Navigating Your Journey: Is Mounjaro One Pen Per Week the Right Schedule for You?

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48 min
Published on
December 18, 2025
Updated on
December 18, 2025
Navigating Your Journey: Is Mounjaro One Pen Per Week the Right Schedule for You?

Introduction

Imagine the profound shift in wellness that can come from a carefully considered, personalized approach to health. For many individuals navigating the complexities of weight management and blood sugar regulation, a weekly routine can be a beacon of consistency. In recent years, medications like Mounjaro (tirzepatide) have emerged as significant advancements, offering a once-weekly injection schedule that simplifies adherence and integrates more smoothly into daily life. This specific dosing frequency—the idea of “one pen per week”—is a common point of discussion and often raises questions about its practical application and effectiveness.

This comprehensive guide will delve into the intricacies of Mounjaro’s once-weekly dosing, exploring not just how it’s administered, but why this schedule is designed the way it is. We will illuminate the mechanisms behind tirzepatide, detail the proper usage and storage of Mounjaro pens, and discuss what to expect as you embark on a treatment journey. Our purpose is to demystify the “one pen per week” routine, providing clarity and confidence for those considering or currently using this medication. By the end of this post, you will have a deeper understanding of Mounjaro’s role in a holistic health strategy and how a personalized, medically supervised program can support your individual goals. We believe that sustainable weight loss should be achieved through science, empathy, and a transparent approach, and we are here to offer insights into making informed decisions about your health.

Understanding Mounjaro: A Dual-Action Approach to Metabolic Health

Mounjaro, the brand name for tirzepatide, represents a significant stride in the treatment of type 2 diabetes and a promising option for weight management. Its unique efficacy stems from its dual-action mechanism, which targets two key incretin hormones in the body: Glucagon-Like Peptide-1 (GLP-1) and Glucose-Dependent Insulinotropic Polypeptide (GIP). This innovative approach sets it apart from medications that only target one of these receptors.

How Tirzepatide Works

The GLP-1 and GIP receptors play crucial roles in metabolic regulation. When activated by tirzepatide, they work synergistically to:

  • Enhance Insulin Secretion: Mounjaro stimulates the pancreas to release more insulin in response to elevated blood sugar levels. This effect is glucose-dependent, meaning it primarily acts when blood sugar is high, thereby reducing the risk of hypoglycemia (low blood sugar) when used as a standalone therapy.
  • Reduce Glucagon Secretion: Glucagon is a hormone that raises blood sugar. By decreasing glucagon production, Mounjaro helps to lower glucose levels, particularly between meals and overnight.
  • Slow Gastric Emptying: The medication slows down the rate at which food leaves the stomach. This contributes to a feeling of fullness, which can lead to reduced food intake and, consequently, weight loss.
  • Promote Satiety: By influencing hunger signals in the brain, tirzepatide helps to curb appetite and reduce cravings, further supporting weight management efforts.

This comprehensive action on both blood sugar control and satiety mechanisms positions Mounjaro as a powerful tool for individuals seeking to improve their metabolic health. At TrimRx, we recognize the transformative potential of such clinically proven solutions. Our journey began with a shared vision to help individuals embrace healthier lifestyles by merging cutting-edge telehealth innovations with effective weight loss solutions. We understand that effective weight management often requires a multifaceted approach, and medications like tirzepatide can be a cornerstone of such plans.

The “One Pen Per Week” Protocol: Dosing and Administration

The question “is mounjaro one pen per week” refers to the core dosing regimen for this medication. Mounjaro is indeed designed for once-weekly administration, offering a convenient and consistent schedule that can significantly enhance treatment adherence. This section will clarify what “one pen per week” entails in practice.

The Mounjaro Pen: Single-Dose Simplicity

For many individuals, Mounjaro is provided in a pre-filled, single-dose pen. This means that each pen contains one precisely measured dose of the medication, ready for injection. The design prioritizes ease of use: there’s no need for mixing, and the needle is typically hidden during the injection process, which can alleviate apprehension for those new to injectables.

The instruction “is mounjaro one pen per week” directly applies here: you will use one pen for your weekly injection. For a typical month’s supply, you would receive four such pens, each containing the same prescribed dose. It’s crucial to always check the pen label and carton to ensure the correct medicine name and dose strength match your prescription, especially as doses may change over time.

The Mounjaro KwikPen: A Multi-Dose Alternative

While many refer to “one pen per week” in the context of single-dose pens, it’s worth noting that Mounjaro is also available in a multi-dose pre-filled pen called the Mounjaro KwikPen in some regions. This specific pen type contains four full doses, designed to deliver one dose weekly over a month. So, while it’s still “one dose per week,” a single KwikPen can cover a month’s supply of injections. Regardless of the pen type, the core principle remains: a single injection is administered once per week.

Choosing Your Injection Day and Site

Consistency is key with Mounjaro. You should administer your injection once a week, on the same day, at any time of the day, with or without food. Establishing a routine can be incredibly helpful; many individuals find setting a reminder on their phone beneficial to maintain their “Mounjaro day.”

Life happens, and schedules can change. If you need to adjust your injection day, you can do so, but it’s important to ensure there are at least 3 days (72 hours) between doses. This spacing is vital for the medication’s efficacy and your safety.

As for injection sites, Mounjaro can be injected into the abdomen (stomach), thighs, or the back of the upper arms. Your healthcare provider can help you determine the best site for you. If injecting into the back of the upper arm, another person should assist you. It’s important to rotate your injection site with each dose. For example, if you inject into your abdomen one week, consider using your thigh or the other side of your abdomen the next week. This helps prevent skin problems and ensures consistent absorption of the medication.

Step-by-Step Injection Process Overview

While your healthcare provider will provide detailed, hands-on training, understanding the general steps can be reassuring:

  1. Prepare: Gather your Mounjaro pen and a sharps container. Ensure the pen is at room temperature if it’s been out of refrigeration for the allowed period.
  2. Inspect: Check the pen for any damage and confirm the medication is clear and colorless.
  3. Choose Site: Select your injection site and clean it with an alcohol swab.
  4. Remove Cap: Pull off the base cap of the pen.
  5. Position and Unlock: Place the pen’s base flat against your skin, then unlock it if required by your specific pen model.
  6. Inject: Press and hold the button for up to 10 seconds. You’ll typically hear a first click indicating the injection has started, and a second click signifying it’s complete. Hold the pen in place until the second click is heard and the dose indicator shows zero.
  7. Dispose: Immediately place the used pen in a sharps container.

It is paramount to read the Instructions for Use (IFU) that come with your specific Mounjaro pen and to receive proper training from your healthcare provider before your first injection.

Starting Your Mounjaro Journey: Dose Escalation and Monitoring

Beginning any new medication, especially one like Mounjaro, involves a carefully structured approach. The initial phases of treatment are designed to allow your body to gradually adjust to the medication, minimizing potential side effects while working towards an effective dose.

The Typical Titration Schedule

Mounjaro treatment typically starts with a lower dose to help your body acclimate. Most individuals begin with a 2.5 mg once-weekly dose for the first four weeks. This foundational period allows your system to get used to the medication’s effects.

After these initial four weeks, your healthcare provider will usually increase your dose to 5 mg once weekly. The dose is then typically escalated every four weeks thereafter, in increments of 2.5 mg (e.g., to 7.5 mg, 10 mg, 12.5 mg, and finally 15 mg), until an optimal maintenance dose is reached. This personalized approach ensures that you receive the most effective dose that you can tolerate well. It’s not a race to the highest dose, but rather a methodical progression guided by your individual response and side effect profile.

Throughout this titration process, open communication with your healthcare provider is essential. They will monitor your progress, assess any side effects you might experience, and make adjustments to your dosage as needed. This tailored care is central to TrimRx’s philosophy; we believe in compassionate care that respects every individual’s unique journey, combining advanced medical science with modern technology.

The Importance of Medical Supervision

While the “one pen per week” schedule simplifies administration, the journey itself is far from set-and-forget. Medically supervised care is critical to ensure safety and effectiveness, particularly during dose adjustments. Our platform at TrimRx connects you with healthcare professionals who can provide this essential oversight. Through comprehensive services that include doctor consultations, necessary lab work, and unlimited support, we aim to make sustainable weight loss attainable and tailored to your individual needs. We also partner exclusively with FDA-registered and inspected pharmacies for the shipping of weight loss medications, ensuring that you receive products from trusted sources.

As your body adapts to Mounjaro, your healthcare provider will assess its impact on your blood sugar levels (if you have type 2 diabetes) and your weight management goals. They may also discuss strategies for managing any side effects that arise, helping you navigate the treatment path smoothly.

To see if a personalized treatment plan with medications like Mounjaro or other GLP-1/GIP receptor agonists might be suitable for you, we encourage you to take our free assessment quiz. This initial step helps us understand your health profile and determine your eligibility for our prescription weight loss medications.

Storing Your Mounjaro Pens: Ensuring Efficacy and Safety

Proper storage of your Mounjaro pens is paramount to maintaining the medication’s potency and ensuring your safety. Following specific guidelines will protect your pens from damage and preserve the active ingredients.

Refrigeration is Key

Mounjaro pens should ideally be stored in the refrigerator at a temperature between 36°F to 46°F (2°C to 8°C). This cool environment helps maintain the stability and effectiveness of tirzepatide. Always keep the pens in their original packaging until you are ready to use them. This carton provides crucial protection from light, which can degrade the medication.

It’s important to remember a few key points about refrigerated storage:

  • Avoid Freezing: Under no circumstances should Mounjaro pens be frozen. If the medicine inside a pen gets frozen, it should not be used, even if it thaws. Freezing can alter the medication’s composition and render it ineffective or unsafe.
  • Handle with Care: The pens contain glass parts, so gentle handling is necessary. If a pen is dropped on a hard surface, it should not be used, even if it appears undamaged. Always use a new pen in such a situation.
  • Refrigerator Placement: Be mindful that temperatures can vary within a refrigerator. The back of some refrigerators can be colder, potentially risking freezing. Storing pens on a middle shelf, away from the back, is often a good practice. Always double-check your pen to ensure it has not frozen before administering your injection.

Travel and Temporary Storage

Life doesn’t stop for medication, and we understand the need for flexibility. If you are traveling or need to store your Mounjaro pens outside of refrigeration temporarily, there are guidelines to follow:

Mounjaro can be kept unrefrigerated for up to 21 days, as long as the temperature does not exceed 86°F (30°C). During this time, it’s still crucial to keep the pen in its original carton to protect it from light. If you are going on a trip, consider using a cool bag or a cooling medication device if you wish to maintain refrigeration, especially for longer journeys or in warmer climates. Always check with your airline regarding regulations for carrying medications, particularly injectables, in hand luggage. It’s also advisable to carry proof of your prescription.

After 21 days at room temperature, any unrefrigerated pen must be discarded, even if it still contains medication. It’s helpful to mark the date you remove a pen from refrigeration to keep track.

Expiry Dates and Damaged Pens

Like all medications, Mounjaro pens have an expiry date, which is printed on the pen label and carton (look for “EXP”). This date refers to the last day of the month indicated. Never use a Mounjaro pen past its expiry date, as its efficacy and safety cannot be guaranteed.

If you notice your Mounjaro pen is broken or damaged in any way, do not use it. Speak to your medicine supplier or pharmacist for guidance on safe disposal and to obtain a replacement. We work with FDA-registered and inspected pharmacies to ensure the integrity and safe delivery of all medications.

By adhering to these storage guidelines, you contribute significantly to the consistent effectiveness and safety of your Mounjaro treatment.

Navigating Potential Side Effects with Mounjaro

While Mounjaro offers significant benefits for blood sugar control and weight management, it’s important to be aware of potential side effects. Most side effects are gastrointestinal (GI) in nature and tend to be more common when starting treatment or during dose increases, typically decreasing over time as your body adjusts. Our commitment to transparent service means providing you with a clear understanding of what to expect.

Common Side Effects

The most frequently reported side effects associated with Mounjaro include:

  • Nausea
  • Diarrhea
  • Decreased appetite
  • Vomiting
  • Constipation
  • Indigestion
  • Stomach pain

If you experience nausea, several strategies can help manage it. Consider eating smaller meals more frequently instead of three large ones. Stop eating when you feel full, even if it’s a small portion. Avoiding fatty or greasy foods can also be beneficial, as these can exacerbate GI upset. Opting for bland foods like toast, crackers, or rice can often provide relief. Staying well-hydrated is also crucial, so remember to drink water often. If nausea or any other side effect becomes bothersome or persists, it’s vital to discuss it with your healthcare provider.

Serious Side Effects and Important Safety Information

While less common, certain serious side effects warrant immediate medical attention. It’s crucial to be informed about these to ensure your safety:

  • Severe Stomach Problems: Mounjaro can, in some cases, cause severe stomach problems. If you experience stomach pain that is severe or does not go away, inform your healthcare provider immediately.
  • Pancreatitis: This is an inflammation of the pancreas, which can be serious. Symptoms include severe stomach pain that may radiate to your back, with or without vomiting. If you suspect pancreatitis, seek urgent medical care.
  • Gallbladder Problems: Some individuals may develop gallbladder issues, including gallstones. Symptoms can include severe pain in the upper right abdomen, fever, nausea, and vomiting.
  • Thyroid C-Cell Tumors: Mounjaro has a boxed warning regarding the risk of thyroid C-cell tumors. It should not be used in individuals with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Report any new lumps or swelling in your neck, hoarseness that doesn’t go away, trouble swallowing, or shortness of breath to your provider.
  • Kidney Problems: Dehydration due to severe vomiting or diarrhea can sometimes lead to kidney injury. Staying hydrated is essential.
  • Severe Allergic Reactions: While rare, a severe allergic reaction (anaphylaxis) is possible. Symptoms include rash, itching, hives, swelling of your face, lips, tongue, or throat, or trouble breathing. Seek emergency medical attention if this occurs.

Before starting Mounjaro, it is imperative to discuss your full medical history with your healthcare provider, including any history of pancreatitis, gallbladder disease, kidney problems, or personal/family history of thyroid cancer. Also, inform all your healthcare providers that you are taking Mounjaro before any scheduled surgery or procedures, as it may increase the chance of food getting into your lungs during anesthesia.

Our brand is empathetic, trustworthy, and supportive. We want you to feel confident and informed throughout your weight loss journey. Our comprehensive service includes unlimited support, meaning you can reach out with questions or concerns about side effects. Always remember, while we provide extensive information, it complements, but does not replace, the personalized advice of your doctor.

Who Can Benefit from Mounjaro? Eligibility and Considerations

Determining if Mounjaro is an appropriate treatment involves a careful assessment of an individual’s health profile, medical history, and specific health goals. This medication is primarily approved for adults with type 2 diabetes mellitus to improve blood sugar (glucose) in conjunction with diet and exercise. However, its effectiveness in weight management has also made it a significant topic of discussion for individuals struggling with obesity.

Mounjaro for Type 2 Diabetes

For adults living with type 2 diabetes, Mounjaro works by stimulating insulin release and reducing glucagon production, thereby lowering blood sugar levels and improving HbA1c (a measure of average blood sugar over 2-3 months). It is often considered when other treatment regimens, including lifestyle interventions and other medications, have not been sufficiently effective in managing diabetes.

Healthcare guidelines in various regions, for instance, may recommend Mounjaro for adults with type 2 diabetes when:

  • Multiple medications have not achieved adequate diabetes management.
  • Other medications are not tolerated due to side effects or contraindications.
  • The individual also has a certain Body Mass Index (BMI) and additional psychological or other medical conditions related to obesity.

Your healthcare provider will conduct a thorough evaluation to determine if Mounjaro fits into your current diabetes management plan and can help you achieve your blood sugar targets.

Mounjaro for Weight Management

Beyond its primary indication, Mounjaro (tirzepatide) has shown impressive results in clinical trials for weight loss in individuals with obesity or overweight with weight-related co-morbidities. While specific availability and prescribing criteria for weight loss can vary by region and healthcare system, the general principles often involve:

  • BMI Thresholds: Typically, individuals with a BMI of 30 kg/m² or higher (indicating obesity) or a BMI of 27 kg/m² or higher (indicating overweight) with at least one weight-related condition (e.g., high blood pressure, high cholesterol, obstructive sleep apnea, type 2 diabetes) may be considered.
  • Related Health Conditions: The presence of co-morbidities significantly strengthens the case for considering Mounjaro for weight loss, as reducing weight can dramatically improve these conditions.
  • Racial and Ethnic Considerations: Some guidelines acknowledge that certain racial and ethnic groups (e.g., Black African, African-Caribbean, Asian, South Asian, Chinese, and Middle Eastern backgrounds) may be at higher risk for obesity-related health problems at lower BMI thresholds and thus may be considered for treatment earlier.

It’s important to understand that Mounjaro for weight loss is part of a comprehensive program that includes dietary changes and increased physical activity. It is not a standalone solution but a tool to support and enhance weight loss efforts.

The TrimRx Approach to Personalized Eligibility

At TrimRx, we are dedicated to safe, effective weight loss and individualized care. We understand that your journey is unique, and that’s why we emphasize a personalized assessment. Our platform is a user-friendly and supportive space where individuals receive personalized, medically supervised care. We offer a range of clinically proven options, including Mounjaro (branded tirzepatide), [Compounded Tirzepatide] and [Oral Tirzepatide], as well as Semaglutide options like [Compounded Semaglutide], [Oral Semaglutide], [Ozempic®], and [Wegovy®], and [Zepbound®].

To determine if you qualify for these prescription weight loss medications and to receive a tailored treatment plan, we invite you to take our free assessment quiz. This assessment helps our affiliated healthcare professionals understand your health history, current condition, and weight loss goals to recommend the most appropriate path forward. Remember, our approach remains consistent regardless of dosage changes, focusing on your safety and results. We partner exclusively with FDA-registered and inspected pharmacies for the shipping of these medications, ensuring quality and peace of mind.

Integrating Mounjaro into a Holistic Weight Loss and Wellness Program

While Mounjaro’s “one pen per week” dosing offers powerful support for weight management and metabolic health, it thrives best as part of a comprehensive, holistic wellness strategy. True sustainable weight loss is rarely achieved through medication alone; it requires a synergy of lifestyle changes, consistent support, and medical guidance.

Beyond the Needle: Diet and Exercise

The foundation of any successful weight loss journey, even with medication like Mounjaro, remains a balanced diet and regular physical activity. Mounjaro works by supporting your body’s natural satiety signals and metabolic processes, making it easier to adhere to healthier eating habits and reduce overall caloric intake. This is where personalized nutrition plans and exercise routines become incredibly valuable.

  • Nutritional Guidance: Focus on nutrient-dense foods, including lean proteins, whole grains, fruits, and vegetables. These foods not only provide essential nutrients but also contribute to feelings of fullness. Avoiding highly processed foods, sugary drinks, and excessive unhealthy fats can maximize the benefits of Mounjaro by supporting overall metabolic health. Your healthcare provider or a registered dietitian can offer tailored dietary advice that complements your Mounjaro treatment.
  • Physical Activity: Incorporating regular physical activity, whether it’s brisk walking, strength training, or a favorite sport, helps to burn calories, build muscle mass, improve cardiovascular health, and boost mood. Even small increases in activity can make a big difference. Discuss with your healthcare provider the safest and most effective exercise regimen for your current health status.

At TrimRx, we emphasize that our personalized weight loss programs are designed to integrate these crucial lifestyle elements. Our platform provides a supportive environment where medical supervision meets practical advice, helping you make sustainable changes that extend beyond medication.

The Value of Comprehensive Support and Resources

Navigating a weight loss journey can be challenging, and having a robust support system can make all the difference. This is where TrimRx truly excels. Our comprehensive service is built on the principles of empathy, innovation, and unwavering support. When you embark on a personalized program with us, you don’t just receive medication; you gain a partner in your health.

Our offerings include:

  • Doctor Consultations: Regular check-ins with affiliated healthcare professionals ensure your treatment plan is optimized for your progress and any concerns are promptly addressed.
  • Lab Work: Necessary lab tests are included to monitor your health markers and ensure the medication is working effectively and safely.
  • Unlimited Support: Our team is here for you every step of the way, ready to answer your questions, offer encouragement, and help you overcome obstacles. This continuous support is vital for long-term success.
  • Shipping with No Hidden Fees: We ensure transparent service, partnering with FDA-registered and inspected pharmacies to deliver your medications directly to you without unexpected costs.

We understand that a personalized, medically supervised weight loss program can transform lives. Our commitment is to empower you with the tools and guidance needed for sustainable health improvements.

Enhancing Your Journey with Quick-Access Supplements

Beyond prescription medications, we also offer quick-access supplements designed to support your overall wellness during your weight loss journey. These supplements do not require a prescription or our assessment quiz and are available for immediate purchase.

  • GLP-1 Daily Support: This supplement is formulated to complement your GLP-1/GIP-based therapy by providing additional nutritional support that can aid in digestion, metabolism, and overall well-being.
  • Weight Loss Boost: Designed to provide an extra edge, this supplement can help enhance your body’s natural fat-burning processes and energy levels, contributing to more effective weight loss when combined with diet and exercise.

These supplements offer convenient ways to support your body’s needs and can be an excellent addition to your regimen, whether you’re on a prescription medication like Mounjaro or focusing on lifestyle changes.

Ultimately, Mounjaro’s “one pen per week” routine is a powerful component, but it’s the personalized, medically supervised framework—like the one we offer at TrimRx—that maximizes its potential. Our goal is to blend advanced medical science with modern technology to deliver results-oriented, empathetic care, helping you achieve your healthiest self. If you’re ready to explore a comprehensive, tailored approach to weight loss, we encourage you to take our free assessment quiz today.

Conclusion

The journey towards sustainable weight loss and improved metabolic health is deeply personal, yet it is often shared by a common desire for effective, safe, and manageable solutions. Mounjaro, with its convenient “one pen per week” dosing schedule, represents a significant advancement, offering a dual-action approach that supports both blood sugar regulation and weight management. We’ve explored how this innovative medication works by targeting GLP-1 and GIP receptors, its typical once-weekly administration, and the importance of proper storage and careful dose escalation under medical guidance.

Understanding the nuances of Mounjaro, from its single-dose pen to potential side effects and the critical role of medical supervision, is essential for anyone considering or currently using this treatment. We recognize that medication is just one piece of the puzzle. The true power lies in integrating such therapies into a holistic wellness program that includes personalized diet, consistent exercise, and unwavering support.

At TrimRx, our foundation is built on empathy, innovation, and trust. Our commitment is to provide you with a transparent and supportive platform for your weight loss journey. Through our comprehensive services—including doctor consultations, necessary lab work, unlimited support, and safe shipping from FDA-registered and inspected pharmacies—we strive to make your path to healthier living both attainable and sustainable. Whether you are exploring prescription options like Mounjaro or seeking to enhance your wellness with our quick-access supplements like GLP-1 Daily Support and Weight Loss Boost, we are here to support you.

We believe that every individual deserves a personalized approach that honors their unique needs and challenges. Your health journey is our shared mission. If you’re ready to take the next step towards a healthier, more vibrant you, we invite you to take our free assessment quiz to explore how a medically supervised and personalized weight loss program could transform your life.

Frequently Asked Questions

What does “is Mounjaro one pen per week” mean for my dosing schedule?

Mounjaro is typically administered as a once-weekly injection. For many, this means using one single-dose pre-filled pen each week. Some variations, like the Mounjaro KwikPen, contain four weekly doses within a single pen for a month’s supply. Regardless of the pen type, the core instruction is one injection per week, ideally on the same day.

What should I do if I miss a dose of Mounjaro?

If you miss a Mounjaro dose, take it as soon as possible, provided it is within 4 days (96 hours) of your regularly scheduled dose. If more than 4 days have passed, you should skip the missed dose and resume your regular schedule on your next planned injection day. Crucially, do not take two doses of Mounjaro within 3 days (72 hours) of each other.

How should I store my Mounjaro pens to ensure their effectiveness?

Mounjaro pens should be stored in the refrigerator between 36°F to 46°F (2°C to 8°C) in their original carton to protect them from light. Do not freeze Mounjaro pens; if a pen has been frozen, it should not be used. If needed, a pen can be stored unrefrigerated for up to 21 days at a temperature not exceeding 86°F (30°C), but it must be discarded after this period or by its expiry date, whichever comes first.

Can I change the day of the week I take my Mounjaro injection?

Yes, you can change your Mounjaro injection day if needed. However, it’s essential to ensure there are at least 3 days (72 hours) between the last dose you took and the new dose you plan to take. This ensures appropriate spacing and helps maintain the medication’s effectiveness. Once you’ve chosen a new day, try to stick to it consistently each week.

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