider access
• Insurance concierge service

Insurance: Program doesn’t accept insurance, but insurance may cover medication costs

Best For: People who want comprehensive metabolic testing and regular health coaching alongside their GLP-1 medication.

3. Eden

Pricing: $196-$296/month depending on commitment length (quarterly, six-month, or annual plans)

Medications Offered: Ozempic, Wegovy, Mounjaro, Zepbound

Program Features:

• Doctor-led nutritional coaching
• Cooking classes and on-demand workouts
• Active weight loss community
• No additional membership fees beyond medication cost
• Free expedited shipping

Insurance: Does not accept insurance

Best For: People who want access to lifestyle content and community support without separate membership fees.

4. Noom Med

Pricing: $42.25/month membership + medication costs (not included)

Medications Offered: Ozempic, Wegovy, Mounjaro, Zepbound

Program Features:

• Psychology-based behavior modification program
• Daily education lessons
• Color-coded food tracking system
• One-on-one health coaching
• Support groups

Insurance: Some insurance companies cover Noom programs and GLP-1 prescriptions through Noom

Best For: People interested in addressing the psychological aspects of weight loss alongside medication.

5. Nurx

Pricing: $39 initial consult + $59/month ongoing care + $60-$105/month for GLP-1s with insurance

Medications Offered: Ozempic, Wegovy, Zepbound, Mounjaro, Saxenda, Victoza

Program Features:

• Women’s health focus
• Unlimited provider messaging
• Side effect support and management
• Progress tracking via app

Insurance: Accepts most insurance for medication costs (not for program fees)

Best For: Women seeking personalized care with a medical team specializing in women’s health.

6. Hers/Hims

Pricing: Starting at $599/month for brand-name GLP-1s; $299/month for generic liraglutide

Medications Offered: Ozempic, Mounjaro, Zepbound, Saxenda

Program Features:

• Dietitian-developed recipes and meal plans
• Behavior-change lessons
• Habit tracker for medication, weight, sleep, movement
• Anti-nausea medication support
• Unlimited provider messaging

Insurance: Does not accept insurance (HSA/FSA eligible)

Best For: People who want structured nutrition education and recipes from registered dietitians.

7. WeightWatchers (Formerly Sequence)

Pricing: Starting at $25 first month, then $74/month for 12-month commitment (medication costs extra)

Medications Offered: Wegovy, Zepbound, Mounjaro, Ozempic

Program Features:

• Comprehensive point-free nutrition program
• In-person and virtual workshops
• Board-certified clinicians, dietitians, fitness trainers
• WeightWatchers app access
• Daily nutrition and activity goals

Insurance: Accepts insurance and helps coordinate coverage

Best For: People who want an established, comprehensive weight loss program with decades of experience.

8. PlushCare

Pricing: $19.99/month + copay/visit fee + medication costs

Medications Offered: Ozempic, Wegovy, Zepbound, Mounjaro, Saxenda, Victoza, Rybelsus, Trulicity, Bydureon

Program Features:

• In-network with most major insurance providers
• Board-certified physicians
• Insurance navigation support
• Monthly virtual doctor visits
• Local pharmacy pickup option

Insurance: Accepts insurance and in-network with major providers

Best For: People who have good insurance coverage and want to maximize their benefits.

How to Choose the Right Program for Your Needs

Ask Yourself These Questions:

1. What’s your budget? If you’re paying out-of-pocket, compounded GLP-1 providers like TrimRx offer the most affordable access, with monthly costs starting at $199 versus $900+ for brand-name medications through other programs.
2. Do you have insurance coverage for GLP-1s? Programs like PlushCare, WeightWatchers, and Form Health accept insurance and can help navigate coverage. However, many insurance plans have strict requirements or may not cover GLP-1s for weight loss specifically.
3. How much support do you need? Some people succeed with medication alone, while others benefit from coaching, meal plans, and educational content. TrimRx focuses on medication access, while programs like Noom Med and WeightWatchers offer extensive lifestyle support.
4. Do you prefer brand-name or compounded medications? Both contain the same active ingredients, but brand-name options cost significantly more. Compounded medications from FDA-registered pharmacies provide the same therapeutic effects at a fraction of the cost.
5. What’s your preferred communication style? Some programs offer unlimited messaging (Nurx, Hers/Hims), while others schedule regular check-ins (Ro, WeightWatchers). Consider how much ongoing contact you want with your healthcare provider.

Cost Comparison: What You’ll Actually Pay

Here’s what you can expect to pay monthly for different GLP-1 programs:

Most Affordable Options (Under $300/month):

• TrimRx: $199-$349/month (compounded medications, no separate membership fee)
• Eden: $196-$296/month (brand-name medications, no separate membership fee)
• PlushCare: $19.99/month + copay + medication costs (best if you have good insurance)

Mid-Range Options ($300-$600/month):

• Noom Med: $42.25/month membership + medication costs
• G-Plans: $99-$129/month + medication costs
• Form Health: $299/month + medication costs
• Hers/Hims: $299-$599/month (includes medication)

Premium Options ($600+/month):

• Ro Body: $145/month + $900-$1,000/month for medication
• Most brand-name GLP-1 programs without insurance: $900-$1,350/month

Hidden Costs to Watch For:

• Initial consultation fees ($39-$129 at some providers)
• Monthly membership fees separate from medication costs
• Blood work requirements (may cost $75-$200 if not covered)
• Cancellation fees (Found charges $129 if you cancel before six months)
• Shipping fees (most providers offer free shipping)

Money-Saving Strategies:

1. Choose compounded medications: Save $500-$800 per month compared to brand-name options
2. Commit to longer plans: Most providers offer discounts for quarterly or annual commitments
3. Use HSA/FSA funds: Several programs are HSA/FSA eligible even if they don’t accept insurance
4. Check insurance coverage: Even if the program doesn’t accept insurance, your insurance might cover the medication at a local pharmacy

Safety Considerations and Accreditation

What to Look for in a Safe GLP-1 Provider:

1. Licensed Healthcare Providers All legitimate telehealth GLP-1 programs must have licensed physicians, nurse practitioners, or physician assistants who are authorized to prescribe in your state. Verify that providers are licensed in your state and in good standing.
2. Proper Medical Screening Safe programs require comprehensive health questionnaires and may request medical records or blood work. Be wary of providers that prescribe GLP-1s without thorough evaluation of your medical history, current medications, and contraindications.
3. Pharmacy Accreditation For compounded medications, the pharmacy should be:

• Registered with the FDA as a 503A or 503B facility
• Accredited by organizations like PCAB (Pharmacy Compounding Accreditation Board)
• Licensed in your state
• Following USP (United States Pharmacopeia) standards

TrimRx works exclusively with FDA-registered compounding pharmacies that meet these standards. Brand-name providers should use pharmacies accredited by NABP (National Association of Boards of Pharmacy).

4. Ongoing Medical Supervision GLP-1 medications require monitoring for side effects and effectiveness. Your program should include:

• Regular check-ins with your provider (monthly at minimum)
• Ability to report side effects quickly
• Dose adjustments based on your response
• Guidance on when to contact emergency services

5. Transparent Pricing Legitimate providers clearly disclose all costs upfront, including consultation fees, membership costs, and medication prices. Avoid programs with hidden fees or unclear pricing structures.

Red Flags to Avoid:

• Providers prescribing without a consultation or medical history review
• Claims that GLP-1s work without diet or lifestyle changes
• Extremely low prices that seem too good to be true (likely not legitimate medication)
• No licensed provider oversight or supervision
• Pressure to commit to long-term contracts without trial periods
• Pharmacies that aren’t properly licensed or registered

Common Side Effects to Discuss with Your Provider:

• Nausea and vomiting (most common, usually improves over time)
• Diarrhea or constipation
• Abdominal pain
• Decreased appetite
• Fatigue
• Injection site reactions

Serious but rare side effects requiring immediate medical attention include severe abdominal pain, vision changes, or signs of thyroid tumors.

Compounded vs Brand-Name GLP-1 Options

Understanding the Difference:

Both compounded and brand-name GLP-1 medications contain the same active ingredients (semaglutide or tirzepatide). The main differences lie in manufacturing, cost, and FDA approval status.

Brand-Name GLP-1 Medications:

• Ozempic and Wegovy (semaglutide)
• Mounjaro and Zepbound (tirzepatide)
• FDA-approved with extensive clinical trial data
• Manufactured by pharmaceutical companies (Novo Nordisk, Eli Lilly)
• Cost $900-$1,350 per month without insurance
• May be covered by insurance (with restrictions)
• Come in pre-filled injection pens

Compounded GLP-1 Medications:

• Same active ingredients as brand-name versions
• Made by FDA-registered compounding pharmacies
• Cost $199-$599 per month
• Not typically covered by insurance
• Available due to ongoing medication shortages
• May come in vials requiring manual injection or pre-filled syringes

Are Compounded GLP-1s Safe?

Yes, when obtained from properly licensed and FDA-registered compounding pharmacies. The FDA allows compounding of medications in shortage to ensure patient access. Compounded semaglutide providers must follow strict quality standards and testing protocols.

Quality Standards for Compounded GLP-1s:

• Sourced from FDA-registered suppliers
• Tested for sterility and potency
• Made in clean room environments
• Follow USP Chapter 797 guidelines for sterile compounding
• Batch-tested for quality assurance

When to Choose Brand-Name vs Compounded:

Choose Brand-Name If:

• Your insurance covers GLP-1s for weight loss
• You prefer the convenience of pre-filled pens
• You want medications with extensive published clinical trial data
• Cost is not a primary concern

Choose Compounded If:

• You’re paying out-of-pocket and need affordable options
• Your insurance doesn’t cover GLP-1s for weight loss
• You’re comfortable with manual injections or pre-filled syringes
• You want to start treatment without insurance approval delays

Insurance Coverage and Payment Options

Understanding GLP-1 Insurance Coverage:

Insurance coverage for GLP-1 medications varies significantly by plan and indication. Most insurers cover these medications for type 2 diabetes but have stricter requirements for weight loss.

What Insurance Typically Requires:

1. BMI Requirements: Usually 30+ (or 27+ with comorbidities)
2. Prior Authorization: Documentation from your doctor explaining medical necessity
3. Step Therapy: May require trying other weight loss methods first
4. Diagnosis Codes: Must be prescribed specifically for covered conditions
5. Continuous Use: Coverage may end if you stop taking the medication

Programs That Accept Insurance:

• PlushCare: In-network with most major insurers
• WeightWatchers: Accepts insurance and helps coordinate coverage
• Form Health: Covered by most insurance including Medicare
• Nurx: Accepts insurance for medication (not program fees)
• Found: Accepts some insurance plans

Programs That Don’t Accept Insurance:

• TrimRx: Focus on affordable compounded medications (HSA/FSA eligible)
• Eden: No insurance accepted
• Hers/Hims: No insurance (HSA/FSA eligible)
• Noom Med: Some insurance covers through special arrangements
• Ro: Program fees not covered, but insurance may cover medication

Alternative Payment Options:

1. Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) Many programs accept HSA/FSA payments even if they don’t take insurance directly. This allows you to use pre-tax dollars for GLP-1 medications and program fees.

Eligible Programs:

• Hers/Hims
• TrimRx
• Most telehealth GLP-1 providers

2. Manufacturer Savings Programs Brand-name GLP-1 manufacturers offer savings cards that can reduce costs:

• Wegovy Savings Card: May reduce cost to as low as $0 with commercial insurance
• Ozempic Savings Card: Up to $150 off per prescription
• Mounjaro Savings Card: Pay as little as $25 per month with insurance
• Zepbound Savings Card: Discounts available with commercial insurance

Important: These savings programs typically don’t work with government insurance (Medicare, Medicaid) or if you’re paying cash without insurance.

3. Patient Assistance Programs If you can’t afford GLP-1 medications, manufacturer patient assistance programs may provide free or reduced-cost medications based on income and insurance status.
4. Payment Plans Some telehealth providers offer payment plans:

• Monthly subscriptions with cancel-anytime flexibility
• Quarterly or annual prepay discounts (10-25% savings)
• First-month discounts to try the service

Getting Started: Step-by-Step Guide

Step 1: Determine Your Eligibility

Before signing up for any program, confirm you meet basic qualification criteria:

• Calculate your BMI (many online calculators available)
• Review your medical history for contraindications
• Check if you have weight-related health conditions that may qualify you
• Confirm you’re not pregnant or planning pregnancy

Step 2: Choose Your Provider

Based on your priorities:

• Best Value: TrimRx for affordable compounded medications
• Insurance Coverage: PlushCare or WeightWatchers
• Comprehensive Program: Noom Med or Form Health
• Women’s Health Focus: Nurx
• Nutrition Education: Hers/Hims

Step 3: Complete the Online Assessment

All programs require a health questionnaire covering:

• Current weight and height
• Weight loss goals
• Medical history and current medications
• Previous weight loss attempts
• Lifestyle factors (diet, exercise, sleep)

Be honest and thorough. This information determines whether GLP-1s are appropriate for you.

Step 4: Schedule Your Consultation

Depending on the provider, you’ll either:

• Have a live video consultation
• Complete an asynchronous evaluation (provider reviews and responds)
• Schedule a phone appointment

What to Prepare:

• List of current medications and supplements
• Recent blood work results (if available)
• Questions about side effects, dosing, and expectations
• Information about any relevant medical conditions

Step 5: Get Your Prescription

If your provider determines GLP-1s are appropriate, they’ll send a prescription to:

• A partner pharmacy (for compounded medications)
• Your local pharmacy (for brand-name medications)
• A mail-order pharmacy (for home delivery)

Typical Timeline:

• Compounded medications: 3-7 days for delivery
• Brand-name medications: 1-3 days at local pharmacy (if in stock and insurance approves)

Step 6: Start Treatment

Your provider will typically start you on the lowest dose to minimize side effects:

Semaglutide Starting Dose: 0.25 mg weekly for 4 weeks, then increase gradually Tirzepatide Starting Dose: 2.5 mg weekly for 4 weeks, then increase gradually

What to Expect:

• Week 1-4: Side effects most common (usually mild nausea)
• Week 4-8: Appetite reduction becomes noticeable
• Week 8-12: Weight loss typically becomes visible (5-10 pounds)
• Month 3+: Continued steady weight loss (1-2 pounds per week)

Step 7: Attend Follow-Up Appointments

Regular check-ins allow your provider to:

• Monitor side effects
• Adjust dosage as needed
• Track weight loss progress
• Modify treatment plan if necessary

Most programs schedule monthly follow-ups, though some offer more frequent support.

Frequently Asked Questions

How much do GLP-1 weight loss programs cost? GLP-1 program costs range from $199/month (compounded medications through TrimRx) to $1,000+ per month (brand-name medications through programs like Ro). The total cost depends on whether you choose compounded or brand-name medications, insurance coverage, and any additional membership fees.

Do I need a prescription for GLP-1 weight loss medications? Yes, all GLP-1 medications (semaglutide and tirzepatide) require a prescription from a licensed healthcare provider. Telehealth programs connect you with licensed doctors who can evaluate your eligibility and prescribe if appropriate.

What’s the difference between Ozempic and Wegovy? Both contain the same active ingredient (semaglutide) but are FDA-approved for different uses. Ozempic is approved for type 2 diabetes, while Wegovy is specifically approved for weight loss. They differ only in available doses and packaging.

Can I use my insurance for telehealth GLP-1 programs? Some programs accept insurance (PlushCare, WeightWatchers, Form Health), while others don’t but offer more affordable compounded alternatives. Even if the program doesn’t accept insurance, you may be able to use insurance to cover the medication at a local pharmacy.

How long do I need to take GLP-1 medications? Most people take GLP-1 medications long-term to maintain weight loss. Clinical studies show that stopping the medication often leads to weight regain. Discuss with your provider about your individual treatment timeline and maintenance strategies.

Are compounded GLP-1 medications as effective as brand-name versions? Yes, compounded semaglutide and tirzepatide contain the same active ingredients at the same doses as brand-name versions. When obtained from FDA-registered compounding pharmacies, they provide equivalent therapeutic effects at significantly lower costs.

What are the most common side effects? The most common side effects are gastrointestinal: nausea, vomiting, diarrhea, constipation, and decreased appetite. These typically occur when starting the medication or increasing doses, and often improve within a few weeks. Your provider can help manage side effects.

How much weight can I expect to lose? Clinical trials show average weight loss of 15-20% of body weight over 68 weeks with semaglutide (Wegovy) and 15-22% with tirzepatide (Zepbound). Individual results vary based on starting weight, dose, adherence, and lifestyle factors.

Can I switch between different GLP-1 programs? Yes, you can switch programs, though you should coordinate with both providers to ensure continuous care and avoid gaps in medication. Some programs require commitments (like Found’s six-month minimum), so review cancellation policies before signing up.

What happens if I can’t afford to continue treatment? If cost becomes an issue, talk to your provider about options like switching to compounded medications, adjusting to a lower maintenance dose, or exploring patient assistance programs. Stopping abruptly often leads to weight regain, so work with your provider on a plan.

Key Takeaways

Choosing the Best GLP-1 Program:

• For Best Value: TrimRx offers compounded GLP-1 medications starting at $199/month with no hidden membership fees
• For Insurance Coverage: PlushCare and WeightWatchers work with major insurance providers
• For Comprehensive Support: Noom Med and Form Health include extensive lifestyle coaching
• For Women’s Health: Nurx specializes in women’s healthcare needs
• For Nutrition Focus: Hers/Hims provides dietitian-developed meal plans

Cost Considerations:

• Compounded GLP-1s cost $199-$599/month
• Brand-name GLP-1s cost $900-$1,350/month without insurance
• Watch for hidden fees like consultation costs and membership fees separate from medication
• HSA/FSA funds can be used at most providers even without insurance acceptance

Safety Standards:

• Verify providers have licensed medical professionals in your state
• Confirm compounding pharmacies are FDA-registered
• Look for accreditation from PCAB or NABP
• Ensure ongoing medical supervision and easy access to provider support

Getting Started:

• Calculate your BMI and review eligibility criteria
• Compare programs based on your priorities (cost, support, insurance)
• Complete a thorough health assessment
• Discuss realistic expectations and potential side effects with your provider

Ready to start your GLP-1 weight loss journey with transparent pricing and quality care? Visit TrimRx and get affordable access to compounded semaglutide and tirzepatide with licensed medical oversight.