Mastering Your Ozempic Pen: A Guide to Safe and Effective Injections

Reading time
50 min
Published on
December 16, 2025
Updated on
December 16, 2025
Mastering Your Ozempic Pen: A Guide to Safe and Effective Injections

Introduction

Embarking on a journey toward improved health often involves embracing new routines and learning specific techniques. For many, this includes managing medications delivered through injection pens, which can initially feel daunting. Yet, with the right guidance and a clear understanding, this process can become a simple, empowering part of your weekly regimen. Ozempic, a medication frequently prescribed for managing type 2 diabetes and supporting cardiovascular health, is administered via a pre-filled pen, and knowing precisely how to use it is fundamental to its effectiveness and your safety.

Here at TrimRx, we understand that true wellness extends beyond a prescription; it encompasses comprehensive support, clear instruction, and a deep sense of confidence. Our journey began with a shared vision: to help individuals embrace healthier lifestyles by merging cutting-edge telehealth innovations with effective weight loss solutions. We believe sustainable weight loss should be achieved through science, empathy, and a transparent approach, creating a user-friendly and supportive space where individuals receive personalized, medically supervised care. This guide is crafted with that very philosophy in mind, aiming to demystify the Ozempic pen injection process and empower you with the knowledge needed to administer your medication safely and effectively.

In this comprehensive guide, we will walk you through every step of using your Ozempic pen, from initial preparation and crucial safety checks to the precise injection technique and proper disposal. We’ll delve into the nuances of dose selection, discuss optimal injection sites, and share vital storage recommendations, ensuring you feel completely confident with each weekly dose. By the end of this article, you will not only understand the mechanics of your Ozempic pen but also appreciate the broader context of how this medication, alongside personalized support from TrimRx, can be a cornerstone of your health journey. Our goal is to equip you with the insights to take control of your treatment, transforming a potentially complex task into a routine you can manage with ease.

Understanding Ozempic: More Than Just a Medication

Ozempic is a globally recognized medication, and understanding its role and how it functions is the first step in appreciating the importance of proper administration. For individuals managing type 2 diabetes, Ozempic often represents a significant tool in their treatment plan.

What is Ozempic?

Ozempic is a brand name for semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist. It is FDA-approved to improve blood sugar control in adults with type 2 diabetes, used in conjunction with diet and exercise. Beyond its primary role in glycemic management, Ozempic is also indicated to lower the risk of major cardiovascular events, such as heart attack or stroke, in adults with type 2 diabetes and established heart disease. This dual benefit highlights its significance in comprehensive health management.

While Ozempic itself is specifically approved for type 2 diabetes, the active ingredient, semaglutide, is also approved under a different brand name (Wegovy®) for chronic weight management in adults with obesity or overweight with at least one weight-related condition. Similarly, another GLP-1 and GIP receptor agonist, tirzepatide, is approved under brand names like Mounjaro® for type 2 diabetes and Zepbound® for weight management. These advancements have revolutionized how we approach metabolic health, offering powerful tools for both blood sugar control and weight loss.

The TrimRx Approach to Personalized Care

At TrimRx, we recognize that every individual’s health journey is unique, which is why our platform offers personalized, medically supervised care tailored to your specific needs. Our comprehensive programs go beyond simply prescribing medication; we provide a supportive ecosystem designed to make sustainable weight loss attainable and integrated with your overall health goals. We believe in empowering you with choices that align with your health profile and lifestyle. This includes access to various prescription options like Compounded Semaglutide, Oral Semaglutide, Ozempic®, Compounded Tirzepatide, Oral Tirzepatide, Mounjaro®, Zepbound®, and Wegovy®.

To begin exploring your options and determine eligibility for these prescription weight loss medications, we encourage you to take our free assessment quiz. This quiz helps us understand your unique health needs and allows our licensed medical professionals to craft a personalized treatment plan that is right for you. Our commitment to transparent service means our approach remains consistent, and our focus on safety is paramount, working exclusively with FDA-registered and inspected pharmacies for the shipping of all medications. With TrimRx, you’re not just getting medication; you’re gaining a partner dedicated to your long-term success through a scientifically-backed, empathetic, and trustworthy approach.

Preparing for Your Injection: The Foundation of Safety

Proper preparation is the cornerstone of a safe and effective injection. Before you even touch your Ozempic pen, a few critical steps ensure that your medication is ready and that you minimize any risks associated with the injection process.

Gathering Your Essential Supplies

Before you begin, assemble everything you will need in one clean, well-lit area. This helps ensure a smooth, uninterrupted process and prevents you from having to search for items mid-preparation. Your essential supplies include:

  • Your Ozempic Pen: The pre-filled, multi-dose pen that contains your medication.
  • A New NovoFine Plus or NovoFine Needle: These are specific needles designed for Ozempic pens. Always ensure you have a fresh, unused needle for each injection.
  • An Alcohol Swab: For cleaning the injection site to reduce the risk of infection.
  • Gauze or a Cotton Ball: To apply gentle pressure to the injection site after administering the medication, if needed.
  • An FDA-Cleared Sharps Disposal Container or Heavy-Duty Plastic Household Container: This is crucial for the immediate and safe disposal of used needles.

Having all these items readily available streamlines the process and reinforces our commitment to providing you with the tools and knowledge for safe and effective self-care.

The Crucial Pre-Injection Check

Before attaching a needle or dialing a dose, take a moment to carefully inspect your Ozempic pen. This vital step helps confirm that your medication is viable and safe to use.

Verifying Medication Integrity

  1. Check the Pen Label: Confirm that the label on your Ozempic pen precisely matches the medication and dosage prescribed by your healthcare provider. This prevents accidental use of an incorrect medication or strength.
  2. Inspect the Liquid: Look at the medication inside the pen’s window. It should be clear and colorless, resembling water. If you notice any cloudiness, discoloration, or particles floating in the liquid, do not use the pen. These changes can indicate that the medication has been compromised, potentially affecting its efficacy and safety.
  3. Confirm Expiration Date: Locate the expiration date printed on the pen or its label. Never use medication that has expired, as its potency and safety cannot be guaranteed.

At TrimRx, our unwavering commitment to safety means we partner exclusively with FDA-registered and inspected pharmacies for the shipping of all weight loss medications. This rigorous standard ensures that the medications you receive are handled and prepared with the utmost care and quality control, aligning with our values of trustworthiness and transparency.

Attaching Your Needle Correctly

Once you’ve confirmed your pen is ready, it’s time to attach a new needle. This step is more than just a mechanical action; it’s a critical measure for preventing infection and ensuring accurate medication delivery.

The Step-by-Step Process for Needle Attachment:

  1. Select a New Needle: Always use a new, sterile needle for each injection. Reusing needles can lead to infection, blockage, and inaccurate dosing.
  2. Remove the Paper Tab: Peel off the protective paper tab from the new needle.
  3. Push and Turn: Carefully push the needle straight onto the pen and turn it until it is tight and securely attached.
  4. Remove the Outer Needle Cap: Gently pull off the outer cap from the needle and set it aside. You will need this to safely remove the needle after injection, but not to recap the needle directly.
  5. Remove the Inner Needle Cap: Carefully pull off the inner cap and immediately discard it in a suitable waste container (not necessarily a sharps container at this point, but ensure it’s not reused or left lying around).

The Unwavering Rule: Do Not Share

It is absolutely imperative that you never share your Ozempic pen or needles with anyone else, even if the needle has been changed. Sharing can transmit serious infections and is a significant health risk. This steadfast rule underscores our dedication to your individual health and safety within our personalized programs.

The “Flow Check”: Ensuring Medication Readiness

For every new Ozempic pen you start, there’s a vital preliminary step known as the “flow check.” This isn’t just a suggestion; it’s a critical procedure to ensure your pen is functioning correctly and that medication will flow properly during your first injection. Skipping this step could result in an incomplete dose, impacting the effectiveness of your treatment.

When and Why to Perform a Flow Check

The flow check needs to be performed only before the first injection with each new Ozempic pen. You do not need to repeat it for subsequent injections from the same pen. The purpose of this check is twofold:

  1. To Confirm Needle Patency: It verifies that the needle is not blocked and that there is a clear pathway for the medication to exit the pen.
  2. To Prime the Pen: It ensures that any air in the needle or pen is expelled, so you receive a full, accurate dose of medication.

This meticulous attention to detail is part of the rigorous, medically supervised care that TrimRx champions. We understand that precision in medication administration is key to achieving results in your weight loss journey and overall health management.

Step-by-Step Flow Check

Follow these instructions carefully to perform a successful flow check:

  1. Turn to the Flow Check Symbol: Locate the dose selector on your Ozempic pen. Turn it until the flow check symbol (often a small line or dot indicator, as depicted in the pen’s instructions for use) aligns with the dose pointer.
  2. Press and Hold the Dose Button: With the needle pointing upwards, press and hold the dose button until the dose counter shows “0.” It’s important that the “0” lines up precisely with the dose pointer.
  3. Verify the Drop: Observe the tip of the needle. A small drop of Ozempic should appear. This visible drop confirms that the pen is primed and ready for use.
  4. Troubleshooting:
    • If no drop appears: If you don’t see a drop, repeat the flow check procedure up to six times.
    • If still no drop: If after repeating the flow check six times, a drop of Ozempic still does not appear, change the needle and repeat the flow check one more time with the new needle.
    • Do Not Use the Pen: If a drop of Ozempic still does not appear after changing the needle and repeating the flow check, do not use the pen. Contact your healthcare provider or the manufacturer for guidance. Do not attempt to force the medication or use a faulty pen, as this could compromise your dosage and safety.

This detailed checking process is part of the careful consideration that goes into your personalized weight loss program. When you partner with TrimRx, you gain access to comprehensive support that ensures you are confident and informed about every aspect of your treatment, including proper medication handling.

Selecting Your Prescribed Dose: Precision is Key

Administering the correct dose of Ozempic is paramount to the safety and effectiveness of your treatment. Your healthcare provider carefully determines your dosage based on your individual health needs and treatment plan. Adhering strictly to these instructions is a critical component of your journey toward better health and weight management.

Dialing in Accuracy

Once your pen has passed the flow check (if it’s a new pen), the next step is to select your prescribed dose:

  1. Locate the Dose Selector: Identify the dose selector at the end of your Ozempic pen.
  2. Turn the Selector: Carefully turn the dose selector until the dose counter displays the exact milligram (mg) amount prescribed by your doctor. The numbers on the dose counter should align perfectly with the dose pointer. You will often feel clicks as you turn the selector, confirming each increment.
  3. Verify the Dose: Double-check the number in the dose counter to ensure it matches your prescribed dose.

What to Do If There Isn’t Enough Medication

It is possible that as you near the end of a pen, there might not be enough Ozempic left for a full dose. If you turn the dose selector and it stops before your prescribed dose appears in the dose counter, this indicates there isn’t sufficient medication remaining in that pen. In such a scenario, do not attempt to inject a partial dose or try to combine doses from two pens. Instead:

  • Use a New Ozempic Pen: You must use a new Ozempic pen to ensure you receive your complete, accurate dose.

This precision in dosing aligns perfectly with the results-oriented and personalized approach we champion at TrimRx. We understand that consistent, accurate medication administration is fundamental to achieving your health goals.

Understanding Your Dosage Plan

Your journey with Ozempic or other GLP-1 and GIP receptor agonists like compounded semaglutide, oral semaglutide, Mounjaro®, Zepbound®, or Wegovy® is highly individualized. The dosage prescribed is part of a carefully considered treatment plan developed by licensed medical professionals. These plans often involve starting at a lower dose and gradually increasing it over time, allowing your body to adjust and minimizing potential side effects.

At TrimRx, our personalized weight loss programs emphasize this tailored approach. Through our comprehensive service, which includes doctor consultations and lab work, we ensure that your treatment plan, including medication dosage, is optimized for your unique physiology and health objectives. We also offer unlimited support to address any questions or concerns you may have about your medication or its administration.

If you are exploring options for personalized weight loss that include prescription medications, we invite you to take our free assessment quiz. This crucial first step helps determine your eligibility and allows our team to create a comprehensive, medically supervised plan designed just for you, ensuring safe and effective progress.

The Injection Process: Confidence in Every Step

Administering your Ozempic injection, once you’ve mastered the preparation and dose selection, becomes a straightforward routine. The key is to approach it with confidence, knowing you have thoroughly prepared and understand each action. This section guides you through choosing an injection site, the injection technique itself, and important post-injection care.

Choosing the Right Injection Site

Selecting and preparing your injection site is a vital part of ensuring comfort and efficacy. Ozempic is designed for subcutaneous injection, meaning it is injected just under the skin, not into a muscle or vein.

Recommended Areas for Injection:

You have several suitable areas on your body for subcutaneous injection:

  • Abdomen: The most common site. Choose an area on your stomach, ideally at least two inches away from your belly button.
  • Thigh: The front of your thighs is another appropriate site.
  • Upper Arm: The outer area of your upper arm can also be used.

The Critical Practice of Rotating Injection Sites:

It is crucial to change (rotate) your injection site with each injection. This doesn’t necessarily mean switching between your stomach, thigh, and arm every week, but rather using a different spot within the chosen area. For example, if you inject into your abdomen one week, choose a slightly different spot on your abdomen the next week. Rotation helps prevent lipohypertrophy (a thickening of the skin that can occur from repeated injections in the same spot), reduces discomfort, and ensures consistent medication absorption.

Cleaning the Site:

Before injecting, clean the chosen area of skin with an alcohol swab. Allow the skin to air dry completely. This simple step significantly reduces the risk of infection. Do not touch the cleaned area before injecting.

Executing the Injection

With your site prepared and your dose selected, you’re ready to inject. This is where precision and a steady hand come into play, ensuring the medication is delivered correctly.

  1. Insert the Needle: Gently but firmly insert the needle straight into the cleaned skin. Ensure you can still see the dose counter on your pen.
  2. Press and Hold the Dose Button: With the needle inserted, press and hold down the dose button firmly. You might hear or feel a click as the injection begins.
  3. Watch the Dose Counter: Continue holding the dose button down. Observe the dose counter as it slowly moves back to “0.” This confirms that the medication is being delivered.
  4. The Slow Count to Six: Once the dose counter shows “0,” keep the needle in your skin and continue holding the dose button down, slowly counting to six. This critical step ensures that the entire dose has been fully delivered and prevents medication leakage when you remove the needle.
  5. Remove the Needle and Pen: After counting to six, carefully remove the needle straight out of your skin and release the dose button.

We understand that performing injections can feel like a significant step, and our empathetic approach at TrimRx means we are here to support you. Our commitment to unlimited support ensures that any questions or anxieties you have about the injection process can be addressed by our dedicated team, empowering you with the confidence you need.

Post-Injection Care and Considerations

Once the injection is complete, a few final steps ensure your comfort and continued safety:

  • Apply Pressure if Needed: If you experience any slight bleeding or a small drop of blood at the injection site, gently press a clean cotton ball or gauze over the area for a few seconds until any bleeding stops. Do not rub the site vigorously.
  • Observe for Reactions: While rare, observe the injection site for any unusual reactions like severe redness, swelling, or pain. If you have any concerns, contact your healthcare provider.
  • Consistency is Key: Remember that Ozempic is a once-weekly injection. Establishing a consistent day and time for your injection each week can help you stay on track with your treatment plan.

Our comprehensive service at TrimRx is designed to support you at every stage, from initial consultation to ongoing medication management and wellness guidance. We believe in providing transparent, compassionate care, ensuring you have all the resources needed to navigate your journey successfully. Beyond prescription medications, we also offer quick-access supplements like our GLP-1 Daily Support and Weight Loss Boost, which can complement your overall health and weight loss efforts.

Safe Disposal and Proper Storage: Protecting Your Health and Medication

The journey with your Ozempic pen doesn’t end with the injection itself. Proper disposal of used needles and correct storage of your medication are equally critical for your safety, the efficacy of the drug, and public health. These practices align with our foundational values of safety and responsible care at TrimRx.

The Importance of Correct Needle Disposal

Used needles are biohazardous waste and must be handled and disposed of with extreme caution to prevent accidental needle sticks, injuries, and the spread of infections.

Using a Sharps Disposal Container:

  1. Immediate Disposal: Immediately after removing the needle from your skin, place it directly into an FDA-cleared sharps disposal container. These containers are specifically designed to safely hold used needles and other sharp medical waste.
  2. Alternative Container: If an FDA-cleared sharps container is not immediately available, you can use a heavy-duty plastic household container, such as an empty laundry detergent bottle or a hard plastic opaque bottle with a screw-on cap. Ensure this container is puncture-resistant, leak-proof, and clearly labeled “Sharps” or “Hazardous Waste.”
  3. Never Recap Needles: Under no circumstances should you attempt to recap or bend a used needle. Recapping significantly increases the risk of an accidental needle stick injury.
  4. Proper Container Fullness: Do not overfill your sharps container. When it is about three-quarters full, it’s time to dispose of it properly. Regulations for sharps disposal vary by state and local community, so it’s important to consult your local waste management services or healthcare provider for specific guidance on how to dispose of a full sharps container.

Proper disposal isn’t just a recommendation; it’s a responsibility that contributes to a safer environment for everyone. Our comprehensive support at TrimRx extends to providing guidance on such essential practices, reinforcing our commitment to your well-being beyond your immediate treatment.

Optimizing Medication Storage for Efficacy

Storing your Ozempic pens correctly ensures that the medication maintains its potency and effectiveness throughout its shelf life. Improper storage can degrade the medication, rendering it less effective or even unsafe.

Storage Guidelines:

  1. New, Unused Pens: Store new, unused Ozempic pens in the refrigerator at a temperature between 36°F to 46°F (2°C to 8°C). Keeping them refrigerated helps preserve the medication’s integrity until you are ready to use them.
  2. Pen in Use: Once you start using a pen, you have flexibility with its storage. You can keep the pen either at room temperature, between 59°F to 86°F (15°C to 30°C), or continue to store it in the refrigerator (36°F to 46°F / 2°C to 8°C).
  3. Discard After 8 Weeks: Regardless of whether you store it at room temperature or in the refrigerator, an Ozempic pen in use should be thrown away after 8 weeks, even if there is still medication left in it. This eight-week period ensures the medication remains stable and effective.
  4. Do Not Freeze: It is absolutely crucial never to freeze Ozempic. If Ozempic has been frozen, do not use it, as freezing can damage the medication and alter its effectiveness.
  5. Protection from Elements: Always keep your Ozempic pens away from direct heat and out of direct sunlight. Exposure to extreme temperatures or light can compromise the medication.
  6. Child Safety: Like all medications, Ozempic pens should be kept out of the reach and sight of children and pets.

Adhering to these storage guidelines is a simple yet powerful way to ensure your medication works as intended, supporting your journey towards improved health outcomes. At TrimRx, we equip you with comprehensive knowledge and supportive resources, making sure you have all the information needed to manage your personalized weight loss program effectively and safely.

Beyond the Pen: Holistic Support for Your Weight Loss Journey with TrimRx

Understanding how to use your Ozempic pen effectively is a crucial part of your health journey, but at TrimRx, we believe true transformation comes from a holistic, supportive, and deeply personalized approach. Our platform is designed to be your unwavering partner, offering far more than just medication. We integrate advanced medical science with modern technology, providing compassionate care that respects every individual’s unique path.

Comprehensive Care and Resources

Our commitment to your well-being extends across every facet of your experience. We pride ourselves on offering a comprehensive service that encompasses all the essential components for a successful and sustainable weight loss journey:

  • Doctor Consultations: You receive personalized consultations with licensed medical professionals who understand your health history and tailor a treatment plan specifically for you. This medically supervised approach ensures your care is both safe and effective.
  • Medication Access: For those eligible, we provide access to a range of clinically proven weight loss medications, including options like Compounded Semaglutide, Oral Semaglutide, Ozempic®, Compounded Tirzepatide, Oral Tirzepatide, Mounjaro®, Zepbound®, and Wegovy®. We partner exclusively with FDA-registered and inspected pharmacies to ensure your medications are safely and reliably dispensed.
  • Lab Work: To fully understand your health profile and monitor your progress, our programs include necessary lab work, ensuring your treatment plan is always optimized and responsive to your body’s needs.
  • Unlimited Support: Our empathetic and supportive brand personality shines through our commitment to unlimited support. Whether you have questions about your medication, need guidance on lifestyle adjustments, or simply require encouragement, our team is here for you every step of the way.
  • Shipping: We manage the secure and timely shipping of your medications directly from our partner pharmacies, providing convenience and peace of mind.
  • No Hidden Fees: We believe in complete transparency. Our comprehensive service ensures you understand exactly what your program includes, with no hidden fees, upholding our trustworthy approach.

This integrated approach is fundamental to our brand story, which began with a vision to help individuals embrace healthier lifestyles by merging cutting-edge telehealth innovations with effective weight loss solutions. Our platform is a user-friendly and supportive space where you receive personalized, medically supervised care, all designed to make sustainable weight loss attainable and tailored to you.

Supporting Your Progress with Quick-Access Supplements

While prescription medications form a cornerstone for many, we also understand the value of immediate, accessible support for overall wellness during your weight loss journey. To complement your personalized program or to provide beneficial support right away, we offer a range of quick-access supplements that do not require a quiz or prescription:

  • GLP-1 Daily Support: This supplement is designed to support overall wellness and complement the effects of GLP-1 receptor agonists, helping you feel your best as you progress. Explore the benefits of our GLP-1 Daily Support.
  • Weight Loss Boost: For those looking for immediate support to kickstart or enhance their weight loss efforts, our Weight Loss Boost is formulated to assist your body’s natural processes. Discover how our Weight Loss Boost can provide that extra push.

These supplements reflect our innovative spirit, offering valuable tools to support your journey, whether you’re embarking on a prescription program or seeking immediate wellness enhancements.

Your Next Step Towards a Healthier You

At TrimRx, we are more than a provider; we are a partner in your health. Our results-oriented programs are built on science, empathy, and a clear path to success. If you’re ready to explore a personalized, medically supervised weight loss solution tailored to your unique needs, we encourage you to take the first step.

Ready to see if you qualify for a personalized treatment plan featuring prescription weight loss medications? Take our free assessment quiz today. It’s a simple, no-obligation way to unlock your potential for sustainable health and well-being.

Conclusion

The journey to effective health management, particularly when it involves medications like Ozempic, is a testament to your commitment to well-being. By diligently following each step – from careful preparation and precise dose selection to confident injection and responsible disposal – you gain not only control over your medication but also a profound sense of empowerment over your health. This detailed guide on how to use your Ozempic pen is designed to strip away any apprehension, replacing it with knowledge and assurance.

At TrimRx, we stand by you on this path. Our foundation is built on merging cutting-edge telehealth innovations with effective, personalized weight loss solutions, always with an emphasis on safety, efficacy, and individualized care. We’ve highlighted how our brand values – empathetic, innovative, trustworthy, supportive, results-oriented, and personalized – are woven into every aspect of our service, from doctor consultations and medication access through FDA-registered pharmacies to unlimited support and a transparent approach to your care.

We believe that understanding and mastering your medication is a crucial part of achieving sustainable health outcomes. As you integrate these practices into your routine, remember that you’re not alone. Our comprehensive approach, including prescription medications like Ozempic (where appropriate), and complementary quick-access supplements like GLP-1 Daily Support and Weight Loss Boost, provides a robust framework for your success.

We encourage you to continue engaging with our resources and support system. If you’re ready to take the next step towards a personalized weight loss journey supported by medical expertise and compassionate care, we invite you to take our free assessment quiz. Let TrimRx be your guide to achieving your health goals with confidence and lasting results.

Frequently Asked Questions (FAQs)

Q1: How often should I use my Ozempic pen?

Ozempic is typically administered once a week. It’s important to choose a consistent day of the week that works best for your schedule and try to inject it around the same time each week. Always follow the specific dosing schedule prescribed by your healthcare provider.

Q2: What should I do if I miss a dose of Ozempic?

If you miss a dose of Ozempic, administer it as soon as you remember, within 5 days of the missed dose. If more than 5 days have passed since the missed dose, skip that dose and take your next dose on your regularly scheduled day. Do not take two doses within a 48-hour period. Always consult your healthcare provider or our TrimRx support team if you have questions about a missed dose.

Q3: Can I use the same needle for multiple injections?

No, you must always use a new, sterile needle for each injection. Reusing needles can lead to serious risks such as infection, blocked needles, and inaccurate dosing. Always dispose of used needles immediately and safely in an FDA-cleared sharps container.

Q4: How does TrimRx support me in managing my Ozempic treatment?

TrimRx offers a comprehensive, medically supervised weight loss program that includes doctor consultations, lab work, and access to medications like Ozempic for eligible individuals. We provide unlimited support to answer your questions about medication administration, side effects, and overall progress, ensuring a personalized and empathetic care experience. To get started and see if a personalized plan is right for you, take our free assessment quiz.

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