Optimizing Your Journey: Where is the Best Place to Take the Wegovy Shot?

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49 min
Published on
September 20, 2025
Updated on
September 20, 2025
Optimizing Your Journey: Where is the Best Place to Take the Wegovy Shot?

Introduction

Embarking on a weight loss journey, particularly one involving prescription medications like Wegovy®, can feel like navigating uncharted territory. Many individuals find themselves pondering the practicalities of their treatment, chief among them being the proper administration of their weekly injection. It’s a common and entirely valid question: “Where is the best place to take the Wegovy shot?” The thought of self-injecting can initially feel daunting, sparking concerns about effectiveness, comfort, and safety. Yet, understanding the nuances of injection sites and techniques is a crucial step toward a successful and comfortable experience.

This comprehensive guide is designed to demystify the process of administering Wegovy®, a powerful tool in chronic weight management. We understand that sustainable weight loss should be achieved through science, empathy, and a transparent approach. Our aim is to provide clear, actionable insights into selecting and preparing injection sites, mastering the injection technique, and understanding the vital aspects of medication storage and managing potential side effects. By the end of this post, you will gain a deeper understanding of how to confidently and effectively administer your Wegovy® dose, supported by the latest information and our dedication to your well-being. We will cover the approved injection sites, provide a step-by-step guide, offer tips for maximizing effectiveness, and discuss how TrimRx’s personalized programs can empower you on this transformative path.

Understanding Wegovy® and Its Role in Weight Management

Wegovy®, with its active ingredient semaglutide, represents a significant advancement in the medical management of chronic weight issues. Approved by the U.S. Food and Drug Administration (FDA) for adults with a body mass index (BMI) of 30 or higher (obesity) or a BMI of 27 or higher (overweight) with at least one weight-related medical condition (such as high blood pressure, high cholesterol, or Type 2 diabetes), it offers a clinically proven pathway to weight loss when combined with a reduced-calorie diet and increased physical activity. It is also approved for pediatric patients 12 years of age or older with a BMI at the 95th percentile or higher for their age and sex.

At TrimRx, our journey began with a shared vision to help individuals embrace healthier lifestyles by merging cutting-edge telehealth innovations with effective weight loss solutions. We believe that understanding how a medication works is just as important as knowing that it works. Wegovy® is a glucagon-like peptide-1 (GLP-1) receptor agonist. This means it mimics the action of a natural hormone in your body called GLP-1. This hormone plays a crucial role in regulating appetite and food intake. By activating GLP-1 receptors in the brain, Wegovy® helps to:

  • Decrease appetite: It signals to your brain that you are full, reducing hunger pangs and cravings.
  • Slow gastric emptying: Food stays in your stomach longer, promoting a feeling of fullness and potentially reducing overall food intake.
  • Improve blood sugar control: While primarily for weight management, semaglutide also helps regulate blood sugar levels, which is beneficial, especially for those with co-existing conditions like prediabetes or type 2 diabetes.

This multifaceted action contributes to significant and sustainable weight loss. Our platform is a user-friendly and supportive space where individuals receive personalized, medically supervised care—all designed to make sustainable weight loss attainable and tailored to the individual.

The Science Behind Subcutaneous Injections for Effective Absorption

Wegovy® is administered as a once-weekly subcutaneous injection, meaning it’s injected into the fatty layer just beneath the skin. This method is chosen for several strategic reasons, rooted in pharmacology and patient comfort.

Why Subcutaneous?

The subcutaneous tissue is rich in small blood vessels, which allows for the gradual and consistent absorption of the medication into the bloodstream. This slow and steady release is crucial for GLP-1 receptor agonists like semaglutide because it:

  • Maintains stable drug levels: A prolonged release ensures that the medication’s effects, such as appetite regulation, are sustained throughout the week until the next dose. This contrasts with rapid absorption, which might lead to fluctuating drug levels and a less consistent effect.
  • Reduces side effects: Gradual absorption can help minimize the intensity of certain side effects, particularly those related to the gastrointestinal system, as the body adapts to the medication over time.
  • Enhances patient convenience: Once-weekly administration greatly improves adherence, making it easier for individuals to integrate the treatment into their routines compared to daily injections.

Furthermore, subcutaneous injections are generally less painful and easier for self-administration compared to intramuscular or intravenous injections. The needle used for Wegovy® is fine and short, specifically designed to reach the subcutaneous layer without penetrating deeper tissues, which contributes to overall comfort.

Where to Take the Wegovy Shot: Approved Injection Sites

One of the most frequent questions we encounter is precisely where is the best place to take the Wegovy shot for optimal results and comfort. The good news is that there isn’t a single “best” spot that applies to everyone; rather, there are several approved and equally effective sites. According to clinical data and prescribing information, semaglutide is absorbed to a similar extent regardless of whether it’s injected in the stomach (abdomen), thigh, or upper arm. This flexibility allows for personalization based on your comfort and convenience.

The Three Approved Sites:

1. The Abdomen (Stomach)

The lower stomach area is a very common and often preferred site for subcutaneous injections due to the ample fatty tissue available.

  • Location: Inject into the soft, fatty area of your lower stomach, ensuring you stay at least 2 inches away from your belly button. This distance is important to avoid the more sensitive area around the navel and reduce the risk of hitting larger blood vessels.
  • Technique Tip: Some individuals find that standing up while injecting into the lower abdomen helps to make the skin more taut, which can ease the injection process.
  • Advantages: Typically easy to reach, often has sufficient fatty tissue.

2. The Thigh

The front of the upper thigh also offers a suitable area for injection, providing another accessible and effective option.

  • Location: Use the front upper part of your thigh. You can easily pinch a fold of skin in this area.
  • Technique Tip: If you find the skin here to be particularly soft or difficult to hold firm, choosing a slightly firmer part of the upper leg can be beneficial.
  • Advantages: Easy to access and often has a good layer of fat.

3. The Upper Arm

For those who find the other sites less convenient or prefer variety, the back of the upper arm is another viable option.

  • Location: Inject into the fatty tissue on the back or side of your upper arm.
  • Technique Tip: While it can be done independently, some people find it easier to use the upper arm with the help of a partner or by carefully maneuvering in front of a mirror.
  • Advantages: Provides an alternative if other sites are being rotated or are uncomfortable.

The Importance of Rotating Injection Sites

While all three sites are equally effective, the absolute most crucial aspect of choosing where is the best place to take the Wegovy shot is rotation. You should never inject into the exact same spot two weeks in a row.

  • Why Rotate? Consistent rotation helps prevent:
    • Skin irritation: Redness, itching, and swelling can occur if the same spot is repeatedly used.
    • Lumps or hard spots: Repeated trauma can lead to localized fat deposits or scar tissue, which can hinder proper absorption.
    • Bruising and tenderness: Giving your skin time to heal minimizes discomfort.
  • How to Rotate: You can use the same general area (e.g., your lower stomach) but vary the specific spot. For instance, inject into the right side of your lower stomach one week, then the left side the next. Or, you could rotate between the abdomen, thigh, and upper arm each week. Keeping a simple note on a calendar or on the medication box can help you remember your last injection spot.

Areas to Avoid

Regardless of your chosen site, there are specific areas where you should never inject Wegovy®:

  • Areas with scars, stretch marks, or moles.
  • Skin that is tender, hard, bruised, discolored, or red.
  • Into a muscle or vein.

At TrimRx, we believe in empowering you with comprehensive knowledge and support. Our healthcare professionals are dedicated to guiding you through selecting the ideal injection sites tailored to your body and comfort, ensuring your journey is as smooth and effective as possible. If you’re considering starting a personalized weight loss program, we encourage you to take our free assessment quiz to see if you qualify for prescription weight loss medications like Wegovy®.

Step-by-Step Guide to Administering Your Wegovy® Shot

Administering your Wegovy® injection can become a simple, routine part of your week with proper guidance. The Wegovy® pen is designed for ease of use, with a pre-set dose and a covered needle that remains hidden during the process. This meticulous approach aligns with our commitment at TrimRx to safety and effective weight loss. Our personalized programs include detailed guidance on medication administration, ensuring you feel confident and supported at every step.

Before your very first injection, it is essential to discuss the process thoroughly with your healthcare provider. Additionally, always refer to the full Instructions for Use that come with your Wegovy® pen.

Here’s a general step-by-step guide:

1. Prepare for the Injection

  • Wash Your Hands: Start by washing your hands thoroughly with soap and water to prevent infection.
  • Gather Supplies: You’ll need your Wegovy® pen, an alcohol swab, and an FDA-cleared sharps disposal container. A cotton ball or gauze pad may be useful for later.
  • Check the Pen:
    • Verify that you have the correct medication (Wegovy®) and the prescribed dose.
    • Check the expiration date on the pen and packaging. Do not use if expired.
    • Look at the medicine in the pen window. It should be clear and colorless. Small air bubbles are normal. Do not use if the liquid is cloudy, discolored, or contains particles.
    • Ensure the pen appears undamaged and has not been dropped. If you have any concerns about the authenticity or condition of your medication, contact your healthcare provider or the manufacturer directly.

2. Choose and Prepare Your Injection Site

  • Select a Site: Choose one of the approved sites: abdomen (at least 2 inches from the belly button), upper thigh, or upper arm. Remember to rotate your injection site each week.
  • Clean the Site: Clean the chosen area with an alcohol swab or soap and water. Allow the skin to dry completely before injecting. Do not touch the cleaned area until you are ready to inject.

3. Administer the Injection

  • Remove the Pen Cap: Pull the pen cap straight off the Wegovy® pen.
  • Position the Pen: Place the pen firmly and straight against your prepared injection site, ensuring you can clearly see the pen’s window.
  • Start the Injection: Push the pen firmly against your skin. You will hear a first click, indicating the injection has started, and a yellow bar will begin to move in the pen window.
  • Continue Pressure: Keep pressing the pen firmly against your skin for the entire duration of the injection. You will hear a second click—this means the injection is still ongoing. Continue to hold the pen firmly until the yellow bar completely stops moving. This typically takes about 5 to 10 seconds from the first click.
  • Confirm Completion: The injection is complete when the yellow bar stops moving. Do not remove the pen from your skin before the yellow bar stops moving.
  • Withdraw the Pen: Slowly lift the pen straight away from your skin.

4. After the Injection

  • Check the Site: If any blood appears, press lightly on the spot with a cotton ball or gauze pad. Do not rub the injection site.
  • Safe Disposal: Immediately dispose of your used Wegovy® pen in an FDA-cleared sharps disposal container. If you don’t have one, use a sturdy, leak-resistant plastic container with a tight-fitting lid (e.g., a heavy-duty plastic laundry detergent bottle). Clearly label it “Sharps Waste.” Never throw used pens into household trash. Contact your local municipality for information on proper sharps disposal in your area.

What if Medication Leaks or I Remove the Pen Too Early?

If you remove the pen from your skin too early or do not press it firmly enough for the entire injection duration, you might notice some medication leaking or squirting from the needle. In such a scenario, you may not have received your full dose. Once an injection has been started and the pen removed, you cannot restart it or give another injection to make up for the potential partial dose. For your next weekly dose, simply ensure you follow the instructions carefully, applying firm pressure until the yellow bar stops moving completely.

This level of detailed guidance is a hallmark of the care we provide at TrimRx. We understand that your weight loss journey is personal, and our supportive team is always available to answer your questions and provide reassurance. We partner with FDA-registered and inspected pharmacies for the shipping of weight loss medications, ensuring that what you receive is authentic and safe. Our commitment to transparent service means our approach remains consistent, focusing on your well-being.

Optimizing Your Wegovy® Experience: Key Considerations

Beyond mastering the injection technique, several other factors contribute significantly to the effectiveness and comfort of your Wegovy® treatment. At TrimRx, we believe in providing a holistic approach to weight loss, integrating medication with lifestyle support. Our programs are designed to support your overall wellness journey, complementing the effectiveness of medications like Wegovy®.

Consistency in Administration

  • Weekly Dose: Wegovy® is a once-weekly injection. It’s crucial to take it on the same day each week to maintain consistent medication levels in your body.
  • Time of Day: You can inject Wegovy® at any time of day, with or without food. Choose a time that best fits your schedule and helps you remember.
  • Changing Injection Day: If you need to change your injection day, you can, but ensure it has been at least two days since your last dose. For example, if you usually inject on Monday but want to switch to Friday, ensure it’s at least Wednesday before your next injection.

Proper Storage for Medication Integrity

Correct storage is vital to ensure the medication remains stable and effective.

  • Refrigeration: Store unopened Wegovy® pens in the refrigerator between 36°F and 46°F (2°C to 8°C). Keep them in the original carton to protect them from light.
  • Room Temperature Option: If needed, an unopened Wegovy® pen can be kept outside the refrigerator between 46°F and 86°F (8°C and 30°C) for up to 28 days. After 28 days, if not used, it must be discarded. Crucially, do not remove the cap during this time.
  • Do NOT Freeze: Never freeze Wegovy®. If a pen has been frozen, it must be discarded, even if it has thawed.
  • Protect from Light and Heat: Always keep the pen in its original carton to protect it from light. Discard the pen if it has been exposed to temperatures over 86°F (30°C) or left out of the refrigerator for more than 28 days.

Managing Discomfort and Injection Site Reactions

While Wegovy® uses a tiny needle, some individuals may experience minor discomfort or sensitivity.

  • Temperature: If you are sensitive to injecting cold fluid, you can take your Wegovy® pen out of the refrigerator 30-60 minutes before your injection to allow it to reach room temperature. Remember to leave the cap on during this time until you are ready to inject.
  • Injection Site Reactions: To minimize redness, swelling, itching, or bruising at the injection site, strict rotation of sites is key. Avoid injecting into areas with existing irritation or conditions. If reactions persist or are concerning, consult your healthcare provider.

What to Do If You Miss a Dose

Missing a dose can happen, but it’s important to know how to respond correctly.

  • Within 3 Days: If you miss a dose of Wegovy® and your next scheduled dose is more than two days away, take the missed dose as soon as you remember.
  • Closer to Next Dose: If it’s almost time for your next scheduled dose (less than two days away), skip the missed dose and resume your regular weekly schedule.
  • Never Double Dose: Do not take two doses at once or within a three-day period to make up for a missed dose. Consistency helps maintain stable levels for effectiveness.

Hydration and Nutrition Support

Medications like Wegovy® work best when integrated into a healthy lifestyle.

  • Hydration: Staying well-hydrated is crucial, especially when experiencing gastrointestinal side effects like nausea or diarrhea.
  • Balanced Diet: Focus on nutrient-dense, whole foods. Eating smaller, more frequent meals can also help manage appetite and potential nausea. Our quick-access supplements like GLP-1 Daily Support and Weight Loss Boost can provide additional support for your overall wellness during your weight loss journey.

We are here for you! Our brand is empathetic, innovative, trustworthy, supportive, results-oriented, and personalized. We offer compassionate care that respects every individual’s unique journey by combining advanced medical science with modern technology. For personalized guidance on how to optimize your Wegovy® experience, we invite you to take our free assessment quiz to discover the best path forward.

Navigating Potential Side Effects and When to Seek Support

While Wegovy® is an effective tool for weight management, like any medication, it can be associated with side effects. Most individuals experience mild to moderate side effects, primarily gastrointestinal, which often diminish as the body adjusts to the medication. Our empathetic care at TrimRx means we are here to support you through every aspect of your weight loss journey, including managing potential side effects.

Common Gastrointestinal Side Effects

These are the most frequently reported side effects and typically occur during the initial weeks of treatment or when the dose is increased:

  • Nausea: A feeling of sickness in the stomach.
  • Vomiting: Expelling stomach contents.
  • Diarrhea or Constipation: Changes in bowel habits.
  • Stomach Pain (Abdominal Pain): Discomfort in the belly area.
  • Heartburn/Indigestion: A burning sensation in the chest.
  • Burping: Expelling gas from the stomach through the mouth.

Tips for Managing Common GI Side Effects:

  • Eat Smaller Meals: Opt for frequent, smaller meals instead of large ones.
  • Slow Down Eating: Eat slowly and mindfully.
  • Choose Bland Foods: If experiencing nausea, try bland, low-fat foods like crackers, toast, rice, or bananas.
  • Stay Hydrated: Drink plenty of fluids, especially water or electrolyte-rich beverages, to prevent dehydration, particularly with vomiting or diarrhea.
  • Avoid Trigger Foods: Limit fatty, spicy, or very sweet foods that can worsen nausea.
  • Ginger: Some find relief from nausea with ginger (ginger tea, ginger chews).
  • Consult Your Doctor: Your healthcare provider may adjust your dosing schedule or provide anti-nausea medication if symptoms are severe or persistent. Our commitment to transparent service means we provide unlimited support, ensuring you have the resources and guidance you need.

Injection Site Reactions

As mentioned, minor reactions at the injection site are possible, including:

  • Redness
  • Swelling
  • Itching
  • Bruising
  • Tenderness

These are typically mild and transient. Consistent rotation of injection sites is the best preventive measure. If you experience persistent or concerning skin reactions, reach out to your healthcare provider.

When to Seek Medical Attention

While most side effects are manageable, some symptoms warrant immediate medical attention. It is crucial to be aware of these and contact your healthcare provider or seek emergency care if they occur:

  • Signs of a Serious Allergic Reaction: Hives, difficulty breathing or swallowing, swelling of the face, lips, tongue, or throat. These require emergency medical help.
  • Pancreatitis (Inflammation of the Pancreas): Severe, persistent stomach pain (often radiating to the back) with or without vomiting.
  • Gallbladder Problems: Upper stomach pain, fever, yellowing of the skin or eyes (jaundice), or clay-colored stools.
  • Hypoglycemia (Low Blood Sugar): Especially if you have Type 2 diabetes and are taking other medications for it. Symptoms include dizziness, lightheadedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, or hunger.
  • Kidney Problems: Decreased urination, swelling in your legs, ankles, or feet.
  • Changes in Vision: Especially if you have diabetic retinopathy.
  • Increased Heart Rate: Persistent fast heartbeat.
  • Depression or Thoughts of Suicide: Any new or worsening mood changes, or suicidal thoughts.

Regular follow-up appointments with your healthcare provider are essential for monitoring your progress and addressing any concerns. At TrimRx, we combine advanced medical science with modern technology to deliver compassionate, results-oriented care. We encourage you to take our free assessment quiz to begin your journey with personalized, medically supervised support.

The TrimRx Difference: Personalized Support for Your Weight Loss Journey

At TrimRx, we understand that a successful weight loss journey extends far beyond just medication. It’s about comprehensive support, personalized care, and a trusted partnership every step of the way. Our journey began with a shared vision to help individuals embrace healthier lifestyles by merging cutting-edge telehealth innovations with effective weight loss solutions. We believe that sustainable weight loss should be achieved through science, empathy, and a transparent approach, placing your health and well-being at the forefront.

Our Core Values and Approach

Our brand personality is built on being empathetic, innovative, trustworthy, supportive, results-oriented, and personalized. We are committed to providing compassionate care that respects every individual’s unique journey. When you choose TrimRx, you’re not just getting a prescription; you’re gaining a dedicated team and a structured program designed for your success.

Our comprehensive service includes:

  • Doctor Consultations: Receive a thorough medical evaluation by licensed healthcare professionals to determine your eligibility and create a personalized treatment plan.
  • Medication: Access to clinically proven weight loss medications, including branded options like Wegovy®, Ozempic®, Mounjaro®, Zepbound®, and compounded alternatives such as Compounded Semaglutide, Oral Semaglutide, Compounded Tirzepatide, and Oral Tirzepatide. We work exclusively with FDA-registered and inspected pharmacies for the shipping of these medications, ensuring quality and safety. It’s important to remember that while branded medications like Wegovy® are FDA-approved, compounded medications are not FDA-approved, though they are sourced from FDA-registered and inspected pharmacies.
  • Lab Work: Necessary lab tests are integrated into your program to monitor your health and ensure the safety and effectiveness of your treatment.
  • Unlimited Support: Our commitment to transparent service includes ongoing, unlimited support from our team. Whether you have questions about your medication, side effects, or lifestyle adjustments, we are here to provide guidance and encouragement.
  • Shipping: Your medication is conveniently shipped directly to your door, with no hidden fees.

Our Product Offerings: Tailored to Your Needs

We provide options to suit different stages and preferences in your weight loss journey:

Personalized Weight Loss Program (Requires Quiz)

For those seeking prescription weight loss medications, our personalized program starts with a free assessment quiz. This quiz helps us understand your health profile and determine your eligibility for medications such as:

  • Compounded Semaglutide
  • Oral Semaglutide
  • Ozempic®
  • Compounded Tirzepatide
  • Oral Tirzepatide
  • Mounjaro®
  • Zepbound®
  • Wegovy®

Taking our free assessment quiz is the first step towards a tailored plan that integrates the most suitable medication with ongoing support, ensuring you have the resources needed for lasting results.

Quick-Access Supplements (No Quiz Required)

In addition to our prescription programs, we offer quick-access supplements designed to support overall wellness and enhance your weight loss efforts, available for immediate purchase:

  • GLP-1 Daily Support: Formulated to support the body’s natural processes, complementing your weight management strategy.
  • Weight Loss Boost: Designed to provide additional support for your metabolism and energy levels.

At TrimRx, we are dedicated to safe, effective weight loss and individualized care. Our platform offers a seamless and supportive experience, making your path to a healthier lifestyle achievable and sustainable.

Conclusion

Understanding where is the best place to take the Wegovy shot and how to administer it correctly is a foundational element of a successful weight loss journey with this medication. We’ve explored the approved injection sites—the abdomen, thigh, and upper arm—emphasizing that while all are equally effective, the crucial element is consistent rotation to ensure comfort and optimal absorption. We’ve also detailed the step-by-step injection process, provided essential tips for managing your medication schedule, ensuring proper storage, and navigating potential side effects.

Your journey toward a healthier weight is personal, and at TrimRx, we are committed to being your trusted partner. We merge cutting-edge telehealth with compassionate, medically supervised care, ensuring you have access to personalized solutions and unwavering support. Our comprehensive programs, which include doctor consultations, medication sourced from FDA-registered and inspected pharmacies, lab work, unlimited support, and convenient shipping, are designed to make sustainable weight loss not just a goal, but an attainable reality.

We believe in empowering you with knowledge and support, allowing you to focus on your progress with confidence. If you’re ready to explore a personalized weight loss solution, we encourage you to take our free assessment quiz to see if you qualify for prescription weight loss medications like Wegovy®. For immediate support for your overall wellness, consider our quick-access supplements like GLP-1 Daily Support and Weight Loss Boost. Let us help you embrace a healthier, more vibrant life.

Frequently Asked Questions (FAQ)

Q1: Is there truly no single “best” place to take the Wegovy shot for everyone?

A1: That’s right. For Wegovy® (semaglutide), the FDA-approved injection sites are the abdomen (stomach), thigh, and upper arm. Clinical studies have shown that the medication is absorbed to a similar extent regardless of which of these three sites is used. The “best” place ultimately comes down to individual comfort, convenience, and the crucial practice of rotating injection sites to prevent irritation and ensure consistent absorption over time. Our healthcare professionals at TrimRx can help guide you in choosing the sites that work best for your body and lifestyle.

Q2: How often should I rotate my injection sites, and what happens if I don’t?

A2: You should rotate your injection site with every single weekly injection. This means not using the exact same spot two weeks in a row. For example, if you injected into your left thigh this week, you might choose your right thigh or a different area of your left thigh next week. If you consistently inject into the same spot, you risk developing skin irritation, bruising, tenderness, or even localized fat deposits or scar tissue. These issues can make future injections uncomfortable and potentially interfere with the proper absorption of the medication.

Q3: What should I do if I experience nausea or other gastrointestinal side effects with Wegovy®?

A3: Nausea, vomiting, diarrhea, or constipation are common gastrointestinal side effects, especially when first starting Wegovy® or after a dose increase. To help manage these, try eating smaller, more frequent meals, avoiding fatty or spicy foods, staying well-hydrated, and eating slowly. Bland foods like toast, rice, or bananas can also be helpful. If side effects persist, worsen, or become severe, it’s important to contact your healthcare provider. Our TrimRx programs include unlimited support, where our team can provide guidance on managing these symptoms effectively.

Q4: How does TrimRx ensure the authenticity and safety of the Wegovy® medication provided?

A4: At TrimRx, we prioritize your safety and the effectiveness of your treatment. We partner exclusively with FDA-registered and inspected pharmacies for the shipping of all our weight loss medications, including branded options like Wegovy®. This partnership ensures that the medication you receive meets rigorous quality and safety standards. While Wegovy® itself is FDA-approved, we are committed to transparency and clarity, noting that any compounded medications we offer are sourced from these same high-standard pharmacies but are not FDA-approved. Our comprehensive service ensures you receive authentic medication as part of your personalized, medically supervised weight loss program.

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