Zepbound and Thyroid Issues: A Detailed Look

Introduction

Embarking on a weight loss journey, especially when navigating existing health conditions, can often feel like deciphering a complex puzzle. With the rise of innovative weight management solutions like Zepbound (tirzepatide), many individuals are discovering renewed hope for achieving their health goals. However, a crucial question often arises for those with pre-existing thyroid conditions: can you take Zepbound if you have thyroid issues? This isn’t a simple yes or no answer, but rather one that necessitates a thorough understanding of the medication, its potential effects, and the nuances of various thyroid health considerations.

In an era where personalized health is paramount, making informed decisions about your well-being requires access to clear, authoritative information. This blog post aims to shed light on the intricate relationship between Zepbound and thyroid health, providing a comprehensive overview that empowers you to have a productive discussion with your healthcare provider. We will delve into how Zepbound works, explore the specific concerns regarding thyroid conditions—from medullary thyroid carcinoma (MTC) to more common issues like hypothyroidism—and discuss the importance of rigorous medical evaluation. Our goal is to clarify the potential risks and considerations, ensuring you understand the landscape of treatment options available.

At TrimRx, our journey began with a shared vision to help individuals embrace healthier lifestyles by merging cutting-edge telehealth innovations with effective weight loss solutions. We understand that sustainable weight loss should be achieved through science, empathy, and a transparent approach. This commitment to individualized, medically supervised care underpins every aspect of our platform, which is designed to be a user-friendly and supportive space for your weight loss journey. By the end of this article, you will gain a deeper understanding of whether Zepbound might be a suitable option for you, given your unique thyroid health profile, and how a personalized program can support your path to wellness.

Understanding Zepbound: A Closer Look at How It Works

For many, the quest for effective weight loss has been a long and challenging one. Zepbound, a newer player in the pharmacotherapy landscape for weight management, offers a novel approach that has shown significant promise. To understand its compatibility with thyroid issues, it’s essential to first grasp its fundamental mechanism of action.

The Science Behind Tirzepatide

Zepbound is the brand name for tirzepatide, a groundbreaking medication that acts as a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. This dual action sets it apart from other medications that target only GLP-1 receptors. Both GIP and GLP-1 are natural incretin hormones released by the gut in response to food intake. They play crucial roles in regulating blood sugar levels and metabolism.

By mimicking the effects of these natural hormones, tirzepatide provides multiple benefits for weight management. Firstly, it enhances insulin secretion in a glucose-dependent manner, meaning it helps the body produce more insulin when blood sugar levels are high, without causing excessive insulin production when levels are normal. Secondly, it suppresses glucagon secretion, which is a hormone that raises blood sugar. Thirdly, and most relevant to weight loss, tirzepatide slows down gastric emptying. This means food stays in the stomach longer, leading to a prolonged feeling of fullness and reduced appetite. It also directly impacts brain centers involved in hunger and satiety, further contributing to a significant reduction in calorie intake. This comprehensive physiological impact is what makes Zepbound a powerful tool in the fight against obesity.

Approved Uses and Benefits

Zepbound is specifically approved by the FDA for chronic weight management in adults who are obese (with a Body Mass Index, or BMI, of 30 kg/m² or greater) or who are overweight (BMI of 27 kg/m² or greater) with at least one weight-related comorbidity, such as hypertension, dyslipidemia, type 2 diabetes, or obstructive sleep apnea (OSA). Its efficacy in reducing body weight has been demonstrated in clinical trials, showing substantial average weight loss for individuals when used in conjunction with a reduced-calorie diet and increased physical activity. For those struggling with conditions like obstructive sleep apnea, achieving significant weight loss through medications like Zepbound can lead to improved sleep quality and overall health.

Beyond numerical reductions on the scale, the benefits of Zepbound extend to various metabolic health markers. Patients often experience improvements in blood pressure, cholesterol levels, and blood sugar control, contributing to a reduced risk of cardiovascular disease and diabetes-related complications. The comprehensive impact of this medication aligns perfectly with our philosophy at TrimRx, where we believe in fostering holistic wellness. We are dedicated to providing access to clinically proven solutions like Zepbound through a personalized, medically supervised approach. This ensures that our members receive a treatment plan tailored to their unique health profile and weight loss goals, setting the foundation for lasting success. If you’re wondering whether Zepbound, or similar medications such as Ozempic®, Wegovy®, Mounjaro®, Compounded Semaglutide, Oral Semaglutide, Compounded Tirzepatide, or Oral Tirzepatide, might be right for you, we encourage you to take our free assessment quiz to determine your eligibility and explore personalized treatment options.

Zepbound and Thyroid Health: The Critical Considerations

The question, “can you take Zepbound if you have thyroid issues?” demands careful and detailed consideration, especially given the specific warnings associated with GLP-1 receptor agonists, including Zepbound. Understanding these nuances is paramount for ensuring patient safety and treatment efficacy.

The Black Box Warning: Medullary Thyroid Carcinoma (MTC)

One of the most significant concerns regarding medications like Zepbound is the “black box warning” issued by the FDA concerning medullary thyroid carcinoma (MTC). This is not a warning to be taken lightly. MTC is a rare form of thyroid cancer that originates from the C-cells (parafollicular cells) of the thyroid gland, which are responsible for producing calcitonin, a hormone that helps regulate calcium. Unlike more common types of thyroid cancer that arise from follicular cells, MTC behaves differently and often has a genetic component.

The black box warning stems from preclinical animal studies where GLP-1 receptor agonists caused an increase in thyroid C-cell tumors in rodents. While it’s crucial to understand that animal findings do not always translate directly to humans, the FDA takes such signals very seriously, especially for potentially life-threatening conditions like cancer. There is currently no definitive evidence demonstrating that these drugs cause MTC or C-cell hyperplasia (an increase in C-cells, which can be a precursor to MTC) in humans. However, out of an abundance of caution, the warning remains.

This warning dictates strict contraindications for Zepbound and similar medications. Individuals who have a personal or family history of medullary thyroid carcinoma (MTC) are advised not to use Zepbound. Furthermore, those diagnosed with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), a genetic condition that predisposes individuals to MTC, should also avoid Zepbound. These are absolute contraindications, meaning the medication should not be used under any circumstances if these conditions are present. Our commitment to safety and individualized care at TrimRx means that a thorough health screening, including a detailed medical and family history, is a fundamental part of our process. This is why we require every individual considering prescription weight loss medications to complete our free assessment quiz, enabling our affiliated medical providers to identify any such risks and ensure that any prescribed treatment plan is medically appropriate for you.

Differentiated Thyroid Cancer: A Nuanced Perspective

Beyond the distinct concern of medullary thyroid carcinoma, many individuals also wonder about the implications of Zepbound for other, more common types of thyroid cancer, collectively known as differentiated thyroid cancer. These cancers, which include papillary and follicular thyroid cancer, arise from the follicular cells that produce thyroid hormones. Papillary thyroid cancer is by far the most prevalent type of thyroid cancer, often characterized by its slow-growing and generally treatable nature.

The research surrounding GLP-1 agonists and differentiated thyroid cancer presents a more nuanced picture. Several earlier studies have shown no increased risk specifically for differentiated thyroid cancer. However, some of the most recent meta-analyses of randomized controlled trials comparing GLP-1 agonists to non-GLP-1 agonists have indicated an overall increased risk of thyroid cancer in individuals taking GLP-1s. Unfortunately, these meta-analyses often do not differentiate between MTC and differentiated thyroid cancers, making it challenging to draw definitive conclusions for the latter. A notable French study, published about a year ago, specifically suggested an increased risk in papillary thyroid cancer.

This mixed evidence leads to a critical discussion point with your healthcare provider. For individuals with a history of indolent (slow-growing) differentiated thyroid cancer, particularly small papillary thyroid cancers, some experts suggest that the metabolic health benefits of weight reduction achieved with GLP-1s like Zepbound might outweigh the potential slight increase in risk. The argument is that improving overall metabolic health, including reducing obesity and its associated risks (cardiovascular disease, diabetes, and even a decreased overall risk of other cancers), can have a more profound positive impact on long-term health than the theoretical risk to a very slow-growing, highly treatable thyroid tumor. In such cases, careful monitoring of tumor markers and imaging would be essential.

Ultimately, the decision of whether you can take Zepbound if you have a history of differentiated thyroid cancer must be made in close consultation with a qualified medical professional who can weigh your individual health profile, the specific characteristics of your thyroid condition, and the potential benefits and risks of the medication. Our personalized approach at TrimRx emphasizes this crucial dialogue. We connect you with healthcare providers who meticulously review your health information gathered from our personalized assessment to ensure that any recommendation for a prescription medication like Zepbound is based on a thorough understanding of your complete medical history and current health status.

General Hypothyroidism and Hyperthyroidism

Beyond the specific concerns of thyroid cancer, many individuals live with more common thyroid conditions, such as hypothyroidism (underactive thyroid) or hyperthyroidism (overactive thyroid). For these individuals, the question of whether Zepbound is a safe and appropriate option is equally vital.

It is important to note that the manufacturer of Zepbound, Eli Lilly, has not conducted specific studies to evaluate the safety and efficacy of tirzepatide in patients with general hypothyroidism or hyperthyroidism. This means there isn’t direct clinical trial data to provide definitive guidance on how Zepbound might specifically affect these conditions.

However, clinical trials for chronic weight management with tirzepatide did include individuals with controlled endocrine disorders. This implies that if your hypothyroidism or hyperthyroidism is well-managed and stable under current treatment (e.g., with medications like levothyroxine for hypothyroidism), you might still be considered for Zepbound, provided other contraindications are not present. Conversely, individuals whose obesity was induced by other uncontrolled endocrinologic disorders (such as Cushing Syndrome) or diagnosed monogenetic or syndromic forms of obesity (like Prader-Willi Syndrome) were typically excluded from these studies.

This distinction highlights the importance of having a thyroid condition that is stabilized and regularly monitored by a healthcare provider. An uncontrolled thyroid condition can significantly impact metabolism, energy levels, and overall health, potentially complicating the assessment of Zepbound’s effects and benefits. Therefore, if you have hypothyroidism or hyperthyroidism and are considering Zepbound, it is imperative to discuss your condition, its current management, and any related concerns thoroughly with your doctor. They will assess your overall health, including the stability of your thyroid function, to determine if Zepbound is a suitable and safe option for your personalized weight loss journey. Our comprehensive service at TrimRx ensures that these vital conversations occur, providing you with doctor consultations, necessary lab work, and unlimited support to navigate these important health decisions.

Navigating Potential Interactions and Side Effects

Any medical treatment carries potential side effects and interactions, and Zepbound is no exception. For individuals with thyroid issues or those taking thyroid medications, understanding these possibilities is critical to ensure a safe and effective weight loss journey.

Zepbound and Thyroid Medications (e.g., Levothyroxine)

For individuals managing hypothyroidism, levothyroxine is a commonly prescribed medication that replaces or supplements natural thyroid hormones. When considering Zepbound alongside levothyroxine, there are important potential interactions to be aware of:

• Impact on Blood Glucose Control: Levothyroxine, by influencing metabolism, can potentially interfere with blood glucose control. This might reduce the overall effectiveness of tirzepatide in its glucose-regulating actions, requiring closer monitoring of your blood sugar levels. Your healthcare provider may need to adjust the dosage of your diabetic medications, if applicable, during and after treatment with levothyroxine and Zepbound.
• Absorption of Oral Medications: Zepbound’s mechanism of slowing gastric emptying can affect the absorption rate of other orally administered medications. This means that the time it takes for other drugs, including oral levothyroxine, to be absorbed into your system might change. This could potentially alter their effectiveness. It’s crucial to discuss the timing of your medication doses with your healthcare provider. For levothyroxine, which is highly sensitive to absorption interference, consistent timing (typically taken on an empty stomach, separate from food, calcium, and multivitamins) is already vital. When introducing Zepbound, your doctor may recommend further spacing out the administration of levothyroxine from your Zepbound injection, or from any oral medications you take, to minimize any potential impact on its absorption.
• Monitoring and Adjustment: Given these potential interactions, your healthcare provider will emphasize the importance of close monitoring. This includes regular thyroid function tests and blood glucose checks. Any adjustments to your levothyroxine dosage or your Zepbound treatment plan will be made based on these monitoring results and your overall clinical response. At TrimRx, we prioritize transparent service, and our approach remains consistent regardless of dosage changes, ensuring you receive continuous, informed care.

Monitoring for Adverse Reactions

While serious side effects are rare, being informed and vigilant is a cornerstone of safe medication use. If you are taking Zepbound, especially with a history of thyroid issues, it’s essential to be aware of potential adverse reactions and know when to seek medical help.

• Thyroid-Specific Symptoms: As highlighted by the black box warning for MTC, pay close attention to any changes in your neck. This includes new swelling or a lump, persistent hoarseness, difficulty swallowing, or trouble breathing. Should any of these symptoms arise, contact your healthcare provider immediately.
• Other Serious Side Effects: Zepbound, like any potent medication, can have other serious side effects that require prompt medical attention. These include:
  • Pancreatitis: Severe and persistent abdominal pain, which may radiate to your back, with or without vomiting.
  • Gallbladder Problems: Pain in your upper stomach, fever, yellowing of the skin or eyes (jaundice), or clay-colored stools.
  • Kidney Damage: Symptoms such as a reduced need to urinate, swelling in your feet, ankles, or legs, weakness, or unusual tiredness. Dehydration from severe nausea, vomiting, or diarrhea can contribute to kidney problems, emphasizing the importance of staying hydrated.
  • Severe Stomach Problems: Persistent and severe nausea, vomiting, or diarrhea.
  • Low Blood Sugar (Hypoglycemia): Especially if you are also taking insulin or sulfonylureas. Symptoms include dizziness, light-headedness, sweating, confusion, headache, blurred vision, shakiness, or a fast heartbeat.
  • Vision Changes: New or worsening vision problems, particularly if you have diabetic retinopathy.
  • Depression or Thoughts of Suicide: Any new or increased feelings of anxiety, depression, or unusual changes in mood or behavior should be reported immediately.
  • Serious Allergic Reactions: Swelling of your face, lips, tongue, or throat, problems breathing or swallowing, severe rash or itching, fainting, or a very rapid heartbeat.
  • Aspiration Risk during Anesthesia: It’s crucial to inform all your healthcare providers that you are taking Zepbound before any planned surgeries or procedures requiring anesthesia or deep sedation, as Zepbound may increase the risk of food or liquid entering your lungs.

At TrimRx, our trusted and supportive approach means we ensure our members are fully informed about potential side effects and the importance of ongoing communication with their medical team. Our comprehensive service includes unlimited support, allowing you to address any concerns promptly. We work exclusively with FDA-registered and inspected pharmacies for the shipping of weight loss medications like Zepbound, ensuring you receive safe and quality pharmaceutical products, while clarifying that TrimRx partners with these pharmacies and does not provide actual medical supervision.

Who Should Not Use Zepbound: Important Contraindications

Understanding who should not take Zepbound is as crucial as knowing who can. Certain medical conditions and personal histories are absolute contraindications, meaning the medication should not be used under any circumstances due to significant health risks. This emphasis on safety is central to our values at TrimRx.

Key Contraindications for Zepbound

When considering whether you can take Zepbound if you have thyroid issues, the following specific contraindications are paramount:

• Medullary Thyroid Carcinoma (MTC) and Multiple Endocrine Neoplasia syndrome type 2 (MEN 2): As previously detailed, if you or any of your family members have ever had medullary thyroid carcinoma (MTC), or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), Zepbound is strictly contraindicated. These conditions carry a higher risk of C-cell tumors, and Zepbound’s black box warning in this area means avoiding it is a non-negotiable safety measure.
• Allergies to Tirzepatide or Ingredients: Individuals with a known hypersensitivity or severe allergic reaction to tirzepatide (the active ingredient in Zepbound) or any of the inactive ingredients in the specific product dispensed should not use the medication. Allergic reactions can be severe and life-threatening.
• History of Suicidal Thoughts or Attempts: Zepbound may cause suicidal thoughts or actions in a small number of people. Therefore, individuals with a personal history of suicidal thoughts or previous suicide attempts are advised against using Zepbound. It is vital to monitor for any new or worsening changes in mood, behavior, feelings, or thoughts while on treatment.
• Pregnancy or Planning Pregnancy: Zepbound is not recommended for use during pregnancy, as it is not known how it might affect pregnancy or harm an unborn baby. Weight loss during pregnancy, even for individuals who are overweight or obese, is generally not advised. If you are pregnant, plan to become pregnant, or become pregnant while taking Zepbound, you must inform your healthcare provider immediately.
• Severe Stomach Problems: People with severe stomach problems, including severe gastroparesis (slowed stomach emptying) or other significant issues with digesting food, should not use Zepbound. The medication’s mechanism of slowing gastric emptying could exacerbate these conditions, leading to severe discomfort and other complications.

For all these reasons, a comprehensive and honest medical evaluation is the indispensable first step in determining eligibility for any prescription weight loss medication. At TrimRx, we are committed to providing safe, effective weight loss solutions. This commitment begins with a thorough screening process. We encourage you to start your journey by taking our free assessment quiz. This personalized assessment helps our affiliated medical providers gather the crucial information needed to evaluate your health history, identify any contraindications, and determine if Zepbound or another one of our personalized weight loss programs, such as those featuring Ozempic®, Wegovy®, Mounjaro®, Compounded Semaglutide, Oral Semaglutide, Compounded Tirzepatide, or Oral Tirzepatide, is medically appropriate for you. Your safety and well-being are always our highest priority.

The TrimRx Approach: Personalized Care and Support

Navigating the complexities of weight loss, especially with existing health conditions like thyroid issues, requires more than just medication—it demands a holistic, supportive, and truly personalized approach. At TrimRx, we are dedicated to providing exactly that, merging advanced medical science with compassionate care and modern technology.

Our Commitment to Your Health Journey

Our journey at TrimRx began with a clear and profound vision: to help individuals embrace healthier lifestyles by merging cutting-edge telehealth innovations with effective, clinically proven weight loss solutions. We understand that each person’s path to wellness is unique, filled with its own challenges and triumphs. That’s why our platform is meticulously designed to be a user-friendly and supportive space where individuals receive personalized, medically supervised care. We firmly believe that sustainable weight loss should be achieved through science, empathy, and a transparent approach that puts your health goals at the forefront.

Our brand personality is built on being empathetic, innovative, trustworthy, supportive, results-oriented, and personalized. We offer compassionate care that respects every individual’s unique journey. This means combining advanced medical science, which guides our treatment protocols, with modern technology that makes access to care convenient and efficient. We are committed to transparent service, highlighting that our approach remains consistent regardless of dosage changes. Your journey with us includes comprehensive support, from initial doctor consultations and necessary lab work to ongoing unlimited support and convenient medication shipping – all with no hidden fees. Our unwavering focus on safety is paramount; we work exclusively with FDA-registered and inspected pharmacies for the shipping of weight loss medications like Zepbound, Ozempic®, Mounjaro®, and Wegovy®, as well as our compounded options such as Compounded Semaglutide, Oral Semaglutide, Compounded Tirzepatide, and Oral Tirzepatide. It is important to clarify that TrimRx partners with these pharmacies for medication fulfillment and does not provide actual medical supervision; instead, we facilitate access to licensed medical professionals who provide direct medical care.

Tailoring Your Path to Wellness

The concept of “one size fits all” simply does not apply to weight loss, particularly when medical conditions like thyroid issues are present. This is precisely why our personalized weight loss program begins with a crucial first step: our comprehensive assessment. For prescription medications like Zepbound, Ozempic®, Mounjaro®, Wegovy®, Compounded Semaglutide, Oral Semaglutide, Compounded Tirzepatide, and Oral Tirzepatide, completing our free assessment quiz is mandatory. This quiz gathers vital information about your health history, lifestyle, and specific needs, allowing our affiliated medical providers to determine your eligibility and craft a truly personalized treatment plan.

This individualized approach is crucial for addressing questions such as “can you take Zepbound if you have thyroid issues?” Our medical professionals carefully review your responses, taking into account any thyroid conditions, family medical history, and other health factors to ensure that the recommended plan is not only effective but also safe for your unique circumstances. We believe in empowering you with knowledge and support, ensuring you understand every aspect of your personalized journey.

Supporting Your Journey Beyond Prescription Medications

We recognize that the journey to wellness can also benefit from immediate support, complementing your prescribed plan or offering a starting point for those seeking general wellness support. Beyond our personalized prescription programs, we offer quick-access supplements designed to support your overall well-being during your weight loss journey.

Our GLP-1 Daily Support is crafted to assist with metabolic health, while our Weight Loss Boost offers additional aid to your weight management efforts. These supplements are available for immediate purchase, providing a convenient way to enhance your journey toward a healthier lifestyle. They are developed with the same commitment to quality and efficacy that defines all our offerings, providing an accessible option for those looking to support their wellness goals without the need for a consultation. Whether you’re exploring prescription options or seeking immediate support, TrimRx is here to guide you every step of the way, ensuring your path to a healthier life is supported by science, empathy, and personalized care.

Conclusion: Empowering Your Informed Decisions

The journey to effective weight management, especially when considering advanced treatments like Zepbound, is deeply personal and often intersects with complex medical considerations. Our exploration into the question, “can you take Zepbound if you have thyroid issues?” reveals that while Zepbound offers significant benefits for weight loss and metabolic health, its use demands careful attention to specific thyroid conditions and potential interactions. From the critical black box warning regarding medullary thyroid carcinoma to the nuanced discussions around differentiated thyroid cancer and general thyroid dysfunction, it’s clear that an individualized medical assessment is not just advisable, but absolutely essential.

Understanding the mechanism of Zepbound, its approved uses, and the array of potential side effects and interactions with other medications like levothyroxine, empowers you to engage more effectively with your healthcare provider. This knowledge forms the foundation for making informed decisions about your health and choosing a path that prioritizes both efficacy and safety.

At TrimRx, we are steadfast in our commitment to supporting you on this journey with empathy, innovation, and trust. We provide a platform where personalized, medically supervised care is accessible, designed to make sustainable weight loss attainable and tailored to your unique needs. Our comprehensive service ensures that from your initial consultation and necessary lab work to ongoing support and convenient medication delivery from FDA-registered and inspected pharmacies, your well-being is our top priority.

We encourage you to take the vital first step towards a healthier future. If you are considering prescription weight loss medications and want to understand how Zepbound or other options might fit into your health profile, especially if you have thyroid concerns, we invite you to take our comprehensive assessment. This free quiz is designed to help determine your eligibility and connect you with a personalized treatment plan developed by affiliated medical professionals. For immediate support and to complement your overall wellness during your weight loss journey, explore our quick-access supplements like GLP-1 Daily Support or Weight Loss Boost. Let TrimRx be your partner in achieving safe, effective, and sustainable weight loss, empowering you to live your healthiest life.

Frequently Asked Questions (FAQs)

1. What are the absolute contraindications for Zepbound related to thyroid health?

Zepbound carries a black box warning from the FDA for the risk of thyroid C-cell tumors. Therefore, Zepbound is absolutely contraindicated for individuals with a personal or family history of medullary thyroid carcinoma (MTC) or those with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). These conditions represent significant risks, and Zepbound should not be used in these cases.

2. If I have general hypothyroidism or hyperthyroidism, can I still consider Zepbound?

The manufacturer has not specifically studied Zepbound in patients with general hypothyroidism or hyperthyroidism. However, individuals with controlled endocrine disorders were included in clinical trials. If your hypothyroidism or hyperthyroidism is well-managed and stable under current treatment, Zepbound might be considered. A thorough evaluation by your healthcare provider, including a review of your current thyroid management and overall health, is essential to determine if Zepbound is a safe and appropriate option for you.

3. What about other types of thyroid cancer, like papillary thyroid cancer?

The evidence regarding Zepbound and differentiated thyroid cancers (like papillary thyroid cancer) is more nuanced. While some studies have shown no increased risk, recent meta-analyses indicate a potential overall increased risk of thyroid cancer with GLP-1s, though they often do not specify the type. For indolent (slow-growing) differentiated thyroid cancers, some experts suggest that the metabolic health benefits of weight reduction with Zepbound might outweigh a potential slight increase in risk, provided there is careful monitoring. This decision must be made in close consultation with your healthcare provider, considering your individual circumstances.

4. How does Zepbound interact with other thyroid medications like levothyroxine?

Zepbound can potentially interact with levothyroxine. Levothyroxine may affect blood glucose control, which could influence Zepbound’s effectiveness. Additionally, Zepbound’s mechanism of slowing gastric emptying can impact the absorption of orally administered medications, including levothyroxine. Your healthcare provider will need to closely monitor your thyroid function and blood glucose levels, and may recommend adjusting the timing of your medications to ensure optimal absorption and effectiveness of both Zepbound and levothyroxine. Always inform your doctor about all medications you are taking.