Longevity

Ipamorelin works by binding the growth hormone secretagogue receptor type 1a (GHS-R1a), commonly called the ghrelin receptor.

Ipamorelin has a more substantial pharmaceutical research history than most peptides in the wellness category.

Introduction Ipamorelin dosing in adult off-label use has converged on a few standard protocols across 503A compounding pharmacies and peptide-prescribing clinical practices. The most…

Ipamorelin is a synthetic pentapeptide (five amino acids) developed in the late 1990s as a selective growth hormone secretagogue.

The question of stacking humanin with semaglutide or tirzepatide comes up in telehealth clinics that offer both. The mechanistic story is plausible.

Humanin has one of the more complex mechanism stories in the peptide world. It does not act on a single receptor with a single downstream effect.

Humanin research spans more than two decades.

Humanin dosing in clinical practice is largely empirical. There is no published phase 2 dose finding study in humans for any indication.

Introduction Humanin was the first identified mitochondrial derived peptide, reported by Hashimoto and colleagues in 2001 from a cDNA library of neurons that survived…