GLP-1 Weight Loss Programs: Complete Beginner’s Guide for 2026

GLP-1 weight loss programs use medications that mimic a natural hormone your body produces to regulate appetite and blood sugar, producing 10-22% average body weight loss, results previously only achievable through bariatric surgery. 

If you’re considering GLP-1 therapy but feeling overwhelmed by information about Ozempic, Wegovy, Mounjaro, and other options, this comprehensive guide explains everything you need to know to make informed decisions about starting treatment.

GLP-1 medications have revolutionized weight loss treatment by addressing the biological mechanisms that make weight loss difficult. Rather than relying solely on willpower and calorie restriction, these medications work with your body’s natural hunger and satiety signals to make sustainable weight loss achievable. 

TrimRx provides accessible GLP-1 therapy through licensed providers, offering both compounded semaglutide at $199/month and compounded tirzepatide at $349/month with complete medical support.

Key Takeaways:

• GLP-1 medications produce 10-22% average body weight loss over 16-20 months
• Weekly injections using small needles are easier than most people expect
• Side effects like nausea are common initially but typically improve within 4-8 weeks
• Long-term use is necessary to maintain weight loss results
• Compounded options make effective treatment affordable ($199-$349/month vs $1,000+)
• Telehealth access allows you to start treatment entirely online without in-person visits

What Are GLP-1 Medications?

GLP-1 (glucagon-like peptide-1) medications are a class of drugs that mimic a natural hormone your intestines produce after eating, helping regulate appetite, blood sugar, and metabolism.

The Science Behind GLP-1:

Natural GLP-1 Hormone:

Your body naturally produces GLP-1 in your intestines when you eat. This hormone:

• Signals your brain that you’re full and satisfied
• Tells your pancreas to release insulin to manage blood sugar
• Slows down how quickly food leaves your stomach
• Reduces appetite and food cravings
• Helps prevent your liver from releasing excess glucose

The Problem: Natural GLP-1 only lasts a few minutes before enzymes break it down. It works while you’re eating and shortly after, but the effects disappear quickly.

GLP-1 Medications Are Different:

Pharmaceutical GLP-1 medications are synthetic versions engineered to:

• Last much longer in your body (days instead of minutes)
• Resist breakdown by enzymes
• Maintain therapeutic levels continuously
• Produce stronger, sustained effects than natural GLP-1

Think of it this way:

• Natural GLP-1: Brief “I’m full” signal during meals
• GLP-1 medications: Continuous “you’re satisfied, don’t overeat” signal all week

Types of GLP-1 Medications:

Pure GLP-1 Receptor Agonists: These activate only GLP-1 receptors:

Semaglutide:

• Brand names: Wegovy (weight loss), Ozempic (diabetes)
• Dosing: Once weekly injection
• Average weight loss: 10-15% of body weight
• FDA approved: 2017 (Ozempic), 2021 (Wegovy)

Liraglutide:

• Brand name: Saxenda (weight loss), Victoza (diabetes)
• Dosing: Daily injection
• Average weight loss: 5-8% of body weight
• Older, less effective than semaglutide

Dulaglutide:

• Brand name: Trulicity
• Dosing: Once weekly injection
• Primarily for diabetes, not typically used for weight loss

Dual GIP/GLP-1 Receptor Agonist:

Tirzepatide:

• Brand names: Zepbound (weight loss), Mounjaro (diabetes)
• Dosing: Once weekly injection
• Average weight loss: 15-22% of body weight
• FDA approved: 2022 (Mounjaro), 2023 (Zepbound)
• Most effective weight loss medication available

What Makes Tirzepatide Different:

Tirzepatide activates two hormone receptors instead of one:

GLP-1 Effects (same as semaglutide):

• Appetite suppression
• Slowed stomach emptying
• Increased insulin secretion
• Reduced glucagon production

Plus GIP Effects:

• Enhanced insulin response
• Improved insulin sensitivity
• Effects on fat metabolism
• Additional appetite suppression

Result: 5-7% more weight loss than semaglutide alone, making tirzepatide the most effective option.

How GLP-1 Medications Differ from Other Weight Loss Drugs:

Traditional Weight Loss Medications:

• Stimulants (phentermine): Increase energy, suppress appetite through adrenaline-like effects
• Fat blockers (orlistat): Prevent fat absorption in intestines
• Combination pills (Contrave, Qsymia): Multiple mechanisms, moderate effectiveness

These produce 3-9% average weight loss at best.

GLP-1 Medications:

• Work with natural hunger hormones
• Multiple complementary mechanisms
• Target biological causes of overeating
• Produce 10-22% average weight loss
• Much more effective than traditional options

Medical Uses:

FDA-Approved Indications:

For Type 2 Diabetes:

• All GLP-1 medications originally approved for diabetes
• Improve blood sugar control
• Reduce A1C by 1-2 percentage points
• Lower risk of cardiovascular events

For Chronic Weight Management:

• Semaglutide (Wegovy): Approved 2021
• Tirzepatide (Zepbound): Approved 2023
• Liraglutide (Saxenda): Approved 2014

Requirements for weight loss approval:

• BMI ≥30, or
• BMI ≥27 with weight-related condition (diabetes, hypertension, sleep apnea, etc.)

Off-Label Use:

Many doctors prescribe diabetes versions (Ozempic, Mounjaro) off-label for weight loss because:

• Identical medication to weight loss versions
• Sometimes better insurance coverage
• Same effectiveness regardless of indication on label

This is legal and common medical practice.

Common Brand Names Explained:

The same medication often has multiple brand names:

Semaglutide = Multiple Brands:

• Wegovy: Weight loss indication
• Ozempic: Diabetes indication
• Rybelsus: Oral tablet for diabetes (less effective)

Tirzepatide = Multiple Brands:

• Zepbound: Weight loss indication
• Mounjaro: Diabetes indication

The medication is identical—only the labeled indication differs.

Compounded GLP-1 Medications:

What “Compounded” Means:

Licensed pharmacies can prepare GLP-1 medications from pharmaceutical-grade ingredients:

• Same active ingredient as brand-name
• Made by FDA-registered compounding pharmacies
• Follows strict sterile compounding standards
• Much more affordable ($199-$349/month vs $1,000+)

Legal Status:

• Completely legal when FDA-registered pharmacies prepare them
• Permitted because brand-name versions are on FDA shortage list
• Require valid prescription from licensed provider

Effectiveness:

• Same active ingredient = same effectiveness
• Clinical results identical to brand-name when properly compounded

TrimRx provides access to compounded options that make effective GLP-1 therapy affordable for cash-pay patients.

Why GLP-1 Medications Work So Well:

They Address the Real Problem:

Most weight loss approaches fail because they fight against your body’s biology:

• Calorie restriction triggers stronger hunger signals
• Your metabolism slows to conserve energy
• Cravings intensify as weight decreases
• Willpower alone can’t overcome these biological responses

GLP-1 medications work with your biology:

• Reduce hunger signals at the source
• Increase natural satiety after eating
• Decrease food cravings and obsessive food thoughts
• Make portion control feel natural, not forced

This is why GLP-1 therapy produces results that calorie restriction alone cannot achieve.

The Revolution in Obesity Treatment:

Before GLP-1 Medications:

• Diet and exercise alone: 3-5% sustained weight loss
• Older medications: 3-7% weight loss
• Bariatric surgery: 15-30% weight loss
• Gap between medication and surgery

After GLP-1 Medications:

• Semaglutide: 10-15% weight loss
• Tirzepatide: 15-22% weight loss
• Bridge the gap with non-surgical option
• Results rival some bariatric procedures

GLP-1 therapy has fundamentally changed what’s possible with medical weight loss treatment.

Understanding the best weight loss medications helps you see how GLP-1s compare to all available options.

How GLP-1 Therapy Works for Weight Loss

GLP-1 medications produce weight loss through multiple coordinated mechanisms affecting hunger, digestion, metabolism, and brain signaling.

Mechanism 1: Brain Appetite Regulation

Where It Works: GLP-1 receptors exist throughout your brain, particularly in the hypothalamus—your brain’s appetite control center.

What Happens:

• GLP-1 medications cross the blood-brain barrier
• Activate receptors in appetite control regions
• Reduce hunger signals
• Increase satiety (feeling of fullness)
• Decrease reward response to food
• Reduce obsessive thoughts about food

What You Experience:

• Less frequent hunger
• Feel satisfied with smaller portions
• Don’t think about food constantly
• Reduced cravings for specific foods
• Easier to say no to unnecessary eating

This is the primary mechanism—you naturally eat less because you genuinely want less food.

Mechanism 2: Slowed Gastric Emptying

Where It Works: GLP-1 receptors in your stomach and intestines.

What Happens:

• Food stays in your stomach longer
• Slower movement from stomach to intestines
• Extended digestion time
• Prolonged feeling of fullness after eating

What You Experience:

• Stay full for 3-4 hours after meals instead of 1-2 hours
• Don’t need to snack between meals
• Smaller portions satisfy you
• Physical sensation of fullness lasts longer

Some people describe it as feeling like they ate a large meal even when they only ate a small amount.

Mechanism 3: Blood Sugar Regulation

Where It Works: GLP-1 receptors in your pancreas and liver.

What Happens:

• Increases insulin secretion when blood sugar rises
• Improves how effectively your cells respond to insulin
• Decreases glucagon (hormone that raises blood sugar)
• Reduces glucose production in liver

What You Experience:

• More stable blood sugar levels throughout day
• Fewer energy crashes
• Less reactive hunger from blood sugar drops
• Reduced cravings for sugary foods

Even if you don’t have diabetes, better blood sugar control reduces hunger and makes weight loss easier.

Mechanism 4: Metabolic Improvements

Where It Works: Throughout your body’s metabolic systems.

What Happens:

• Improved insulin sensitivity
• Better fat metabolism
• Reduced inflammation
• Positive effects on lipid profiles
• Lower blood pressure
• Cardiovascular benefits

What You Experience:

• More energy
• Better exercise tolerance
• Improved lab markers (cholesterol, triglycerides)
• Reduced risk of metabolic diseases

These effects contribute to overall health improvement beyond just weight loss.

How Tirzepatide’s Dual Mechanism Works:

GIP (Glucose-Dependent Insulinotropic Polypeptide) Adds:

Tirzepatide activates both GLP-1 and GIP receptors. The GIP component adds:

Enhanced Insulin Response:

• Even stronger blood sugar control than GLP-1 alone
• Better insulin secretion timing
• Improved insulin sensitivity in tissues

Fat Metabolism Effects:

• GIP receptors exist in fat tissue
• May influence how body stores and uses fat
• Potentially increases fat burning

Synergistic Appetite Suppression:

• GIP and GLP-1 together produce greater appetite reduction
• More potent satiety signals
• Stronger overall effect

This explains why tirzepatide produces 5-7% more weight loss than semaglutide—the dual action is more powerful than GLP-1 alone.

Timeline of How GLP-1s Work:

Week 1-2:

• Medication reaches therapeutic levels
• Begin noticing reduced appetite
• Food sounds less appealing
• Easier to stop eating when satisfied

Week 3-4:

• Appetite suppression more pronounced
• Portions naturally smaller
• Less frequent eating
• First measurable weight loss (3-5 pounds)

Week 5-12:

• Steady appetite control
• Consistent portion reduction
• Weight loss accelerates (1-2 pounds weekly)
• Side effects typically improving

Month 4-6:

• Dose increases continue (if tolerating well)
• Sustained weight loss (10-15 pounds total)
• New eating habits feeling normal
• Significant results becoming visible

Month 7-12:

• Approaching or reaching maintenance dose
• Steady continued weight loss
• Total loss: 15-30 pounds depending on starting weight
• Metabolic improvements evident in lab work

Month 13-20:

• Maximum weight loss achieved
• Average 10-22% total body weight lost
• Maintenance phase begins
• Focus shifts to sustaining results

What GLP-1s DON’T Do:

Common Misconceptions:

They don’t:

• ✗ “Burn fat” directly like thermogenic supplements
• ✗ Block calorie absorption like fat blockers
• ✗ Speed up metabolism dramatically
• ✗ Work without you eating less (you eat less naturally)
• ✗ Cure obesity (stopping leads to weight regain)
• ✗ Eliminate need for healthy habits

They do:

• ✓ Make eating less feel natural and sustainable
• ✓ Reduce biological hunger signals
• ✓ Help you consume fewer calories without constant struggle
• ✓ Provide biological support for behavioral changes
• ✓ Treat obesity as the chronic condition it is

Why GLP-1s Succeed Where Other Approaches Fail:

The Biological Barrier:

When you lose weight through calorie restriction alone:

• Your body produces more hunger hormone (ghrelin)
• Satiety hormones (leptin, GLP-1) decrease
• Metabolism slows by 15-20%
• Cravings intensify
• Your body fights to regain weight

This is why 80-95% of people who lose weight through diet alone regain it.

GLP-1 Medications Break This Cycle:

• Override increased hunger signals
• Maintain satiety despite calorie deficit
• Blunt metabolic adaptation
• Reduce intensity of cravings
• Support sustained weight loss

This is biological support, not just willpower.

Combining GLP-1 with Lifestyle Changes:

GLP-1 Medications Work Best When Combined With:

Nutrition:

• High-protein meals (20-30g per meal)
• Plenty of vegetables and fiber
• Adequate hydration
• Avoiding trigger foods that worsen nausea

Physical Activity:

• Regular walking (30 minutes daily)
• Strength training (2-3x weekly to preserve muscle)
• Movement that you enjoy and will sustain
• Gradually increasing as weight decreases

Behavioral Changes:

• Mindful eating practices
• Stress management
• Adequate sleep (7-9 hours)
• Support system

GLP-1 medications make these changes easier by reducing hunger and cravings, but the lifestyle changes enhance results and improve overall health.

Realistic Expectations:

GLP-1 Therapy Is Not:

• A quick fix
• A substitute for healthy habits
• A cure for obesity
• Without side effects
• Effective for everyone

GLP-1 Therapy Is:

• The most effective weight loss medication available
• Biologically based treatment for chronic disease
• Effective when combined with lifestyle changes
• Generally well-tolerated despite common side effects
• Successful for 85-95% of patients who try it

Understanding how semaglutide compares to tirzepatide helps you choose which GLP-1 medication is right for you.

Available GLP-1 Medications: Complete Overview

Several GLP-1 and dual agonist medications are available, each with different dosing, effectiveness, and cost profiles.

Semaglutide (Wegovy, Ozempic):

Overview:

• Class: GLP-1 receptor agonist
• Administration: Once-weekly subcutaneous injection
• Average Weight Loss: 10-15% of body weight
• FDA Approval: Ozempic (2017), Wegovy (2021)

Available Doses:

• Starting: 0.25 mg weekly
• Escalation: 0.5 mg, 1.0 mg, 1.7 mg
• Maximum: 2.4 mg weekly for weight loss

Clinical Trial Results (STEP-1):

• Average weight loss: 14.9% over 68 weeks
• ≥5% weight loss: 86.4% of participants
• ≥10% weight loss: 69.1% of participants
• ≥15% weight loss: 50.5% of participants

Brand Options:

• Wegovy: FDA-approved for weight loss, $1,349/month
• Ozempic: FDA-approved for diabetes, prescribed off-label for weight loss, $969/month
• Compounded semaglutide: $199-$599/month, same active ingredient

Pros:

• Highly effective (10-15% weight loss)
• Proven cardiovascular benefits (20% reduction in heart attacks/strokes)
• Extensive safety data (on market since 2017)
• Once-weekly convenience
• Affordable compounded option available

Cons:

• Nausea in 44% of users (usually improves)
• Brand-name very expensive without insurance
• Periodic shortages affecting availability

Best For:

• Patients needing to lose 20-50 pounds
• Those with cardiovascular disease (proven benefits)
• Budget-conscious patients (compounded at $199/month)
• Anyone wanting highly effective, proven medication

Tirzepatide (Zepbound, Mounjaro):

Overview:

• Class: Dual GIP/GLP-1 receptor agonist
• Administration: Once-weekly subcutaneous injection
• Average Weight Loss: 15-22% of body weight
• FDA Approval: Mounjaro (2022), Zepbound (2023)

Available Doses:

• Starting: 2.5 mg weekly
• Escalation: 5 mg, 7.5 mg, 10 mg, 12.5 mg
• Maximum: 15 mg weekly for weight loss

Clinical Trial Results (SURMOUNT-1):

• Average weight loss: 22.5% over 72 weeks (15 mg dose)
• ≥5% weight loss: 96% of participants
• ≥10% weight loss: 89% of participants
• ≥15% weight loss: 78% of participants
• ≥20% weight loss: 63% of participants

Brand Options:

• Zepbound: FDA-approved for weight loss, $1,069/month
• Mounjaro: FDA-approved for diabetes, prescribed off-label for weight loss, $1,069/month
• Compounded tirzepatide: $349-$699/month, same active ingredient

Pros:

• Most effective weight loss medication available (15-22% loss)
• Lower nausea rates than semaglutide despite higher potency
• Best chance of achieving 20%+ weight loss
• Affordable compounded option available

Cons:

• More expensive than semaglutide (both brand and compounded)
• Newer medication (less long-term safety data than semaglutide)
• Cardiovascular outcomes trial still ongoing

Best For:

• Patients needing maximum weight loss (50+ pounds)
• Those who plateaued on semaglutide
• Anyone wanting most effective medication available
• Patients who can afford $349/month for compounded option

Liraglutide (Saxenda, Victoza):

Overview:

• Class: GLP-1 receptor agonist
• Administration: Daily subcutaneous injection
• Average Weight Loss: 5-8% of body weight
• FDA Approval: Victoza (2010), Saxenda (2014)

Available Dose:

• Escalate to 3.0 mg daily

Clinical Trial Results (SCALE):

• Average weight loss: 8.0% over 56 weeks
• Significantly less effective than newer GLP-1s

Cost:

• $1,400/month
• No compounded options available

Pros:

• Proven safety record (on market since 2010)

Cons:

• Daily injections (less convenient)
• Much less effective than semaglutide or tirzepatide
• More expensive than more effective options
• Largely obsolete now that better options exist

Verdict: Rarely prescribed anymore. Semaglutide and tirzepatide have largely replaced liraglutide due to superior effectiveness and once-weekly dosing.

Other GLP-1 Medications:

Dulaglutide (Trulicity):

• Once-weekly GLP-1 agonist
• FDA-approved for diabetes only
• Not typically prescribed for weight loss
• Modest weight loss (3-5 kg average)

Exenatide (Byetta, Bydureon):

• Older GLP-1 agonist
• Daily or weekly depending on formulation
• Less effective than newer options
• Rarely used now

Oral Semaglutide (Rybelsus):

• Daily tablet form of semaglutide
• Much less effective than injectable (3-5% weight loss)
• Strict dosing requirements (empty stomach, wait 30 minutes)
• Not recommended for weight loss

Side-by-Side Comparison:

Feature	Semaglutide	Tirzepatide	Liraglutide
Dosing	Weekly	Weekly	Daily
Weight Loss	10-15%	15-22%	5-8%
Nausea Rate	44%	30-37%	25%
Brand Cost	$1,349/mo	$1,069/mo	$1,400/mo
Compounded Cost	$199-$599	$349-$699	Not available
Time on Market	8 years	3 years	15 years
CV Benefits	Proven	Being studied	None proven
Effectiveness Rank	#2	#1	#3

Which GLP-1 Should You Choose?

Choose Tirzepatide If:

• Want maximum weight loss results
• Need to lose 50+ pounds
• Can afford $349/month (compounded)
• Want best medication available

Choose Semaglutide If:

• Want excellent results at lowest cost
• Need to lose 20-50 pounds
• Have cardiovascular disease
• Budget is primary concern ($199/month compounded)

Avoid Liraglutide:

• Daily injections inconvenient
• Much less effective than alternatives
• More expensive despite worse results
• No advantage over semaglutide or tirzepatide

Compounded vs Brand-Name:

Same Effectiveness:

• Identical active ingredient
• Same weight loss results
• Same side effects
• Same administration

Different:

• Cost: 67-85% cheaper
• Availability: Better supply
• Insurance: Compounded rarely covered
• Format: May be vials vs pens

Who Qualifies for GLP-1 Treatment?

GLP-1 weight loss medications are approved for specific patient populations based on BMI and health conditions.

FDA-Approved Eligibility Criteria:

Primary Qualification (BMI-Based):

You qualify if:

• BMI ≥30 (obesity category), OR
• BMI ≥27 (overweight category) PLUS at least one weight-related health condition

BMI Reference Guide:

Height	BMI 27 Weight	BMI 30 Weight
5’0″	140 lbs	153 lbs
5’2″	150 lbs	164 lbs
5’4″	158 lbs	175 lbs
5’6″	167 lbs	186 lbs
5’8″	177 lbs	197 lbs
5’10”	186 lbs	209 lbs
6’0″	196 lbs	221 lbs
6’2″	206 lbs	233 lbs

Weight-Related Health Conditions (For BMI 27-29.9):

Qualifying conditions include:

• Type 2 diabetes or prediabetes
• Hypertension (high blood pressure)
• High cholesterol or dyslipidemia
• Obstructive sleep apnea
• Cardiovascular disease
• Polycystic ovary syndrome (PCOS)
• Non-alcoholic fatty liver disease
• Osteoarthritis exacerbated by weight

If you have BMI 27-29.9 with any of these conditions, you qualify.

Age Requirements:

FDA-Approved Ages:

• Semaglutide (Wegovy): Age 12 and older
• Tirzepatide (Zepbound): Age 18 and older
• Liraglutide (Saxenda): Age 12 and older

Adolescent Use:

• Increasingly prescribed for teens with obesity
• Requires pediatric endocrinologist oversight
• Family involvement in treatment plan
• Emphasis on lifestyle changes alongside medication

Absolute Contraindications (Cannot Use GLP-1s):

You CANNOT use GLP-1 medications if you have:

Personal or Family History of Medullary Thyroid Carcinoma (MTC):

• Animal studies showed thyroid tumors with GLP-1s
• Not confirmed in humans but black box warning exists
• Absolute contraindication due to potential risk

Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2):

• Genetic condition predisposing to certain tumors
• Increases MTC risk
• GLP-1s contraindicated

Pregnancy or Planning Pregnancy:

• Animal studies showed fetal harm
• Stop medication 2 months before trying to conceive
• Cannot use during pregnancy or breastfeeding

Previous Severe Allergic Reaction to GLP-1 Medications:

• Anaphylaxis or severe reaction to same class
• Risk of recurrence too high

Relative Contraindications (Use with Caution):

Discuss carefully with provider if you have:

History of Pancreatitis:

• GLP-1s may increase pancreatitis risk
• Prior pancreatitis is relative contraindication
• Some providers won’t prescribe, others use with close monitoring

Severe Gastroparesis:

• GLP-1s slow stomach emptying
• May worsen severe gastroparesis
• Mild gastroparesis may be okay with monitoring

History of Eating Disorders:

• Anorexia or bulimia history
• Medication-induced appetite suppression may trigger relapse
• Requires careful psychological screening

Severe Kidney Disease:

• Dehydration from nausea/vomiting can affect kidneys
• Close monitoring necessary
• May need dose adjustments

Active Gallbladder Disease:

• Rapid weight loss increases gallstone risk
• Existing gallbladder problems may worsen
• Monitor closely or address before starting

Diabetic Retinopathy:

• Rapid blood sugar improvement may temporarily worsen retinopathy
• Requires ophthalmology monitoring
• Not a contraindication but needs caution

Who Is a Good Candidate:

Ideal GLP-1 Patient:

• BMI ≥30 or BMI ≥27 with comorbidities
• Previous weight loss attempts unsuccessful
• No contraindications
• Realistic expectations
• Willing to commit to lifestyle changes
• Can afford treatment long-term
• Comfortable with weekly injections
• Motivated to improve health

Good Candidates Also Include:

Type 2 Diabetics:

• Benefit from blood sugar control plus weight loss
• May reduce other diabetes medications
• Cardiovascular benefits (semaglutide proven)

Cardiovascular Disease Patients:

• Semaglutide reduces heart attack/stroke risk
• Weight loss improves cardiovascular health
• Beneficial for prevention and treatment

Prediabetics:

• 60-70% reduction in diabetes progression
• Prevent full-blown diabetes
• Improve metabolic health

PCOS Patients:

• Weight loss improves PCOS symptoms
• Better insulin sensitivity
• May improve fertility

Who May Not Be Good Candidates:

Consider Alternatives If:

BMI <27 Without Comorbidities:

• Not FDA-approved indication
• Most providers won’t prescribe
• Focus on lifestyle modifications

Very Advanced Age:

• Frailty concerns
• Muscle loss risks with rapid weight loss
• Individual assessment needed

Active Cancer Treatment:

• Nausea from GLP-1s may compound chemotherapy side effects
• Weight loss may be detrimental during treatment
• Discuss with oncologist

Severe Psychiatric Conditions:

• Eating disorders (anorexia, bulimia)
• Active suicidal ideation
• Severe depression without treatment
• Psychiatric clearance may be needed

Financial Inability to Sustain Treatment:

• GLP-1s require long-term use
• Stopping leads to weight regain
• Must be able to afford medication for 18-24+ months
• Compounded options make this more accessible

Special Populations:

Pregnancy and Breastfeeding:

• Do not use during pregnancy
• Stop 2 months before trying to conceive
• Unknown if passes into breast milk
• Avoid during breastfeeding

Children and Adolescents:

• Wegovy approved age 12+
• Requires pediatric obesity specialist
• Family-based approach
• Growing evidence of safety and effectiveness

Elderly Patients:

• Can use with caution
• Monitor for muscle loss
• Ensure adequate protein intake
• More careful dose escalation

Bariatric Surgery Patients:

• Can use GLP-1s after surgery
• May help if weight regain occurs
• Enhances surgical results
• Increasingly common combination

Qualification Checklist:

Use this checklist to assess if you qualify:

• BMI ≥30, or BMI ≥27 with weight-related condition
• Age 18+ (12+ for some medications)
• No personal/family history of MTC or MEN 2
• Not pregnant or planning pregnancy soon
• No severe GLP-1 allergy history
• No active pancreatitis
• No severe eating disorder
• Can commit to long-term treatment
• Comfortable with weekly injections
• Have realistic expectations

If you checked all boxes, you likely qualify. Consult with a provider to confirm.

TrimRx providers can assess your eligibility during an online consultation and determine if GLP-1 therapy is appropriate for you.

Expected Results and Timeline

Understanding realistic outcomes and timeframes helps set appropriate expectations for GLP-1 therapy.

Average Weight Loss Results:

Semaglutide (Wegovy, Ozempic):

• Average: 10-15% of body weight lost
• Best case: 15-20% of body weight lost
• Minimum responders: 5-10% of body weight lost
• Timeline: 68 weeks (16 months) to maximum

Tirzepatide (Zepbound, Mounjaro):

• Average: 15-22% of body weight lost
• Best case: 25-30% of body weight lost
• Minimum responders: 10-15% of body weight lost
• Timeline: 72 weeks (18 months) to maximum

Real-World Examples:

200-Pound Person:

Starting Weight	Medication	Average Loss	Final Weight
200 lbs	Semaglutide	30 lbs (15%)	170 lbs
200 lbs	Tirzepatide	40 lbs (20%)	160 lbs

250-Pound Person:

Starting Weight	Medication	Average Loss	Final Weight
250 lbs	Semaglutide	37 lbs (15%)	213 lbs
250 lbs	Tirzepatide	50 lbs (20%)	200 lbs

300-Pound Person:

Starting Weight	Medication	Average Loss	Final Weight
300 lbs	Semaglutide	45 lbs (15%)	255 lbs
300 lbs	Tirzepatide	60 lbs (20%)	240 lbs

Month-by-Month Timeline:

Months 1-2: Getting Started

What Happens:

• Start at lowest dose (0.25 mg semaglutide or 2.5 mg tirzepatide)
• Body adjusts to medication
• Appetite begins decreasing
• Side effects most noticeable

Expected Weight Loss:

• 3-5 pounds
• Mostly water weight initially
• Some fat loss beginning

What to Expect:

• Reduced hunger between meals
• Smaller portions satisfying
• Some nausea or GI discomfort
• Learning injection technique

Months 3-4: Momentum Builds

What Happens:

• Dose increases to 0.5 mg semaglutide or 5 mg tirzepatide
• Appetite suppression more pronounced
• Side effects typically improving
• Weight loss accelerating

Expected Weight Loss:

• 8-12 pounds total (5-7 pounds these 2 months)
• 1-2 pounds per week
• Visible changes beginning

What to Expect:

• Consistent appetite control
• Easier to stick to healthy eating
• More energy as weight decreases
• Clothes fitting differently

Months 5-6: Steady Progress

What Happens:

• Dose increases to 1.0 mg semaglutide or 7.5 mg tirzepatide
• Sustained weight loss
• New habits forming
• Results becoming obvious

Expected Weight Loss:

• 15-20 pounds total (7-8 pounds these 2 months)
• 1.5-2 pounds per week
• 8-10% of starting weight lost

What to Expect:

• Significant visible changes
• Need smaller clothing sizes
• Improved energy and mobility
• Lab improvements (if checked)
• Family/friends noticing changes

Months 7-12: Continued Loss

What Happens:

• Dose increases to 1.7-2.4 mg semaglutide or 10-15 mg tirzepatide
• Approaching maintenance dose
• Weight loss continues steadily
• Metabolic benefits maximizing

Expected Weight Loss:

• 25-35 pounds total (10-15 pounds these 6 months)
• 1-1.5 pounds per week
• 12-17% of starting weight lost

What to Expect:

• Substantial transformation
• Multiple clothing sizes smaller
• Improved health markers
• Better physical function
• Sustained appetite control

Months 13-20: Reaching Maximum

What Happens:

• At maintenance dose
• Weight loss continuing but slower
• Approaching maximum loss
• Maintaining new weight becoming focus

Expected Weight Loss:

• 30-50+ pounds total (5-15 pounds these months)
• 0.5-1 pound per week
• 15-22% of starting weight lost (depending on medication)

What to Expect:

• Final weight stabilizing
• Focus on maintaining
• Lifestyle changes solidified
• Dramatic overall transformation

Factors Affecting Results:

Why Some People Lose More:

• Start at higher weight (more to lose)
• Strictly follow lifestyle recommendations
• Reach higher medication doses
• Excellent medication adherence
• Good side effect tolerance
• Genetic factors (responder status)

Why Some People Lose Less:

• Can’t tolerate higher doses due to side effects
• Inconsistent medication adherence
• Don’t implement lifestyle changes
• Have conditions affecting metabolism (hypothyroidism, PCOS)
• Genetic factors (lower responder)
• Medications interfering with weight loss

Individual Variation:

“Responder” Spectrum:

Super Responders (10-15% of patients):

• Lose 25-30% of body weight
• Excellent tolerance of maximum doses
• Dramatic appetite suppression
• May lose more than clinical trial averages

Average Responders (70-80% of patients):

• Lose 15-22% with tirzepatide, 10-15% with semaglutide
• Experience typical side effects
• Reach maintenance doses successfully
• Match clinical trial averages

Low Responders (10-15% of patients):

• Lose 5-10% of body weight
• May have significant side effects limiting doses
• Moderate appetite suppression
• Below clinical trial averages
• May benefit from switching medications or adding interventions

You can’t predict which category you’ll fall into until you try the medication.

Plateaus Are Normal:

What to Expect:

• Initial rapid loss (first 3 months)
• Continued steady loss (months 4-12)
• Plateau period (months 13-18)
• Final adjustments (months 19-24)

Plateaus don’t mean failure:

• Natural part of weight loss
• Body adjusting to new weight
• May need dose optimization
• Continue medication to maintain loss

Non-Scale Victories:

Results Beyond the Number:

Even if weight loss is slower than hoped, patients experience:

• Reduced waist circumference: Lost inches even when scale stalls
• Better blood pressure: 5-10 mmHg reduction common
• Improved blood sugar: A1C reductions of 1-2 points
• Better cholesterol: 10-20% improvement in lipids
• Increased energy: From weight loss and metabolic improvements
• Improved mobility: Easier movement, less joint pain
• Better sleep: Improvement in sleep apnea
• Enhanced quality of life: Confidence, mood, relationships

These improvements matter regardless of exact pounds lost.

When to Expect Specific Benefits:

Within Weeks:

• Reduced appetite and cravings
• Better blood sugar control (if diabetic)
• Initial energy improvements

Within Months:

• Visible weight loss (10+ pounds)
• Blood pressure improvements
• Better mobility and exercise tolerance
• Clothing size changes

Within 6-12 Months:

• Major weight loss (20-40 pounds)
• Significant health marker improvements
• Dramatic appearance changes
• Potential medication reductions (diabetes, BP meds)

Long-Term (12-24 Months):

• Maximum weight loss achieved
• Sustained health improvements
• Reduced risk of obesity complications
• Better overall quality of life

Setting Realistic Goals:

Healthy Goal-Setting:

Instead of “I want to lose X pounds by Y date,” focus on:

• Process goals: “Take medication consistently every week”
• Behavior goals: “Eat protein at every meal”
• Health goals: “Lower my A1C to non-diabetic range”
• Function goals: “Be able to walk 3 miles comfortably”

Weight goals should be:

• 10-15% of starting weight minimum (clinically significant)
• 15-25% of starting weight aspirational
• Flexible timelines (16-24 months)
• Focused on health improvements, not just numbers

Understanding how to buy semaglutide online safely ensures you get legitimate medication that produces these expected results.

Side Effects and Safety Information

GLP-1 medications are generally well-tolerated, but understanding potential side effects helps you prepare and manage them effectively.

Common Side Effects (Experienced by 20%+ of Patients):

Gastrointestinal Effects:

Nausea:

• Frequency: 30-44% depending on medication
• When: Most common during dose increases
• Duration: Usually peaks within 2-3 days of injection, improves by day 5-6
• Timeline: Most severe first 2 months, significantly better by month 3-4

Management:

• Eat smaller, frequent meals
• Avoid fatty, greasy, spicy foods
• Stay hydrated with clear fluids
• Ginger tea or ginger candies
• Inject before bed (sleep through worst nausea)
• Anti-nausea medication if severe (ondansetron, promethazine)

Diarrhea:

• Frequency: 19-30% of patients
• Usually mild to moderate
• Often improves after first month

Management:

• Increase fiber gradually
• Stay hydrated with electrolyte drinks
• Avoid trigger foods (dairy, caffeine, high-fat)
• Probiotics may help
• Anti-diarrheal medication if severe (loperamide)

Constipation:

• Frequency: 10-24% of patients
• Due to slowed GI transit

Management:

• Increase water intake (64-80 oz daily)
• Add fiber-rich foods
• Regular physical activity
• Stool softeners if needed (docusate)
• Magnesium supplements
• Miralax for occasional use

Vomiting:

• Frequency: 9-24% of patients
• Less common than nausea
• Usually during dose escalation

Management:

• Same strategies as nausea
• May need to slow dose escalation
• Contact provider if can’t keep fluids down

Abdominal Discomfort:

• Frequency: 8-20% of patients
• Usually mild bloating or cramping
• Related to slowed digestion

Management:

• Smaller portions
• Avoid gas-producing foods
• Gentle movement after meals
• Heat pad for comfort

Other Common Side Effects:

Fatigue:

• Frequency: 10-15% of patients
• Often related to reduced calorie intake

Management:

• Ensure adequate protein (80-100g daily)
• Don’t restrict calories too severely
• Regular sleep schedule
• Light exercise can boost energy

Headache:

• Frequency: 10-14% of patients
• Usually mild and temporary

Management:

• Stay hydrated
• OTC pain relievers (acetaminophen, ibuprofen)
• Usually resolves after first few weeks

Injection Site Reactions:

• Frequency: 5-10% of patients
• Mild redness, itching, or swelling

Management:

• Rotate injection sites
• Allow medication to reach room temperature before injecting
• Ice area before/after injection
• Usually resolves within days

Serious Side Effects (Rare but Important):

Pancreatitis:

• Risk: Less than 1% of patients
• Symptoms: Severe abdominal pain radiating to back, nausea, vomiting, fever
• Action: Stop medication immediately, seek emergency care
• Outcome: Usually resolves after discontinuation

Gallbladder Problems:

• Risk: 1-2% of patients
• Cause: Rapid weight loss increases gallstone risk
• Symptoms: Right upper abdominal pain, nausea, fever
• Action: Seek medical evaluation
• May require gallbladder removal in severe cases

Kidney Problems:

• Risk: Rare, usually from severe dehydration
• Symptoms: Decreased urination, swelling, confusion
• Prevention: Stay well-hydrated, especially during GI side effects
• Action: Contact provider if symptoms occur

Thyroid Tumors (Black Box Warning):

• Risk: Seen in animal studies, not confirmed in humans
• Absolute contraindication: Personal or family history of MTC or MEN 2
• Symptoms: Lump in neck, difficulty swallowing, persistent hoarseness
• Action: Report thyroid symptoms to provider immediately

Hypoglycemia (Low Blood Sugar):

• Risk: Low when GLP-1s used alone
• Higher risk: When combined with insulin or sulfonylureas
• Symptoms: Shakiness, sweating, confusion, dizziness, rapid heartbeat
• Prevention: Diabetes medication doses may need reduction
• Action: Treat with fast-acting carbs, contact provider about dose adjustments

Allergic Reactions:

• Risk: Very rare
• Symptoms: Difficulty breathing, facial swelling, severe rash, throat tightness
• Action: Seek emergency care immediately
• Contraindication for future use

Side Effect Timeline:

First Week:

• Mild nausea possible
• Reduced appetite begins
• GI changes starting
• Injection site learning curve

Weeks 2-4:

• Side effects may intensify
• Nausea peaks for many
• GI symptoms most noticeable
• Fatigue from calorie reduction

Weeks 5-8:

• Dose increase may temporarily worsen side effects
• But overall improvement from week 4
• Body adapting to medication
• Most patients feeling better

Weeks 9-12 and Beyond:

• Significant improvement in side effects
• GI symptoms mild or resolved
• Appetite suppression sustained
• Most patients tolerating well

For many patients, the worst side effects are weeks 2-6, with major improvement after 2 months.

Who Experiences More Side Effects:

Higher Risk of Side Effects:

• Women (higher rates than men)
• Starting at higher doses
• Rapid dose escalation
• History of GI issues (GERD, IBS)
• Slower metabolism
• Older age

Lower Risk of Side Effects:

• Men (lower rates than women)
• Gradual dose escalation
• Prior GLP-1 exposure
• Following dietary recommendations

Managing Side Effects Successfully:

Diet Modifications:

Foods to Emphasize:

• Lean proteins (chicken, fish, eggs)
• Non-starchy vegetables
• Clear broths and soups
• Crackers, toast (for nausea)
• Ginger (natural anti-nausea)
• Peppermint tea

Foods to Avoid:

• Fatty, greasy foods (worsen nausea)
• Spicy foods (irritate GI tract)
• Large portions (harder to digest)
• Carbonated drinks (increase bloating)
• Alcohol (worsens nausea, dehydration)
• High-sugar foods (blood sugar swings)

Eating Strategies:

• Small, frequent meals (5-6 times daily)
• Eat slowly, chew thoroughly
• Stop when satisfied (don’t push to full)
• Stay upright after eating (prevents reflux)
• Don’t drink large amounts with meals

When to Contact Your Provider:

Urgent (Call Immediately):

• Severe abdominal pain
• Persistent vomiting (can’t keep fluids down)
• Signs of dehydration (dark urine, dizziness, confusion)
• Severe allergic reaction
• Vision changes
• Symptoms of pancreatitis

Non-Urgent (Schedule Appointment):

• Side effects not improving after 4 weeks
• Want to discuss slowing dose escalation
• Questions about managing side effects
• Considering anti-nausea medication
• Weight loss plateau concerns

Discontinuation Rates:

Due to Side Effects:

• Semaglutide: 6.9% discontinue
• Tirzepatide: 6.2% discontinue
• Over 93% of patients tolerate well enough to continue

Long-Term Safety:

Semaglutide:

• On market since 2017 (8 years)
• Extensive real-world safety data
• SELECT trial: Actually reduced cardiovascular events (20% reduction)
• No new safety concerns with longer use

Tirzepatide:

• On market since 2022 (3 years)
• Growing real-world safety data
• Clinical trials show excellent safety profile
• Cardiovascular outcomes trial ongoing

Both medications appear safe for long-term use based on available evidence.

Drug Interactions:

Medications Requiring Monitoring:

Insulin and Sulfonylureas:

• GLP-1s may increase hypoglycemia risk
• Dose reductions usually needed
• Close blood sugar monitoring

Blood Thinners (Warfarin):

• GLP-1s may affect warfarin levels
• Monitor INR more frequently initially

Oral Medications:

• Slowed stomach emptying may affect absorption
• Take important medications 1 hour before GLP-1 injection
• Discuss timing with provider

Generally Compatible With:

• Blood pressure medications
• Cholesterol medications
• Most psychiatric medications
• Thyroid medications

Pregnancy and Breastfeeding:

Pregnancy:

• Do not use GLP-1s during pregnancy
• Animal studies showed potential fetal harm
• Stop medication 2 months before trying to conceive
• Use reliable contraception during treatment

Breastfeeding:

• Unknown if GLP-1s pass into breast milk
• Avoid use during breastfeeding
• Discuss alternatives with provider

Bottom Line on Safety:

GLP-1 medications are:

• ✓ Generally well-tolerated (93% continue treatment)
• ✓ Side effects usually manageable and improve over time
• ✓ Serious side effects rare (<2%)
• ✓ Safe for long-term use based on current evidence
• ✓ Benefits typically outweigh side effects for appropriate patients

Keys to success:

• Start at lowest dose
• Escalate gradually
• Follow dietary recommendations
• Stay hydrated
• Communicate with provider about side effects
• Don’t suffer unnecessarily—management strategies help

Learn about affordable Mounjaro alternatives that provide the same medication with the same side effect profile at lower cost.

Cost and Insurance Coverage

Understanding the full cost picture helps you budget for GLP-1 therapy and explore all available options.

Brand-Name Costs (Without Insurance):

Monthly List Prices:

• Wegovy (semaglutide): $1,349
• Ozempic (semaglutide): $969
• Zepbound (tirzepatide): $1,069
• Mounjaro (tirzepatide): $1,069
• Saxenda (liraglutide): $1,400

Annual Costs:

• Semaglutide: $11,628-$16,188/year
• Tirzepatide: $12,828/year
• For 18-month treatment: $17,442-$24,282

These prices are unsustainable for most cash-pay patients.

Insurance Coverage:

Coverage Likelihood:

Most Likely to Be Covered:

• Ozempic for type 2 diabetes (diabetes indication)
• Mounjaro for type 2 diabetes (diabetes indication)

Sometimes Covered:

• Wegovy for weight loss (if plan covers obesity treatment)
• Zepbound for weight loss (newer, fewer plans cover)

Rarely Covered:

• Weight loss medications on most plans
• Medicare/Medicaid don’t cover for weight loss (federal law)

Typical Copays (If Covered):

• Tier 2 (preferred): $25-$75/month
• Tier 3 (non-preferred): $100-$200/month
• Specialty tier: $200-$300/month or 25-33% coinsurance

Prior Authorization Requirements:

Insurance Typically Requires:

Documentation of:

• BMI ≥30 or BMI ≥27 with comorbidities (documented)
• Failed weight loss attempts (6-12 months documented diet/exercise)
• Medical necessity letter from provider
• No contraindications

May Also Require:

• Nutrition counseling documentation
• Exercise program participation
• Weight loss journal
• Commitment to lifestyle modifications
• Regular follow-up appointments

Timeline:

• Prior authorization: 1-4 weeks processing
• Appeals if denied: Additional 2-8 weeks
• No guarantee of approval

Manufacturer Savings Programs:

Eli Lilly (Mounjaro/Zepbound):

• Savings Card: May reduce cost to $25/month
• Requirements: Commercial insurance (not Medicare/Medicaid)
• Not available for: Uninsured cash-pay patients
• Income limits: May apply

Novo Nordisk (Wegovy/Ozempic):

• Savings Card: May reduce cost to $25/month
• Requirements: Commercial insurance (not Medicare/Medicaid)
• Not available for: Uninsured cash-pay patients

If you qualify for savings cards, brand-name medications become very affordable ($25-$50/month).

Compounded Medication Costs:

Monthly Pricing:

Semaglutide:

• TrimRx: $199/month with annual commitment
• Other providers: $199-$599/month
• Average: $300-$400/month

Tirzepatide:

• TrimRx: $349/month with annual commitment
• Other providers: $349-$699/month
• Average: $450-$550/month

What’s Included (TrimRx):

• Licensed provider consultation
• Prescription
• Medication from FDA-registered pharmacy
• All injection supplies (syringes, needles, alcohol pads, sharps container)
• Free shipping with cold-chain packaging
• Monthly follow-up appointments
• Access to medical support

Annual Costs:

• Semaglutide: $2,388-$7,188
• Tirzepatide: $4,188-$8,388

Insurance Coverage for Compounded:

• Insurance: Rarely covers compounded medications
• HSA/FSA: Usually eligible for compounded medications
• Payment: Out-of-pocket at time of service

Cost Comparison:

Option	Monthly	Annual (18 mo)	Total 18 Mo
Brand Semaglutide (no insurance)	$1,349	$16,188	$24,282
Brand Tirzepatide (no insurance)	$1,069	$12,828	$19,242
Brand (with savings card)	$25-$50	$300-$600	$450-$900
Brand (typical insurance)	$150-$250	$1,800-$3,000	$2,700-$4,500
Compounded Semaglutide (TrimRx)	$199	$2,388	$3,582
Compounded Tirzepatide (TrimRx)	$349	$4,188	$6,282

Hidden Costs to Consider:

Additional Expenses:

Medical Visits (If Not Included):

• Initial consultation: $150-$300
• Follow-up visits: $100-$200 each
• Required frequency: Monthly

Lab Work:

• Initial labs: $150-$300
• Periodic monitoring: $100-$200
• May be covered by insurance separately

Anti-Nausea Medication:

• If needed: $10-$50/month
• Usually temporary

Transportation:

• For in-person visits
• Parking fees
• Time off work

Telehealth Eliminates:

• Transportation costs
• Time off work
• Parking fees
• Often includes visits in monthly price

HSA/FSA Eligibility:

Can Use for:

• Compounded GLP-1 medications
• Brand-name medications (with prescription)
• Medical consultations
• Lab work
• Supplies

Tax Savings:

• Pre-tax dollars = 20-30% savings
• $199/month medication costs ~$140-$160 after tax benefit
• $349/month medication costs ~$245-$280 after tax benefit

Strategies to Reduce Costs:

1. Try Insurance First:

• If you have insurance, attempt approval
• Savings cards may reduce to $25/month
• Worth the effort if potential for low copay
• But don’t wait months if denied—move to alternatives

2. Use Compounded Medications:

• 67-85% cheaper than brand-name
• Same active ingredient and effectiveness
• TrimRx offers lowest pricing with full support

3. Choose Annual Commitments:

• Many providers discount for longer commitments
• TrimRx pricing based on annual commitment
• Saves 15-30% vs month-to-month

4. Use HSA/FSA Funds:

• Pre-tax savings of 20-30%
• Makes monthly cost more affordable
• Plan ahead to maximize HSA contributions

5. Start with Semaglutide:

• Lower cost than tirzepatide ($199 vs $349)
• Still highly effective (10-15% weight loss)
• Can upgrade to tirzepatide later if desired

6. Compare Multiple Providers:

• Pricing varies widely ($199-$699 for same medication)
• Check what’s included in price
• Verify pharmacy partners

Cost-Effectiveness Analysis:

Cost Per Pound Lost (18-Month Treatment):

Option	Total Cost	Pounds Lost	Cost/Pound
Compounded Semaglutide	$3,582	37	$97
Compounded Tirzepatide	$6,282	56	$112
Brand Semaglutide (no ins)	$24,282	37	$656
Brand Tirzepatide (no ins)	$19,242	56	$344

Compounded medications offer 6-7x better cost-effectiveness than brand-name for cash-pay patients.

Long-Term Budget Planning:

Plan For:

Active Weight Loss (18-24 months):

• Semaglutide: $3,582-$4,776
• Tirzepatide: $6,282-$8,376

Maintenance Phase (Indefinite):

• Same monthly cost continues
• May reduce to lower maintenance dose
• Budget for long-term treatment

Total 3-Year Cost:

• Semaglutide: $7,164
• Tirzepatide: $12,564

Financial Assistance:

If You Can’t Afford Treatment:

Options to Explore:

1. Patient assistance programs (brand-name manufacturers)
2. Community health centers (may offer reduced-cost programs)
3. Clinical trials (free medication, but specific requirements)
4. Flexible spending accounts (plan ahead for next year)
5. Medical credit cards (CareCredit, etc. – use cautiously)

Making Treatment Sustainable:

Key Questions:

• Can I afford this for 18-24 months minimum?
• What happens if I need to stop due to cost?
• Is there a lower-cost option that still works?
• Can I use pre-tax dollars to reduce cost?

Weight regain after stopping makes long-term affordability crucial.

Bottom Line on Cost:

For Cash-Pay Patients:

• Best value: Compounded semaglutide at $199/month
• Maximum results: Compounded tirzepatide at $349/month
• Avoid: Brand-name at $1,000+/month (unsustainable)

With Good Insurance:

• Try savings cards: May get $25/month brand-name
• If high copays: Compounded may be cheaper
• Factor in: Total out-of-pocket including deductibles

Plan for long-term treatment costs—obesity is a chronic condition requiring sustained therapy.

Getting Started with GLP-1 Therapy

Ready to begin? Here’s your step-by-step guide to starting GLP-1 treatment safely and effectively.

Step 1: Determine Your Eligibility

Quick Self-Assessment:

Calculate Your BMI: BMI = (Weight in pounds / (Height in inches)²) × 703

Or use this quick reference:

• 5’4″, 175 lbs = BMI 30
• 5’6″, 186 lbs = BMI 30
• 5’8″, 197 lbs = BMI 30
• 5’10”, 209 lbs = BMI 30

You likely qualify if:

• ✓ BMI ≥30, OR
• ✓ BMI 27-29.9 + diabetes, hypertension, high cholesterol, or sleep apnea
• ✓ Age 18+ (12+ for some medications)
• ✓ No personal/family history of thyroid cancer
• ✓ Not pregnant or planning pregnancy

If you meet these criteria, proceed to Step 2.

Step 2: Choose Your Approach

Option A: Through Insurance

Best for: People with insurance that might cover

Process:

1. Check if your plan covers Wegovy or Zepbound
2. Contact insurance about requirements
3. See in-network provider
4. Complete prior authorization
5. If approved with low copay, use insurance
6. If denied or copay too high, consider Option B

Timeline: 2-8 weeks Cost if successful: $25-$300/month

Option B: Compounded Through Telehealth

Best for: Cash-pay patients, high insurance copays, want immediate access

Process:

1. Choose reputable provider (TrimRx)
2. Complete online consultation
3. Get prescription same day if approved
4. Medication ships in 3-7 days
5. Start treatment

Timeline: 3-7 days total Cost: $199-$349/month

Most people find Option B faster, easier, and more affordable.

Step 3: Complete Medical Consultation

Information You’ll Provide:

Medical History:

• Current height and weight
• Medical conditions (diabetes, hypertension, thyroid issues, etc.)
• Current medications and supplements
• Allergies
• Family history (especially thyroid cancer)
• Previous weight loss attempts
• Surgical history

Current Health:

• Recent blood pressure
• Latest lab work (if available)
• Current symptoms
• Pregnancy status

Lifestyle:

• Diet patterns
• Exercise habits
• Stress levels
• Sleep quality
• Support system

Be completely honest—accurate information ensures safe prescribing.

Consultation Format:

Asynchronous (Most Common):

• Complete detailed questionnaire online
• Provider reviews within 24-48 hours
• Responds with questions or approval
• Can message with questions

Live Video/Phone:

• Scheduled appointment (15-30 minutes)
• Real-time discussion with provider
• Ask questions directly
• Decision made during visit

What Provider Assesses:

• Eligibility for GLP-1 therapy
• Which medication is best for you
• Starting dose
• Contraindications
• Realistic expectations
• Commitment to treatment

Step 4: Choose Your Medication

Decision Framework:

Choose Semaglutide If:

• Want excellent results at lowest cost
• Need to lose 20-50 pounds
• Budget is primary concern ($199/month)
• Have cardiovascular disease

Choose Tirzepatide If:

• Want maximum results
• Need to lose 50+ pounds
• Can afford $349/month
• Want most effective medication

Your provider will help you decide based on your goals, health status, and budget.

Step 5: Receive Your Medication

What Arrives:

Package Contents:

• Medication vials or syringes
• Syringes and needles (if using vials)
• Alcohol prep pads
• Sharps container for safe needle disposal
• Instruction guide
• Storage information

Immediate Actions:

1. Verify package arrived cold (ice packs present)
2. Check medication appearance (should be clear, colorless)
3. Confirm expiration/beyond-use date
4. Store in refrigerator immediately (36-46°F)
5. Don’t freeze
6. Keep in original packaging

Step 6: Prepare for First Injection

Before Your First Dose:

Watch Training Video:

• Most providers supply injection tutorials
• See technique demonstrated
• Learn proper steps
• Review safety measures

Gather Supplies:

• Medication from refrigerator (can sit at room temp 15-30 min)
• Syringe and needle (if using vial)
• Alcohol prep pad
• Sharps container
• Cotton ball or gauze (optional)

Choose Injection Site:

• Abdomen (2+ inches from belly button)
• Front/side of thigh
• Back of upper arm (may need help)
• Rotate sites each week

Step 7: Administer First Injection

Injection Steps:

1. Wash hands thoroughly with soap and water
2. Prepare injection site
   • Clean with alcohol pad
   • Let air dry (don’t blow on it)
3. Prepare medication
   • If using vial: Draw prescribed dose into syringe
   • If using pre-filled syringe: Remove cap
   • Check for air bubbles, tap syringe to remove
4. Pinch skin gently between thumb and fingers
5. Insert needle at 90-degree angle
   • Quick, dart-like motion
   • Needle should go fully under skin
6. Inject medication
   • Push plunger slowly and steadily
   • Hold for 5 seconds after injecting
7. Remove needle
   • Pull straight out
   • Release pinched skin
   • Apply gentle pressure if needed
8. Dispose of needle
   • Place directly into sharps container
   • Never recap needle

First Injection Tips:

• Take your time—no need to rush
• Most people find it much easier than expected
• Needle is very small and thin
• Quick insertion hurts less than slow
• Contact provider support if you need help

Step 8: Manage First Week

What to Expect:

Days 1-2:

• May not notice much initially
• Medication building up in system
• Continue eating normally

Days 3-5:

• Appetite may start decreasing
• Food might sound less appealing
• Some mild nausea possible

Days 6-7:

• Reduced hunger more noticeable
• Smaller portions satisfying
• First pounds of weight loss (water weight)

Managing Early Side Effects:

For Nausea:

• Eat smaller, frequent meals
• Choose bland, easy-to-digest foods
• Avoid fatty and spicy foods
• Ginger tea helps
• Stay hydrated

For Fatigue:

• Don’t restrict calories too much
• Ensure adequate protein
• Get regular sleep
• Light activity helps

For GI Upset:

• Increase fiber gradually
• Stay hydrated
• Avoid trigger foods
• Usually improves within weeks

Step 9: Establish Your Routine

Weekly Injection Schedule:

Pick Same Day Each Week:

• Choose a day that works for your schedule
• Many prefer Sunday evening (forget about it all week)
• Set phone reminder
• Can inject same day ±2 days if needed

Create Routine:

1. Set medication out 30 minutes early (room temp comfort)
2. Prepare injection area
3. Inject at same general time
4. Track in calendar or app
5. Note any side effects

Lifestyle Practices:

Nutrition:

• Prioritize protein (20-30g per meal)
• Eat vegetables with every meal
• Stay hydrated (64+ oz water daily)
• Avoid drinking calories
• Listen to hunger cues

Physical Activity:

• Start with daily walking (30 minutes)
• Add strength training 2-3x/week
• Preserve muscle during weight loss
• Gradually increase as weight decreases

Tracking:

• Weekly weigh-ins (same day, same time)
• Measurements (waist, hips)
• Progress photos (monthly)
• How you feel (energy, mobility)
• Non-scale victories

Step 10: Attend Follow-Up Appointments

Typical Schedule:

Week 2:

• Check in on side effects
• Review injection technique
• Answer questions
• Assess initial tolerance

Month 1:

• First dose increase (if tolerating well)
• Review weight loss progress
• Adjust management strategies
• Prescription refill

Monthly Thereafter:

• Continue dose escalation
• Monitor progress toward goals
• Manage any issues
• Optimize treatment

Between Appointments:

• Message provider with questions
• Report concerning side effects
• Request help if struggling
• Update on any health changes

Troubleshooting Common Early Issues:

“I’m Not Losing Weight Yet”

• Normal in first 2-3 weeks
• Takes time to reach therapeutic levels
• Weight loss accelerates as dose increases
• Be patient

“The Nausea Is Really Bad”

• Contact provider about anti-nausea medication
• May slow down dose escalation
• Try dietary modifications
• Usually improves significantly by week 6-8

“I Forgot My Injection”

• Take as soon as you remember if within 5 days
• If more than 5 days late, skip and take next dose on schedule
• Don’t double up
• Set reminders to prevent forgetting

“I Don’t Like Injections”

• Use numbing cream before injection (topical lidocaine)
• Inject slowly to reduce discomfort
• Distract yourself during injection
• Gets easier with practice
• Most people adjust within 2-3 weeks

Success Tips:

For Best Results:

• ✓ Take medication consistently every week
• ✓ Follow dietary recommendations
• ✓ Stay physically active
• ✓ Attend all follow-up appointments
• ✓ Communicate openly with provider
• ✓ Be patient with timeline (16-20 months)
• ✓ Focus on non-scale victories too
• ✓ Commit to long-term treatment

Avoid:

• ✗ Skipping doses
• ✗ Ignoring side effects that persist
• ✗ Expecting rapid results (takes time)
• ✗ Relying solely on medication (combine with lifestyle)
• ✗ Stopping too soon
• ✗ Comparing your results to others

When to Contact Provider:

Urgent:

• Severe abdominal pain
• Can’t keep fluids down
• Signs of allergic reaction
• Vision changes
• Severe side effects

Non-Urgent but Important:

• Side effects not improving after 4 weeks
• Questions about dose escalation
• Weight loss concerns
• Need anti-nausea medication
• General questions about treatment

Ready to Start?

TrimRx makes starting GLP-1 therapy simple:

1. Complete online health assessment (10 minutes)
2. Consult with licensed provider (24-48 hours)
3. Medication ships to your door (3-7 days)
4. Begin your weight loss journey with full support

Choose your medication:

• Compounded Semaglutide: $199/month
• Compounded Tirzepatide: $349/month

Both include licensed medical consultations, all supplies, free shipping, and ongoing support.

Frequently Asked Questions

What exactly is GLP-1 therapy for weight loss? GLP-1 therapy uses medications that mimic a natural hormone your body produces to regulate appetite and blood sugar. These medications (semaglutide and tirzepatide) are injected once weekly and produce 10-22% average body weight loss by reducing hunger, increasing feelings of fullness, and slowing digestion. GLP-1 therapy is the most effective weight loss medication treatment available, producing results previously only achievable through bariatric surgery.

How much weight can you lose with GLP-1 medications? With semaglutide (Wegovy, Ozempic), patients lose an average of 10-15% of body weight (25-37 pounds for a 250-pound person) over 16-18 months. With tirzepatide (Zepbound, Mounjaro), patients lose an average of 15-22% of body weight (37-55 pounds for a 250-pound person) over 18-20 months. Individual results vary, but 85-95% of patients lose at least 5% of their body weight.

Do GLP-1 medications require injections? Yes, the most effective GLP-1 medications (semaglutide and tirzepatide) are once-weekly subcutaneous injections using very small, thin needles. The injections are much easier than most people expect—similar to a quick pinch. An oral form of semaglutide (Rybelsus) exists but is significantly less effective (3-5% weight loss vs 10-15% with injections). Most patients find weekly injections preferable to daily pills.

What are the most common side effects of GLP-1 therapy? The most common side effects are gastrointestinal: nausea (30-44%), diarrhea (19-30%), constipation (10-24%), and occasional vomiting (9-24%). These side effects are usually most noticeable during the first 2 months and improve significantly by weeks 6-8. Most patients (93%) tolerate side effects well enough to continue treatment. Strategies like eating smaller meals, avoiding fatty foods, and taking anti-nausea medication help manage symptoms.

How much does GLP-1 weight loss therapy cost? Brand-name medications cost $969-$1,349/month without insurance. With insurance coverage and savings cards, copays may be $25-$300/month. Compounded GLP-1 medications cost significantly less: semaglutide averages $199-$599/month (TrimRx: $199/month), and tirzepatide averages $349-$699/month (TrimRx: $349/month). Compounded options provide the same active ingredient at 67-85% lower cost.

Do you have to stay on GLP-1 medications forever? Most patients need long-term or indefinite treatment to maintain weight loss. Clinical trials show that stopping GLP-1 medications leads to weight regain for most people—patients regained 2/3 of lost weight within one year of stopping. Obesity is a chronic condition, and GLP-1 medications treat the underlying biology. Think of it like blood pressure or diabetes medication—ongoing treatment manages a chronic condition rather than curing it.

Can I get GLP-1 medications through telehealth? Yes, licensed telehealth providers can prescribe GLP-1 medications after appropriate medical evaluation. TrimRx offers complete online service including consultations with licensed providers, prescriptions, and medication delivery to your door—all without requiring in-person visits. This makes GLP-1 therapy accessible regardless of your location or ability to visit weight loss clinics in person.

Which is better: semaglutide or tirzepatide? Tirzepatide produces superior weight loss (15-22% vs 10-15% with semaglutide) due to its dual GIP/GLP-1 mechanism. However, semaglutide costs less (compounded: $199 vs $349/month), has proven cardiovascular benefits, and longer safety track record. Choose tirzepatide for maximum weight loss or semaglutide for excellent results at lower cost. Compare both medications in detail.

Who should not take GLP-1 medications? GLP-1 medications are contraindicated for people with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). They should not be used during pregnancy or breastfeeding. Use caution if you have history of pancreatitis, severe gastroparesis, or eating disorders. Consult a provider to determine if GLP-1 therapy is safe for your specific situation.

How long does it take to see results with GLP-1 therapy? Most people notice reduced appetite within 1-2 weeks of starting. Measurable weight loss typically begins by weeks 3-4 (3-5 pounds). Significant weight loss becomes apparent by months 3-6 (15-25 pounds) and continues for 16-20 months until reaching maximum results. Weight loss is gradual and sustained rather than rapid—expect to lose 1-2 pounds per week on average once therapeutic doses are reached.

Ready to begin your GLP-1 weight loss journey? TrimRx provides accessible, affordable access to compounded semaglutide at $199/month and compounded tirzepatide at $349/month with licensed medical oversight, FDA-registered pharmacy partners, and complete support.