Navigating Weight Loss and Gut Health: Can You Take Ozempic If You Have IBS?

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48 min
Published on
September 21, 2025
Updated on
September 21, 2025
Navigating Weight Loss and Gut Health: Can You Take Ozempic If You Have IBS?

Introduction

Experiencing persistent digestive discomfort—be it unpredictable abdominal pain, recurrent bloating, or unsettling changes in bowel habits—can profoundly impact daily life. For millions, these symptoms are a constant challenge, often signaling the presence of Irritable Bowel Syndrome (IBS). Meanwhile, in the pursuit of healthier lifestyles, a new class of medications, known as GLP-1 receptor agonists, has emerged as a significant tool for weight management, with some being approved for weight loss and others primarily for type 2 diabetes but increasingly used to support weight reduction. This dual focus often leads to a crucial question: can you take Ozempic if you have IBS?

At TrimRx, our journey began with a shared vision: to help individuals embrace healthier lifestyles by merging cutting-edge telehealth innovations with effective, science-backed weight loss solutions. We understand that wellness is a deeply personal journey, and for those managing conditions like IBS, the path to sustainable weight loss can seem even more complex. Our platform is designed as a user-friendly and supportive space where individuals receive personalized, medically supervised care, all designed to make sustainable weight loss attainable and tailored to the individual’s unique health profile.

This comprehensive guide will delve into the intricate relationship between GLP-1 receptor agonists, such as Ozempic®, and IBS. We’ll explore what IBS entails, how these innovative medications work, and the critical considerations for individuals living with this gastrointestinal condition. Our aim is to provide clarity, foster informed decision-making, and highlight how a personalized, empathetic, and science-driven approach, like the one we champion at TrimRx, can support your overall health and weight loss aspirations. By understanding the nuances, you’ll be better equipped to discuss your options with healthcare professionals and embark on a path that respects your body’s unique needs.

Understanding Irritable Bowel Syndrome (IBS): The Daily Challenge

Irritable Bowel Syndrome, commonly known as IBS, is a chronic gastrointestinal disorder that affects a significant portion of the adult population. It’s not a disease in the conventional sense, but rather a functional disorder, meaning there’s a problem with how the brain and gut work together, leading to symptoms without any visible damage or structural abnormalities in the digestive tract. This can make IBS particularly frustrating for those who experience it, as the discomfort is very real, yet often goes unaddressed or misunderstood.

IBS is characterized by recurrent abdominal pain, often associated with changes in bowel movements. These changes can manifest in various ways, leading to different subtypes of IBS:

  • IBS-C (Constipation-predominant): Characterized by frequent hard or lumpy stools, straining during bowel movements, and infrequent defecation.
  • IBS-D (Diarrhea-predominant): Marked by frequent loose or watery stools, urgency, and sometimes an inability to control bowel movements.
  • IBS-M (Mixed type): Individuals experience both constipation and diarrhea, often alternating between the two.
  • IBS-U (Unclassified/Unspecified): Symptoms don’t fit neatly into the other categories.

Beyond the primary symptoms of pain and altered bowel habits, individuals with IBS often contend with bloating, gas, nausea, and a feeling of incomplete evacuation after a bowel movement. The severity and frequency of these symptoms can vary widely, from mild and occasional to severe and debilitating, significantly lowering the quality of life for those affected.

What Triggers IBS Symptoms?

While the exact cause of IBS remains unknown, several factors are thought to contribute to its development and trigger symptom flare-ups:

  • Dietary Factors: Certain foods can act as triggers. Common culprits include high-FODMAP foods (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols found in many carbohydrates), dairy products, gluten, artificial sweeteners, and fatty foods. We often see that an individualized approach to diet, potentially starting with an elimination diet like a low-FODMAP diet under professional guidance, can bring significant relief.
  • Stress and Psychological Factors: The gut and brain are intimately connected through the gut-brain axis. Stress, anxiety, and depression can significantly influence gut motility and sensitivity, exacerbating IBS symptoms. Managing stress through techniques like meditation, yoga, and adequate sleep is often a crucial component of IBS management.
  • Gut Microbiome Imbalances: Research suggests that an imbalance in gut bacteria (dysbiosis) may play a role in IBS symptoms. Probiotics and prebiotics are sometimes explored to help restore balance.
  • Gastrointestinal Infections: A subset of individuals develops post-infectious IBS following an acute episode of gastroenteritis or food poisoning.
  • Genetics and Hormonal Factors: There appears to be a genetic predisposition for IBS, and hormonal fluctuations, especially in women, can influence symptom presentation.
  • Altered Motility and Visceral Hypersensitivity: The digestive muscles may contract too strongly or too weakly, affecting the speed at which food moves through the gut. Additionally, many IBS patients have heightened pain sensitivity in their gut.

Diagnosing IBS: A Process of Exclusion

Diagnosing IBS typically involves a thorough review of symptoms and a process of exclusion, often guided by the Rome IV diagnostic criteria. Healthcare providers look for recurring abdominal pain, on average, at least one day a week for the past three months, associated with two or more of the following: related to defecation, a change in stool frequency, or a change in stool form.

It’s vital to identify “red flags” that might suggest a more serious underlying condition rather than IBS. These red flags include unexplained weight loss, blood in the stool, anemia, a family history of gastrointestinal cancer or inflammatory bowel disease (IBD), or symptoms that wake a patient from sleep. In such cases, further diagnostic tests are necessary to rule out other conditions like celiac disease, inflammatory bowel disease (Crohn’s or ulcerative colitis), or infections. Only after these possibilities are excluded can a definitive diagnosis of IBS be made. This careful, medically supervised approach is at the heart of how we operate at TrimRx, ensuring that your health journey is built on a foundation of thorough evaluation.

The Rise of GLP-1 Receptor Agonists for Weight Management

In recent years, a groundbreaking class of medications known as GLP-1 receptor agonists (GLP-1 RAs) has revolutionized the landscape of metabolic health and weight management. These medications, including key active ingredients like semaglutide and tirzepatide, have shown remarkable efficacy in both managing type 2 diabetes and promoting significant, sustainable weight loss for many individuals. At TrimRx, we are committed to providing access to these clinically proven solutions, recognizing their potential to transform lives.

How GLP-1 Receptor Agonists Work

GLP-1 RAs mimic the action of a natural hormone in your body called glucagon-like peptide-1 (GLP-1), which is released from the gut in response to food intake. This hormone plays a crucial role in several physiological processes related to metabolism and digestion:

  • Blood Sugar Regulation: GLP-1 stimulates insulin secretion in a glucose-dependent manner, meaning it only releases insulin when blood sugar levels are high. It also suppresses glucagon secretion, which helps prevent the liver from releasing too much sugar.
  • Appetite Suppression and Satiety: GLP-1 acts on receptors in the brain to reduce appetite and increase feelings of fullness, leading to decreased food intake. This helps individuals feel satisfied with smaller portions and reduces cravings.
  • Slowed Gastric Emptying: One of the most significant effects of GLP-1 RAs is slowing down the rate at which food leaves the stomach and enters the small intestine. This prolongs the feeling of fullness and helps regulate post-meal blood sugar spikes.

It’s this slowed gastric emptying, along with reduced appetite, that contributes substantially to the weight loss observed with these medications. For individuals struggling with obesity or overweight conditions, these mechanisms offer a powerful tool to support their weight management goals.

Our Personalized Approach at TrimRx

At TrimRx, our comprehensive weight loss program includes a range of GLP-1 receptor agonists, prescribed as part of a personalized treatment plan determined by a licensed healthcare provider. These options fall into several categories:

It is important to note that while Ozempic®, Wegovy®, Mounjaro®, and Zepbound® are FDA-approved, compounded medications are not FDA-approved. However, we ensure safety and quality by partnering exclusively with FDA-registered and inspected pharmacies for the shipping of all weight loss medications.

To determine eligibility for these prescription medications and receive a personalized treatment plan, we encourage individuals to take our free assessment quiz. This is the first step in our empathetic, innovative approach, allowing our medical professionals to understand your unique health profile and tailor a plan specifically for you. Our comprehensive service includes doctor consultations, necessary lab work, medication, unlimited support throughout your journey, and convenient shipping—all with transparent service and no hidden fees. We believe that sustainable weight loss should be achieved through science, empathy, and a transparent approach, combining advanced medical science with modern technology to deliver compassionate care.

The Intersection: Can You Take Ozempic If You Have IBS?

The question of whether one can take Ozempic if they have IBS is a common and important one, given the widespread use of GLP-1 receptor agonists for weight management and the prevalence of IBS. It requires a careful understanding of how these medications affect the digestive system and how those effects might interact with the sensitive gut of someone with IBS.

GLP-1 receptor agonists, including Ozempic® (semaglutide), are known to cause gastrointestinal side effects. These are often the most commonly reported adverse events, occurring due to the medication’s primary mechanism of slowing gastric emptying. While beneficial for appetite control and blood sugar regulation, this effect can manifest as:

  • Nausea: A very common initial side effect.
  • Vomiting: Can occur, particularly if doses are increased too quickly or if food intake is not adjusted.
  • Diarrhea: Experienced by some individuals.
  • Constipation: Also a frequent complaint, directly linked to slowed gut motility.
  • Abdominal Pain: Can accompany other GI disturbances.

Overlapping Symptoms and Potential Exacerbation

For someone living with IBS, these side effects can present a complex challenge. Many of the GLP-1 induced GI symptoms — nausea, abdominal pain, diarrhea, and especially constipation — directly overlap with core IBS symptoms. This means that a medication designed to help with weight loss could potentially exacerbate existing IBS symptoms, leading to increased discomfort and frustration.

Consider, for example, an individual with IBS-C. If a GLP-1 medication further slows their gastric emptying and overall gut motility, it could intensify their constipation, making bowel movements even more difficult and infrequent. Similarly, someone with IBS-D might experience heightened episodes of diarrhea or abdominal cramping, though constipation is generally reported as a more common GLP-1 side effect than diarrhea. The delicate balance of gut function in IBS patients is particularly susceptible to changes in motility.

Research and Considerations

While research specifically on GLP-1 RAs like Ozempic® in individuals diagnosed with IBS is still emerging and often complex, existing studies on GLP-1 analogs have offered some insights. For instance, a systematic review on the efficacy and safety of GLP-1 receptor agonists in IBS patients, while often focusing on specific experimental analogs like ROSE-010, has noted that such compounds may reduce pain intensity in IBS. However, these benefits were also linked to a higher incidence of side effects like nausea, vomiting, and headache, echoing the general adverse event profile of GLP-1 RAs. This suggests that while GLP-1 pathways might have some influence on IBS-related pain, the overall impact on GI function, particularly concerning motility and potential side effects, requires careful monitoring.

It is crucial to differentiate IBS from Inflammatory Bowel Disease (IBD), such as Crohn’s disease or ulcerative colitis. While GLP-1 medications are generally considered safe for individuals with IBD and some research suggests potential anti-inflammatory benefits in obese IBD patients, the functional nature of IBS means that changes in gut motility from GLP-1 RAs can be perceived differently and potentially lead to more symptom exacerbation in IBS.

Therefore, for individuals contemplating GLP-1 medications like Ozempic® while managing IBS, the decision must be highly individualized and made in close consultation with a healthcare provider. Our empathetic and results-oriented approach at TrimRx emphasizes this personalized care. When you take our free assessment quiz, our medical professionals carefully evaluate your entire health history, including any pre-existing conditions like IBS, to craft a treatment plan that prioritizes your safety and well-being. We believe in transparent service and compassionate care, ensuring that your unique journey is respected and supported every step of the way.

Navigating Potential Side Effects and IBS Management on GLP-1s

For those considering or already using GLP-1 receptor agonists for weight management while also managing Irritable Bowel Syndrome, a proactive and informed approach to managing potential side effects is paramount. Our team at TrimRx understands these challenges and is dedicated to providing the support and guidance necessary to navigate your journey safely and effectively.

Strategies for Managing GLP-1 Related GI Side Effects

The gastrointestinal side effects of GLP-1 RAs, such as nausea, constipation, or diarrhea, often stem from the slowed gastric emptying and changes in gut motility. Here are some strategies that can help alleviate these symptoms:

  1. Hydration is Key: Drinking ample amounts of water throughout the day is crucial. Dehydration can worsen constipation and overall digestive discomfort. Aim for 2-3 liters of water daily, unless otherwise advised by your healthcare provider.
  2. Increase Fiber Intake Gradually: Dietary fiber adds bulk to stool, which can help with constipation. Incorporate both soluble fiber (found in oats, apples, beans, psyllium) and insoluble fiber (found in whole grains, vegetables). However, introduce fiber slowly, as a sudden increase can sometimes exacerbate gas and bloating in IBS patients.
  3. Mindful Eating Practices:
    • Smaller, More Frequent Meals: Instead of three large meals, consider eating four to six smaller meals throughout the day. This can be easier on a stomach with slowed emptying.
    • Eat Slowly: Savor your food and chew thoroughly. Eating too quickly can lead to discomfort.
    • Avoid Overeating: Listen to your body’s fullness cues. GLP-1s help with satiety, so respect those signals.
    • Identify Trigger Foods: Keep a food diary to identify specific foods that worsen your IBS symptoms. Even if a food is generally healthy, it might be an individual trigger.
  4. Consider Meal Timing: Since GLP-1 medications slow gastric emptying, spacing meals out (e.g., four to five hours apart) can prevent a “backed-up” feeling. Some individuals find that taking their GLP-1 medication in the evening helps them sleep through the initial worst of the GI side effects, but this is a personal preference to discuss with your provider.
  5. Stay Physically Active: Regular, gentle exercise like walking, yoga, or swimming can help stimulate bowel movements and reduce constipation. Movement helps get things moving in the gut.
  6. Over-the-Counter (OTC) Remedies:
    • Osmotic Laxatives: Medications like polyethylene glycol (MiraLAX) can draw water into the colon, softening stools without causing dependency.
    • Stool Softeners: Docusate can help if dry, hard stools are the primary issue.
    • Magnesium Oxide: Taking 400 mg of magnesium oxide before bed can be a regular, non-habit-forming option for constipation relief.
    • Antispasmodics: For cramping, your healthcare provider might recommend an antispasmodic medication.
    • Peppermint Oil Supplements: Products containing peppermint oil, like IBgard, have shown promise in alleviating IBS symptoms, including spasms.
  7. Stress Reduction Techniques: Given the strong gut-brain connection, stress can significantly impact both IBS and the perception of GLP-1 side effects. Incorporate stress-reducing activities into your routine, such as meditation, deep breathing exercises, mindfulness, or engaging in hobbies.
  8. Ensure Adequate Sleep: Poor sleep can disrupt gut function and amplify stress, both of which can worsen IBS symptoms. Prioritizing consistent, restorative sleep is vital.

Working with Your TrimRx Care Team

At TrimRx, our commitment to personalized care means that your journey is supported by a dedicated team. If you’re experiencing side effects from your medication or struggling to manage your IBS symptoms while on a GLP-1 RA, we encourage you to utilize our comprehensive service, which includes:

  • Doctor Consultations: Our licensed medical professionals are available to discuss your symptoms, adjust your personalized treatment plan if necessary, and offer medical advice tailored to your unique situation. This includes careful consideration of your IBS history and how to integrate weight loss medication safely.
  • Unlimited Support: We offer continuous support to ensure you feel heard and guided. This unwavering assistance is a cornerstone of our empathetic approach.
  • Lab Work: Regular lab monitoring, when clinically indicated, helps us track your progress and ensure your treatment is both effective and safe.
  • FDA-Registered Pharmacies: We partner exclusively with FDA-registered and inspected pharmacies to ensure the highest quality and safety for the medications shipped to you. Our transparent service remains consistent, regardless of dosage changes or specific medication type.

It’s critical to communicate openly with your TrimRx provider about all your symptoms, especially if they are severe, persistent, or significantly impacting your quality of life. Symptoms like intense abdominal pain, vomiting that won’t stop, or going more than a week without a bowel movement warrant immediate medical attention. We are here to help you navigate these complexities, ensuring that your weight loss journey is not only effective but also aligned with your overall health and well-being, particularly for those managing sensitive conditions like IBS.

Beyond Medication: Holistic Support for Gut Health and Weight Loss

Achieving sustainable weight loss and optimal gut health, especially when navigating a condition like Irritable Bowel Syndrome, extends beyond just medication. It requires a holistic, integrated approach that addresses various facets of your lifestyle, nutrition, and overall well-being. At TrimRx, we believe in empowering individuals with the tools and knowledge to cultivate lasting healthy habits, recognizing that genuine transformation comes from a comprehensive strategy. Our values of innovation, trustworthiness, and support shine through in our commitment to this holistic view.

The Power of Dietary Modifications and Lifestyle Choices

While GLP-1 receptor agonists offer significant support for weight management, they work best when integrated into a lifestyle that actively promotes health. For individuals with IBS, dietary choices are often a cornerstone of symptom management.

  • Personalized Nutrition: There is no one-size-fits-all diet for IBS. Working with a healthcare professional or a dietitian can help you identify your specific food triggers and build a personalized eating plan. Approaches like the low-FODMAP diet, while restrictive, can be highly effective in the short term to identify problematic carbohydrates, followed by careful reintroduction. Similarly, exploring gluten-free or dairy-free options can be beneficial for those with sensitivities that mimic IBS symptoms.
  • Fiber and Hydration: As discussed earlier, adequate fiber intake from whole foods (fruits, vegetables, whole grains, legumes) combined with generous hydration is fundamental for healthy bowel function. This is particularly important when taking GLP-1 medications that can slow digestion.
  • Mind-Body Connection: The gut-brain axis is powerful. Incorporating practices that reduce stress, such as meditation, yoga, mindfulness, or even just regular quiet time, can significantly improve IBS symptoms and contribute to overall well-being. This aligns with our empathetic approach, recognizing the profound link between mental and physical health.
  • Consistent Physical Activity: Regular movement, even moderate exercise like brisk walking, can help regulate gut motility, reduce stress, and support weight loss efforts. It’s a vital component of a healthy lifestyle that complements any medical intervention.
  • Adequate Sleep: Prioritizing 7-9 hours of quality sleep each night is essential. Sleep deprivation can heighten stress, disrupt hormones that regulate appetite, and negatively impact gut function, all of which can impede both weight loss and IBS management.

Enhancing Your Journey with TrimRx Quick-Access Supplements

Understanding that many individuals are looking for immediate support to optimize their health alongside their primary weight loss program or simply to boost their overall wellness, TrimRx offers a range of quick-access supplements. These are available for immediate purchase and are designed to complement your health journey without requiring a personalized assessment quiz. They reflect our commitment to providing diverse, effective solutions rooted in advanced medical science.

  • GLP-1 Daily Support: This supplement is formulated to provide comprehensive support for individuals focusing on metabolic health and weight management. It’s designed to assist with feelings of fullness and contribute to overall digestive comfort, working synergistically with your body’s natural processes.
  • Weight Loss Boost: Created to provide an additional edge in your weight loss efforts, this supplement helps optimize your body’s ability to achieve and maintain a healthy weight, supporting energy levels and metabolism.

These supplements are part of our innovative offerings, crafted to provide tangible benefits for those seeking to enhance their health. They embody our results-oriented approach, providing additional avenues for individuals to feel supported and empowered on their journey to sustainable well-being. We continually strive to blend advanced medical science with modern technology, ensuring that all our products align with our core values of safety, effectiveness, and individualized care.

Making an Informed Decision with TrimRx

Navigating the complexities of weight management, especially when you have a condition like Irritable Bowel Syndrome, requires careful consideration, expert guidance, and a truly personalized approach. The question, “can you take Ozempic if you have IBS,” underscores the need for transparent, medically supervised care that prioritizes your unique health profile.

At TrimRx, our brand is built on being empathetic, innovative, trustworthy, supportive, results-oriented, and personalized. We understand that your journey is unique, and our commitment is to provide compassionate care that respects every individual’s specific needs. We seamlessly combine advanced medical science with modern technology to deliver solutions that are not only effective but also safe and tailored for you.

If you are struggling with weight-related issues and are considering GLP-1 receptor agonists like Ozempic®, Semaglutide, or Tirzepatide, it is essential to undergo a thorough medical evaluation. This is precisely why we’ve designed our process to begin with a crucial first step: our free assessment quiz. This quiz helps us understand your health history, including any conditions like IBS, to determine your eligibility for our prescription weight loss medications and to craft a personalized treatment plan that aligns with your specific health needs and goals.

Our comprehensive service ensures that you receive holistic support at every stage:

  • Expert Doctor Consultations: Our licensed medical professionals are here to provide personalized guidance, addressing your concerns about IBS and other health conditions while developing a safe and effective weight loss strategy.
  • Essential Lab Work: When clinically indicated, we facilitate necessary lab tests to ensure your treatment plan is appropriate and monitored for safety and efficacy.
  • Medication Delivered to Your Door: We partner exclusively with FDA-registered and inspected pharmacies for the shipping of all weight loss medications. This ensures the highest standards of safety and quality for our products. Please remember, while branded medications like Ozempic® and Zepbound® are FDA-approved, compounded medications are not, and we communicate this distinction clearly.
  • Unlimited Support: Our dedicated care team offers ongoing support, answering your questions and providing encouragement throughout your journey. Our approach remains consistent regardless of dosage changes, reflecting our commitment to transparent and reliable service.
  • No Hidden Fees: We believe in clarity and honesty, ensuring you understand exactly what your program entails without any surprises.

We believe that sustainable weight loss should be achieved through science, empathy, and a transparent approach. By engaging with our personalized program, you are choosing a path that puts your health and well-being at the forefront, guided by medical expertise and unwavering support.

Beyond our prescription programs, we also offer immediate support through our quick-access supplements. To boost your overall wellness during your weight loss journey, explore our GLP-1 Daily Support and Weight Loss Boost supplements, available for immediate purchase. These products are designed to complement a healthy lifestyle and are part of our broader commitment to your well-being.

Conclusion

The journey to sustainable weight loss, particularly for individuals navigating the complexities of Irritable Bowel Syndrome, demands a nuanced and highly personalized approach. While GLP-1 receptor agonists like Ozempic® offer significant potential for weight management, understanding their interaction with a sensitive gut is paramount. We’ve explored how these medications function, the overlapping nature of their potential side effects with IBS symptoms, and the critical importance of a medically supervised strategy to manage these interactions.

At TrimRx, we stand firm in our belief that safe and effective weight loss is achievable through a combination of cutting-edge science, deep empathy, and transparent processes. We offer personalized, medically supervised programs designed to address your unique health profile, ensuring that every step of your journey is guided by expertise and compassionate care. Our commitment to partnering with FDA-registered and inspected pharmacies underscores our dedication to your safety and the quality of the medications you receive.

We encourage you to take the first proactive step towards a healthier future. Discover if our personalized weight loss solutions are right for you by completing our free assessment quiz today. For immediate support in optimizing your wellness, consider exploring our GLP-1 Daily Support and Weight Loss Boost supplements. Together, we can build a path towards lasting health and well-being, tailored specifically to you.

FAQ

What are the most common gastrointestinal side effects of Ozempic® and other GLP-1 RAs?

The most common gastrointestinal side effects associated with Ozempic® and other GLP-1 receptor agonists include nausea, vomiting, diarrhea, constipation, and abdominal pain. These symptoms are primarily due to the medication’s effect of slowing down gastric emptying, which helps with appetite control but can alter gut motility.

How does Ozempic® affect gut motility, and why is this relevant for someone with IBS?

Ozempic® slows gastric emptying, meaning food moves more slowly through the digestive tract. For someone with IBS, this slowed motility can be particularly relevant because IBS is characterized by altered gut function. If you have IBS-C (constipation-predominant IBS), further slowing of motility could exacerbate constipation. If you have IBS-D (diarrhea-predominant IBS), the changes in motility could potentially trigger different symptoms or worsen existing ones, although constipation is a more commonly reported side effect. Careful medical supervision, as offered through our personalized assessment, is essential.

Are there specific dietary or lifestyle adjustments that can help manage IBS symptoms while taking a GLP-1 RA?

Yes, several adjustments can help. Increasing hydration, gradually incorporating both soluble and insoluble fiber, eating smaller and more frequent meals, and avoiding known trigger foods (such as high-FODMAP items, dairy, or gluten if sensitive) can be beneficial. Additionally, managing stress through mindfulness or exercise, and ensuring adequate sleep, are crucial for both IBS management and overall well-being. Our program includes unlimited support to help you integrate these changes.

When should I consult a healthcare provider if I experience severe GI symptoms on a GLP-1 RA with IBS?

You should consult your TrimRx healthcare provider immediately if you experience severe or persistent gastrointestinal symptoms such as intense, unremitting abdominal pain, continuous vomiting, or if you have not had a bowel movement for more than a week. These symptoms could indicate a more serious issue and require prompt medical evaluation. Our comprehensive service includes doctor consultations for such situations.

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