Does It Matter What Time of Day You Take Ozempic? Optimizing Your Weekly Dose

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49 min
Published on
September 21, 2025
Updated on
September 21, 2025
Does It Matter What Time of Day You Take Ozempic? Optimizing Your Weekly Dose

Introduction

Many individuals embarking on a weight loss journey, or managing type 2 diabetes, often face numerous questions about their medications. One common query that surfaces when considering or starting a GLP-1 medication like Ozempic® is: does the specific time of day you administer your dose truly make a difference? Ozempic®, a branded form of semaglutide, has emerged as a significant tool in managing type 2 diabetes and supporting weight loss for many, thanks to its once-weekly dosing schedule. Its active ingredient works by mimicking natural hormones to regulate blood sugar and influence appetite. However, the precise timing of this weekly injection can sometimes feel like a puzzle.

This comprehensive guide aims to demystify the nuances of Ozempic® dosing, particularly addressing the flexibility surrounding the time of day for injection. We will delve into the science behind Ozempic®’s long-acting nature, explore how personalized timing can enhance your experience, and provide practical strategies for integrating this medication seamlessly into your lifestyle. If you’ve ever found yourself wondering whether a morning shot versus an evening injection could impact your results or side effects, you’re not alone. While the core efficacy of Ozempic® remains consistent regardless of the hour, understanding the subtle ways you can optimize your personal experience, particularly concerning side effect management, is key. We offer insights not just on the ‘what’ but the ‘how’ – how to make this powerful medication work best for you, underpinned by our commitment to science, empathy, and transparent care at TrimRx. Ultimately, while the exact time of day you take Ozempic® doesn’t dictate its overall effectiveness, strategically choosing your injection time can significantly enhance comfort and adherence, which are crucial for achieving sustainable results within a medically supervised weight loss program. This post will guide you through the medication’s mechanism, the importance of consistent weekly dosing, practical tips for timing your injection, and how our comprehensive approach at TrimRx can support your journey.

The Science Behind Ozempic®: How It Works for Your Body

To understand why the time of day you take Ozempic® is less critical than the day of the week, it’s essential to grasp how this medication works within your body. Ozempic® contains semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist. This class of medication mimics the action of a natural hormone called GLP-1, which plays a crucial role in regulating blood sugar and appetite.

When you administer Ozempic®, semaglutide starts working in several key ways:

  • Stimulating Insulin Release: It encourages your pancreas to release insulin when blood sugar levels are high. This helps to lower glucose levels effectively.
  • Suppressing Glucagon Secretion: It reduces the amount of glucagon, another hormone that raises blood sugar, produced by the pancreas.
  • Slowing Gastric Emptying: Semaglutide slows down the rate at which food leaves your stomach. This leads to a feeling of fullness, which can help reduce overall food intake.
  • Targeting Appetite Centers in the Brain: It influences brain areas involved in appetite regulation, leading to reduced hunger and cravings.

Ozempic® is FDA-approved for managing type 2 diabetes, reducing the risk of major cardiovascular events in adults with type 2 diabetes and established cardiovascular disease, and for certain kidney conditions. Its mechanism of action makes it a valuable tool not only for glycemic control but also for supporting weight loss. Other similar medications like Wegovy® are also FDA-approved specifically for chronic weight management, while Zepbound® and Mounjaro® contain tirzepatide, another powerful GLP-1 (and GIP) receptor agonist also FDA-approved for weight management or type 2 diabetes, respectively.

Understanding these actions underscores why consistent, weekly administration is far more important than the specific hour of the day. The effects of semaglutide are sustained over an extended period, meaning your body benefits from its presence throughout the entire week, not just for a few hours after injection.

The Importance of Consistency: Why Weekly Matters

At TrimRx, our journey began with a shared vision to help individuals embrace healthier lifestyles by merging cutting-edge telehealth innovations with effective weight loss solutions. A cornerstone of this vision is our emphasis on consistency and adherence to prescribed treatment plans. For medications like Ozempic®, its once-weekly dosing schedule is fundamental to its effectiveness and the sustainable results our programs aim to achieve.

Maintaining a Steady State

Ozempic® is designed to be a long-acting medication. This means that once injected, its active compound, semaglutide, remains in your system for approximately seven days, steadily working to regulate your body’s metabolic processes. This extended duration of action is critical. Unlike daily medications that require precise timing around meals, Ozempic® works to establish a “steady state” in your body. This refers to the point where the amount of medication entering your body equals the amount being eliminated, resulting in consistent therapeutic levels.

This steady state helps in:

  • Consistent Blood Sugar Control: For individuals managing type 2 diabetes, a steady medication level ensures continuous support in regulating glucose levels throughout the week, minimizing fluctuations.
  • Sustained Appetite Regulation: For those utilizing Ozempic® for weight management support, the continuous presence of semaglutide helps reduce appetite and hunger consistently, contributing to a lower overall calorie intake and supporting lifestyle changes.
  • Predictable Side Effect Profile: As your body adjusts to the medication, maintaining a steady level can help minimize the “peaks and valleys” of medication effects, often leading to a reduction in initial side effects over time.

Because Ozempic® functions by maintaining these stable levels, the specific time of day you take it on your chosen weekly injection day has minimal impact on its overall efficacy. The most vital aspect is ensuring that you administer your dose reliably on the same day each week. This consistency is what allows the medication to build and maintain its therapeutic effect.

Dosing Schedule and Gradual Escalation

Our personalized weight loss programs, which may include options like Ozempic®, follow a carefully structured dosing schedule. This typically involves starting with a lower dose and gradually increasing it over several weeks. This titration process is designed to help your body slowly adjust to the medication, thereby minimizing potential gastrointestinal side effects such as nausea, vomiting, stomach pain, constipation, or diarrhea.

A typical Ozempic® dosing schedule looks like this:

  • Starting Dose: 0.25 mg once a week for the first four weeks. This initial dose is primarily for acclimation, helping your system get used to the medication.
  • First Increase: After four weeks, the dose is usually increased to 0.5 mg once a week. At this point, you should begin to see more pronounced effects on blood sugar control and appetite.
  • Maintenance Dose: Depending on your individual response and tolerability, your healthcare provider may further increase the dose to 1 mg or, if needed, up to a maximum of 2 mg once a week.

This gradual escalation is a key component of our empathetic and results-oriented approach at TrimRx. It allows your body the necessary time to adapt, making your weight loss journey as comfortable and effective as possible. During this entire process, consistency in your weekly injection day is paramount, ensuring that each dose builds upon the last to achieve the desired therapeutic benefits safely and effectively. To explore if a personalized program, including medications like Ozempic®, could be right for you, we encourage you to take our free assessment quiz.

Does It Matter What Time of Day You Take Ozempic? Unpacking the Flexibility

The question of “does it matter what time of day you take Ozempic” is one we hear frequently, and it speaks to the desire for optimal results and comfort. At TrimRx, we believe in transparent service and empowering you with accurate, science-backed information. The definitive answer is that the specific time of day you administer your weekly Ozempic® dose does not impact its overall effectiveness. However, choosing a time that aligns with your personal routine and helps manage potential side effects can significantly enhance your experience and adherence.

The ‘When’ vs. The ‘How Often’: Understanding the Core Principle

Ozempic® is a long-acting medication with a half-life of approximately seven days. This means that once injected, the semaglutide works continuously in your system throughout the week. Its therapeutic effects—like blood sugar regulation and appetite suppression—are sustained over this entire period, rather than being concentrated immediately after injection.

Therefore, the critical factor is consistency in the day of the week, not the specific hour. Whether you inject at 7 AM on a Monday or 9 PM on a Monday, the medication will be active in your system for the following seven days. This flexibility is one of the advantages of a once-weekly medication, allowing for greater convenience and easier integration into diverse lifestyles. Our goal at TrimRx is to support your individual journey, and this includes helping you find a dosing routine that works seamlessly for you.

Personalizing Your Injection Time: Managing Potential Side Effects

While the time of day doesn’t affect efficacy, it can be a strategic choice for managing potential side effects, particularly during the initial weeks of treatment when your body is adjusting. The most common side effects are gastrointestinal, such as nausea, vomiting, and stomach discomfort.

Morning Injections: Pros and Considerations

Many individuals opt for morning injections, often finding it easier to incorporate into a fixed daily routine.

  • Convenience and Memory: For those with busy schedules, taking the injection first thing in the morning ensures it’s done and not forgotten later in the day. It can be paired with a morning habit, like having breakfast or getting ready for work.
  • Daytime Awareness: Some prefer to be awake and alert if they experience any immediate, though rare, reactions.
  • Food Choices: If you take your injection in the morning, you might consciously choose lighter, less greasy foods for breakfast to minimize the potential for nausea. Our expert insights at TrimRx often guide individuals on dietary adjustments that can complement their medication and enhance comfort.

One consideration for morning injections is if nausea tends to be a significant initial side effect. Experiencing nausea throughout the day might be disruptive for some. However, most side effects tend to diminish as your body becomes accustomed to the medication.

Evening Injections: Embracing Overnight Relief

Conversely, taking Ozempic® in the evening, often before bed, is a popular strategy for proactively managing potential side effects.

  • Sleeping Through Discomfort: If you experience initial nausea or stomach discomfort, taking the injection at night allows you to potentially sleep through the peak of these sensations, waking up feeling better.
  • Reduced Daytime Disruption: This can be particularly beneficial for those with demanding jobs or social commitments, minimizing any potential interference from side effects during their waking hours.
  • Injection Site Sensitivity: If you experience any mild injection site pain or discomfort, an evening dose might mean this sensation subsides overnight, preventing it from disrupting your daytime activities.

As your body reaches a steady state, typically after several weeks on a consistent dose, the intensity of side effects usually lessens, regardless of when you take your injection. Our compassionate care recognizes that every individual’s journey is unique, and we support you in finding the timing that offers the most comfort and confidence.

Ozempic® and Meal Timing: A Non-Factor for Efficacy

Another common question revolves around whether Ozempic® should be taken with or without food, or at a specific time relative to meals. Given its long half-life and sustained action, Ozempic® can be administered with or without food. Your meal timing does not affect how the medication works because its impact is spread across the entire week, not concentrated around a specific meal.

This stands in contrast to some other diabetes medications, like certain insulins or oral hypoglycemics, which require careful timing relative to food intake. The flexibility of Ozempic® in this regard further simplifies its integration into your routine, aligning with our belief at TrimRx that sustainable weight loss should be attainable and tailored to the individual, fitting seamlessly into your life rather than dictating it.

Crafting Your Ozempic® Routine with TrimRx

At TrimRx, we understand that weight loss is a personal and often challenging journey. That’s why our platform is designed to be a user-friendly and supportive space where individuals receive personalized, medically supervised care. When you partner with us for your weight loss goals, our approach goes far beyond simply prescribing medication; it’s about empowering you with a comprehensive service that includes all the necessary components for safe and effective results.

Beyond the Injection: Our Holistic Approach to Weight Loss

We believe that sustainable weight loss should be achieved through science, empathy, and a transparent approach. Our comprehensive service is built on several pillars:

  • Doctor Consultations: Every individual engaging in our personalized weight loss program begins with a thorough consultation with a licensed healthcare provider. This ensures a deep understanding of your health history, current challenges, and weight loss goals, leading to a truly personalized treatment plan.
  • Medication Management: For eligible individuals, prescription weight loss medications like Ozemp®, Zepbound®, Wegovy®, Mounjaro®, Compounded Semaglutide, Compounded Tirzepatide, Oral Semaglutide, or Oral Tirzepatide may be part of your plan. Our providers carefully assess your eligibility to ensure the safest and most effective medication choice for you.
  • Lab Work: To provide the most accurate and safe medical supervision, we often incorporate lab work to gain a complete picture of your health, monitor your progress, and make informed adjustments to your treatment plan as needed.
  • Unlimited Support: Your journey is not a solitary one. We provide unlimited support to answer your questions, address concerns, and guide you through every stage. This unwavering support is a testament to our empathetic and supportive brand personality.
  • Convenient Shipping: Medications are shipped directly to your door, making the process as convenient as possible. We focus on delivering a seamless experience, allowing you to focus on your health.

This integrated approach ensures that you receive compassionate care that respects your unique journey, combining advanced medical science with modern technology for results-oriented solutions. To begin your journey and see if you qualify for our personalized prescription weight loss medications, we invite you to take our free assessment quiz.

Personalized Support Every Step of the Way

The flexibility of Ozempic® dosing highlights our commitment to personalization. While the time of day may be flexible, our support is constant. Our healthcare providers work with you to determine the best day of the week for your injection and discuss strategies for timing your dose to best manage potential side effects and fit your lifestyle. This individualized care extends to all aspects of your treatment, ensuring that your plan evolves with your needs and responses.

We emphasize that our approach remains consistent regardless of dosage changes. As you titrate your medication, the comprehensive service—including ongoing consultations, support, and medication delivery—continues seamlessly, reflecting our dedication to transparent and consistent care.

Ensuring Safety and Quality: Our Pharmacy Partnerships

Safety is paramount at TrimRx. We understand the importance of trust, especially when it comes to medications. That’s why we work exclusively with FDA-registered and inspected pharmacies for the shipping of all weight loss medications. For FDA-approved branded medications such as Ozempic®, Wegovy®, Zepbound®, and Mounjaro®, we ensure that these are sourced and dispensed responsibly. For our compounded medications, it is important to note that while the pharmacies we partner with are FDA-registered and inspected, compounded medications themselves are not FDA-approved. This distinction is crucial for transparency and your peace of mind. Our rigorous selection of pharmacy partners underscores our commitment to providing safe, high-quality solutions throughout your weight loss journey.

Practical Tips for Consistent Ozempic® Administration

Establishing a consistent routine for your weekly Ozempic® injection is crucial for maximizing its benefits and ensuring a smooth weight loss journey. While the exact time of day you take Ozempic doesn’t affect its efficacy, how you integrate it into your life can greatly impact your adherence and overall experience. Here are some practical strategies recommended by health professionals and aligned with the supportive ethos of TrimRx:

Strategic Day Selection: When to Administer Your Dose

Choosing the right day of the week for your injection can be just as important as choosing a convenient time.

  • Consider Your Schedule: Select a day that is generally less busy or more predictable for you. For many, this might be a weekend day, like Saturday or Sunday.
  • Plan for Initial Side Effects: Especially during the first few weeks when your body is adjusting to a new dose, you might experience mild side effects. Choosing a day when you have fewer obligations can allow you to rest and manage any discomfort at home, should it arise. For example, some prefer Sunday evenings so any potential nausea peaks overnight before the work week begins.
  • Consistency is Key: Once you pick a day, stick with it. This establishes a predictable rhythm, making it easier to remember your weekly dose. If you’re wondering which day to choose, our healthcare providers within the TrimRx program can offer personalized guidance during your consultation.

Pairing with Routine: Building a Weekly Habit

Integrating your Ozempic® injection into an existing weekly habit can significantly improve adherence.

  • Link to a Regular Event: Think about something you do consistently once a week. This could be grocery shopping, doing laundry, attending a specific class, or a weekly meal prep session. Administer your injection immediately before or after this activity.
  • Set Digital Reminders: Utilize your smartphone or smart device to set a recurring weekly reminder. Label it clearly, perhaps as “Ozempic Time” or “Weekly Wellness Check-in,” to make it unmistakable. Our patient-focused approach at TrimRx emphasizes providing you with tools and strategies to make adherence simple and stress-free.
  • Visual Cues: You might keep your Ozempic® pen in a consistent, easily visible, yet safe and appropriate storage location (more on this below) in your refrigerator as a visual cue on your injection day.

Proper Storage and Handling: Keeping Your Medication Effective

Correct storage and handling of your Ozempic® pen are vital for its safety and effectiveness.

  • Unused Pens: New, unopened Ozempic® pens must be stored in the refrigerator between 36°F and 46°F (2°C and 8°C).
  • In-Use Pens: Once you start using a pen, you have more flexibility. It can be stored either in the refrigerator or at room temperature (between 59°F and 86°F / 15°C and 30°C) for up to 56 days (8 weeks).
  • Expiration and Disposal: Always check the expiration date on the label. An in-use pen should be discarded after 8 weeks, even if there is still medication left. Never freeze Ozempic®, and do not use it if it has been frozen.
  • Protection: Keep your Ozempic® pen protected from heat and direct light. Always store it with the pen cap on to shield it from light.
  • Safe Disposal: Used needles and empty pens should be disposed of in an FDA-approved sharps container or a strong, plastic household container immediately after use. Never reuse needles, and never share your Ozempic® pen with anyone else, even if the needle is changed, due to the serious risk of infection.

Our commitment to safety extends to ensuring you have all the necessary information for the proper handling of your medication, supporting your well-being throughout your personalized weight loss program.

Injection Site Rotation: Maximizing Comfort and Absorption

Ozempic® is injected subcutaneously (under the skin) using a fine needle. While the injection technique is generally straightforward, rotating your injection sites is important for comfort and to prevent irritation.

  • Recommended Sites: The best injection sites are the abdomen, thigh, and upper arm. These areas have sufficient fatty tissue for proper absorption.
  • Rotation Strategy: Do not inject into the exact same spot each week. Instead, alternate between these three general areas, and within each area, choose a slightly different spot for each injection. For example, if you inject in your abdomen one week, try your thigh the next, and your arm the week after. If you prefer to stick to one area, like your abdomen, ensure you choose a different spot within that area each time.
  • Avoid Problem Areas: Do not inject into moles, scars, stretch marks, or areas with broken, bruised, red, or hard skin.
  • Optimal Absorption: While all recommended sites offer effective absorption, the abdomen often provides slightly faster absorption due to its rich blood supply. However, the difference is typically not significant enough to impact the overall weekly efficacy, as the medication is long-acting.

By following these practical tips, you can ensure consistent, safe, and comfortable administration of your Ozempic® medication, helping you stay on track with your personalized weight loss journey.

What if You Miss a Dose? A Guide to Staying on Track

Even with the best intentions and carefully crafted routines, sometimes a dose of medication can be missed. At TrimRx, we understand that life happens, and our supportive approach means guiding you through these moments without derailing your progress. If you miss a dose of Ozempic®, here’s what you should do:

  • Act Quickly if Within 5 Days: If you remember your missed dose within five days (120 hours) of your regularly scheduled injection day, you should administer it as soon as possible. After taking the missed dose, simply resume your regular once-weekly schedule. For example, if your usual injection day is Sunday and you remember on Thursday (within 5 days), take your dose then, and your next dose would still be the following Sunday.
  • If More Than 5 Days Have Passed, Skip It: If more than five days (120 hours) have passed since your missed dose, it’s best to skip that dose entirely. Do not take two doses to make up for the missed one. Instead, simply wait for your next regularly scheduled injection day and continue with your usual weekly schedule. Taking a dose too close to your next scheduled injection could lead to an increased risk of side effects.

It is rare for individuals to forget their weekly Ozempic® dose, partly because the benefits are often quite motivating. However, having a clear plan for missed doses is part of our comprehensive care, ensuring you feel supported and informed at every turn. Consistency is paramount for the medication’s effectiveness, but minor deviations can be managed by following these guidelines. If you have any concerns or questions about a missed dose, our team is always available to provide expert guidance as part of your unlimited support.

Beyond Ozempic®: Exploring Your Personalized Weight Loss Journey with TrimRx

At TrimRx, our commitment extends to offering a spectrum of clinically proven solutions tailored to your unique health profile and weight loss aspirations. While Ozempic® is a powerful tool for many, we recognize that individual needs vary. Our innovative, trustworthy, and results-oriented approach means providing diverse options, all under medically supervised care.

Discovering Your Path: The TrimRx Assessment Quiz

For individuals seeking a personalized, medically supervised weight loss program that may include prescription medications, the first step is our comprehensive, free assessment quiz. This intelligent questionnaire helps us understand your health history, lifestyle, and goals to determine your eligibility for our advanced treatment plans.
Upon completing the quiz, if you qualify, our healthcare providers will develop a customized treatment plan that could include a range of effective medications, such as:

  • Compounded Semaglutide: A highly effective GLP-1 receptor agonist, similar to the active ingredient in Ozempic® and Wegovy®.
  • Oral Semaglutide: An alternative oral formulation for those who prefer not to inject.
  • Ozempic®: The FDA-approved branded semaglutide injection for type 2 diabetes and certain cardiovascular risk reductions.
  • Compounded Tirzepatide: A dual GIP and GLP-1 receptor agonist, similar to the active ingredient in Mounjaro® and Zepbound®.
  • Oral Tirzepatide: An innovative oral option for this powerful dual agonist.
  • Mounjaro®: The FDA-approved branded tirzepatide injection for type 2 diabetes.
  • Zepbound®: The FDA-approved branded tirzepatide injection specifically for chronic weight management.
  • Wegovy®: The FDA-approved branded semaglutide injection specifically for chronic weight management.

Our meticulous process ensures that any prescription medication recommended is suitable for you, integrating seamlessly into your personalized plan. This is part of our commitment to individualized care, ensuring you receive the safest and most effective solution. Begin your personalized journey and take our free assessment quiz today.

Immediate Support for Your Wellness: TrimRx Quick-Access Supplements

We also understand that sometimes you need immediate support to complement your weight loss journey or bolster your overall wellness. For those who may not yet be ready for a prescription program, or who wish to enhance their current regimen, we offer quick-access supplements that do not require a quiz or prescription. These are readily available to support your health goals:

  • GLP-1 Daily Support: This supplement is formulated to provide daily assistance for metabolic health. It is designed to work synergistically with your body’s natural processes, supporting balanced glucose levels and promoting satiety. It’s a fantastic option for anyone looking for daily metabolic wellness support. Explore its benefits and purchase GLP-1 Daily Support here.
  • Weight Loss Boost: Engineered to provide an extra edge in your weight management efforts, our Weight Loss Boost supplement is crafted to support healthy metabolism and energy levels. It can be a valuable addition to your routine as you strive towards your goals. Discover how it can enhance your journey and purchase Weight Loss Boost here.

These quick-access supplements reflect our belief in offering comprehensive tools that cater to different stages and aspects of your wellness journey. Whether you’re considering a prescription program or seeking immediate, over-the-counter support, TrimRx is here to empower you with choices that align with your health objectives.

Conclusion: Your Partner in Sustainable Wellness

Navigating the nuances of medication, especially for something as impactful as weight management or diabetes control, can feel overwhelming. However, understanding that for Ozempic®, the core principle is consistent weekly administration, rather than a specific time of day, offers a liberating flexibility. This knowledge empowers you to tailor your injection schedule to best suit your lifestyle and manage any potential initial side effects, ultimately fostering greater adherence and more sustainable results.

At TrimRx, our commitment is to be your trusted partner on this transformative path. We merge innovative telehealth solutions with empathetic, medically supervised care, ensuring your weight loss journey is safe, effective, and profoundly personalized. From guiding you through the optimal timing for your Ozempic® dose to providing comprehensive support that includes doctor consultations, lab work, and unlimited assistance, we are dedicated to your success. Our partnerships with FDA-registered and inspected pharmacies underscore our unwavering focus on safety and quality, providing you with peace of mind.

Whether you’re exploring the potential of prescription medications like Ozempic®, Wegovy®, Zepbound®, or our compounded options through our free assessment quiz, or seeking immediate support with our GLP-1 Daily Support and Weight Loss Boost supplements, TrimRx is here to provide the science-backed solutions and compassionate care you deserve. We invite you to embrace a healthier lifestyle, supported by a team that believes in transparency, innovation, and your unique journey toward lasting well-being.

Frequently Asked Questions (FAQ)

1. Does the time of day I take Ozempic® affect how well it works?

No, the specific time of day you take Ozempic® does not affect its overall effectiveness. Ozempic® is a long-acting medication designed to work continuously in your system for about seven days. The most crucial factor is taking it once a week on the same day each week to maintain consistent levels of the medication in your body.

2. Can choosing a specific time of day help with Ozempic® side effects?

Yes, strategically choosing your injection time can help manage potential side effects, particularly during the initial weeks. For instance, some individuals prefer an evening injection to potentially sleep through any initial nausea or discomfort. Others find a morning injection fits better into their routine and allows them to adjust their food choices throughout the day if they experience mild side effects. Our TrimRx healthcare providers can help you determine the best approach for your individual needs.

3. What should I do if I miss my weekly Ozempic® dose?

If you remember your missed dose within five days (120 hours) of your regularly scheduled injection day, you should administer it as soon as possible. Then, simply resume your regular once-weekly schedule. However, if more than five days have passed, skip the missed dose and wait for your next regularly scheduled injection day. Do not take two doses to catch up.

4. Can Ozempic® be taken with food, and do I need to time it around meals?

Ozempic® can be taken with or without food. Its long-acting nature means that your meal timing does not affect how the medication works. The effects are sustained throughout the entire week, so there’s no need to time your injection specifically before or after a meal, offering greater flexibility and convenience.

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