Metformin and Ozempic Together: Your Guide to Combined Weight Management and Diabetes Care

Introduction

For countless individuals, the journey toward managing Type 2 diabetes and achieving sustainable weight loss presents a complex landscape, often requiring a multifaceted approach. With nearly 40 million Americans living with diabetes and millions more grappling with weight-related health challenges, the quest for effective and personalized treatment is more pressing than ever. It’s a journey that can feel overwhelming, filled with questions about medication choices, potential combinations, and the best path forward for individual health. Two medications, Metformin and Ozempic, have emerged as powerful tools in this fight, each offering distinct benefits in blood sugar regulation and, for many, supporting weight loss. As treatment options evolve, the question naturally arises: should you take Metformin and Ozempic in conjunction with each other?

This detailed exploration aims to shed light on this crucial topic, providing clarity on how these two prominent medications work, their individual strengths, and the compelling reasons why they are increasingly prescribed together. We will delve into their unique mechanisms of action, the synergistic benefits of a combined approach, potential side effects, and the paramount importance of medical supervision. Our goal is to empower you with the knowledge needed to engage in informed conversations with your healthcare provider, understanding the nuances of such a powerful combination therapy. At TrimRx, our journey began with a shared vision to help individuals embrace healthier lifestyles by merging cutting-edge telehealth innovations with effective weight loss solutions. We believe that sustainable weight loss should be achieved through science, empathy, and a transparent approach, and this guide reflects that commitment to informed, personalized care. By the end of this post, you will have a comprehensive understanding of what to consider when exploring the combined use of Metformin and Ozempic for your health and weight loss goals, all within the supportive framework of a personalized, medically-guided program.

Understanding Metformin: A Foundational Pillar in Diabetes Management

Metformin stands as a cornerstone in the treatment of Type 2 diabetes, often being the first-line medication prescribed upon diagnosis. Its long-standing presence in the medical community and extensive research underscore its efficacy and safety profile. For decades, it has been a reliable ally in managing blood glucose levels, but its benefits extend beyond simple sugar control, touching upon various aspects of metabolic health.

How Metformin Works

Metformin belongs to a class of drugs called biguanides, and its primary mechanism of action is multifaceted. Unlike some other diabetes medications that directly stimulate insulin production, Metformin primarily focuses on improving the body’s response to insulin and reducing glucose output.

Reducing Hepatic Glucose Production

One of Metformin’s key roles is to decrease the amount of glucose (sugar) produced by the liver. In individuals with Type 2 diabetes, the liver can produce excessive glucose, contributing to high blood sugar levels. Metformin works by suppressing this process, primarily through activating an enzyme called AMP-activated protein kinase (AMPK), which plays a crucial role in cellular energy homeostasis. This reduction in glucose output from the liver is a significant factor in lowering fasting blood sugar levels.

Enhancing Insulin Sensitivity

Another vital action of Metformin is to improve the body’s sensitivity to insulin. Insulin resistance, where the body’s cells don’t respond effectively to insulin, is a hallmark of Type 2 diabetes. Metformin helps muscle and fat cells become more responsive to insulin, allowing them to absorb glucose from the bloodstream more efficiently. This means the body can utilize its own insulin more effectively, leading to better blood sugar control.

Modulating Glucose Absorption and Appetite

Metformin also has a subtle effect on the gastrointestinal tract, reducing the absorption of glucose from the food we eat. While this is a minor contributor to its overall glucose-lowering effect, it adds to its comprehensive action. Additionally, many individuals report a decrease in appetite or changes in cravings while taking Metformin, which can contribute to modest weight loss, a beneficial outcome for many managing Type 2 diabetes.

Broader Benefits Beyond Blood Sugar Control

While primarily known for its role in diabetes, research continues to unveil a spectrum of additional benefits associated with Metformin use. It has been shown to have positive effects on cardiovascular health, potentially reducing the risk of heart disease in individuals with Type 2 diabetes. Some studies even suggest potential neuroprotective effects, and its impact on the gut microbiome is an area of ongoing research, hinting at deeper metabolic advantages. The relatively affordable cost and generic availability make Metformin an accessible and widely utilized treatment option, often fully covered by most insurance plans.

Understanding Metformin’s Side Effects and Risks

Like all medications, Metformin comes with potential side effects, though many individuals tolerate it well.

Common Gastrointestinal Issues

The most frequently reported side effects are gastrointestinal in nature, including diarrhea, nausea, vomiting, flatulence, and abdominal discomfort. These symptoms often subside as the body adjusts to the medication, and taking Metformin with meals, particularly the evening meal, can significantly reduce their severity. Starting with a lower dose and gradually increasing it under medical supervision is a common strategy to improve tolerance.

Serious, Though Rare, Risks

A serious, albeit rare, risk associated with Metformin is lactic acidosis. This condition involves a buildup of lactic acid in the bloodstream and can be life-threatening. The risk is higher in individuals with kidney impairment, liver disease, heart failure, or those who consume excessive alcohol. Therefore, it’s crucial for healthcare providers to assess kidney function before and during Metformin treatment.

Other Considerations

Long-term use of Metformin may lead to a vitamin B12 deficiency in some individuals, necessitating regular monitoring and potential supplementation. Metformin is not suitable for individuals with Type 1 diabetes or certain types of metabolic acidosis.

For those considering Metformin as part of their health regimen, it’s vital to discuss your complete medical history with your healthcare provider to ensure it’s the right choice for you. Our commitment at TrimRx is to ensure that you receive medically supervised care tailored to your unique needs, whether that includes medications like Metformin or other personalized solutions.

Introducing Ozempic (Semaglutide): A Modern Evolution in Management

Ozempic, a brand name for the active ingredient semaglutide, represents a significant advancement in the treatment of Type 2 diabetes. As a glucagon-like peptide-1 (GLP-1) receptor agonist, Ozempic leverages the body’s natural physiological pathways to achieve robust blood sugar control and offers notable benefits, including cardiovascular protection and support for weight management.

The Mechanism of Action of Ozempic

Ozempic works by mimicking the effects of GLP-1, a hormone naturally produced in the gut in response to food intake. This mimicry leads to several powerful effects on glucose regulation and satiety.

Glucose-Dependent Insulin Secretion

One of the unique aspects of Ozempic is its ability to stimulate insulin secretion from the pancreas in a glucose-dependent manner. This means it only prompts insulin release when blood sugar levels are elevated, thereby reducing the risk of hypoglycemia (low blood sugar), which can be a concern with some other diabetes medications.

Suppression of Glucagon Secretion

Ozempic also helps to lower blood sugar by reducing glucagon secretion. Glucagon is a hormone that signals the liver to release stored glucose. By suppressing glucagon, Ozempic helps to further decrease hepatic glucose production, complementing Metformin’s action.

Slowed Gastric Emptying and Enhanced Satiety

A crucial effect of Ozempic is its impact on the digestive system. It slows down gastric emptying, meaning food remains in the stomach for a longer period. This contributes to a feeling of fullness (satiety) and can reduce overall food intake, which is a significant factor in the weight loss observed with Ozempic. The prolonged feeling of fullness can help manage cravings and reduce calorie consumption, making it a valuable tool in weight management strategies for individuals with Type 2 diabetes and those struggling with overweight or obesity.

FDA-Approved Indications and Weight Management Potential

Ozempic is FDA-approved for the treatment of Type 2 diabetes in adults to improve blood sugar control. Furthermore, it holds an additional FDA approval for reducing the risk of major cardiovascular events, such as heart attack and stroke, in adults with Type 2 diabetes and established cardiovascular disease. While Ozempic itself is primarily indicated for diabetes, its active ingredient, semaglutide, is also available in a higher dose formulation (Wegovy®) that is FDA-approved specifically for chronic weight management. Many individuals prescribed Ozempic for Type 2 diabetes also experience significant weight loss as an additional benefit.

Administration and Our Personalized Offerings

Ozempic is administered as a convenient once-weekly subcutaneous injection using a pre-filled pen. This once-a-week dosing schedule can significantly enhance adherence and convenience for many individuals compared to daily medications.

At TrimRx, we understand that access to these innovative treatments is paramount. Through our personalized weight loss program, we offer various options for prescription medications, including branded Ozempic® and Wegovy®, as well as high-quality compounded Semaglutide and Oral Semaglutide. To explore if these options are suitable for you and receive a tailored treatment plan, we invite you to take our free assessment quiz. This quiz is the first step towards personalized care, connecting you with licensed medical professionals who can determine your eligibility and guide you through your weight loss journey.

Potential Side Effects and Warnings with Ozempic

While highly effective, Ozempic also carries potential side effects, mainly gastrointestinal in nature.

Common Side Effects

The most common side effects include nausea, vomiting, diarrhea, constipation, and abdominal pain. These often improve over time as the body adjusts to the medication. Injection site reactions, such as redness, pain, or swelling, can also occur but are usually mild.

Serious Risks and Black Box Warning

Ozempic carries a “black box warning,” the most serious warning from the FDA, regarding the risk of thyroid C-cell tumors. Animal studies have shown that semaglutide can cause these tumors, though it’s unknown if it causes them in humans. Therefore, Ozempic is generally not prescribed to individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2). Patients should be vigilant for symptoms like a lump in the neck, hoarseness, or difficulty swallowing.

Other serious, though less common, risks include pancreatitis, gallbladder problems (e.g., gallstones), acute kidney injury, and vision changes in those with diabetic retinopathy. It is not approved for use in individuals with Type 1 diabetes.

When considering Ozempic or any GLP-1 medication, a thorough discussion with a healthcare provider is essential to assess individual risks and benefits. Our commitment to transparent service means we highlight these considerations, ensuring our approach remains consistent, and we prioritize your safety by working exclusively with FDA-registered and inspected pharmacies for the shipping of weight loss medications.

The Power of Combination: Why Metformin and Ozempic Work Together

Given the individual strengths of Metformin and Ozempic, it’s natural to question should you take Metformin and Ozempic together. For many individuals battling Type 2 diabetes and striving for weight loss, the answer, under careful medical supervision, is a resounding yes. These two medications, despite their different mechanisms, offer a highly complementary and synergistic approach to managing metabolic health.

Synergistic Mechanisms for Enhanced Control

Think of Metformin and Ozempic as two different but equally important tools in a well-equipped toolbox, each tackling the challenge of blood sugar regulation and weight management from a unique angle.

Addressing Insulin Resistance and Secretion Simultaneously

Metformin primarily works by improving the body’s insulin sensitivity and reducing glucose production by the liver. It makes the existing insulin more effective. Ozempic, on the other hand, stimulates insulin release when blood sugar is high and slows digestion. When combined, they provide a dual attack: Metformin helps the body use insulin better, and Ozempic ensures insulin is secreted appropriately while also managing post-meal glucose spikes and promoting satiety. This combined action often leads to more robust and sustained improvements in A1C levels and overall blood glucose control than either medication alone.

Amplified Weight Management Benefits

Both Metformin and Ozempic have demonstrated benefits for weight loss, albeit through different pathways. Metformin can lead to modest weight reduction by influencing appetite and reducing fat storage, particularly visceral fat. Ozempic, with its powerful effects on satiety and delayed gastric emptying, often results in more significant weight loss. When these medications are taken together, their individual weight-reducing effects can be additive, potentially leading to greater overall weight loss for many individuals. This enhanced weight management can, in turn, further improve insulin sensitivity and metabolic health.

Holistic Metabolic Improvement

The combination extends its benefits beyond just blood sugar and weight. Ozempic offers significant cardiovascular and kidney protective effects, which are crucial for individuals with Type 2 diabetes who are at increased risk for these complications. Metformin also contributes to cardiovascular health and has been associated with other broader metabolic advantages. By combining them, individuals can benefit from a more comprehensive improvement in their metabolic profile, addressing multiple facets of health simultaneously.

The Importance of Staggered Introduction

While combining Metformin and Ozempic can be highly beneficial, healthcare providers often recommend introducing them at different times. This “staggered” approach allows the body to adjust to each medication individually, making it easier to identify and manage any potential side effects. For instance, if significant gastrointestinal upset occurs, it’s simpler to pinpoint which medication is causing the issue if only one has been recently introduced or adjusted.

Our Commitment to Personalized, Medically Supervised Care

Deciding should you take Metformin and Ozempic together is a highly personal decision that must be made in consultation with a qualified healthcare professional. At TrimRx, we emphasize that personalized care is at the heart of our mission. Our platform connects you with licensed medical professionals who provide personalized medical supervision, ensuring that your treatment plan is specifically designed for your unique biology, health history, and goals. We believe that compassionate care respects every individual’s unique journey by combining advanced medical science with modern technology. Our comprehensive service includes doctor consultations, necessary lab work, medication, unlimited support from our team, and convenient shipping—all with no hidden fees, giving you full transparency and peace of mind.

Navigating Side Effects and Risks in Combination Therapy

When considering the question, should you take Metformin and Ozempic together, it’s crucial to understand how their combined use might influence potential side effects and overall safety. While generally safe and effective when prescribed together, a comprehensive understanding of what to expect is paramount for patient well-being.

Managing Gastrointestinal Side Effects

Both Metformin and Ozempic are known for their gastrointestinal side effects. Metformin commonly causes diarrhea, nausea, and stomach discomfort, while Ozempic can lead to nausea, vomiting, diarrhea, and constipation. When these medications are combined, there is a possibility that these symptoms could be more pronounced or occur more frequently.

Strategies for Mitigation:

• Gradual Titration: Healthcare providers typically initiate both medications at lower doses and gradually increase them over several weeks. This allows the body to adapt and can significantly reduce the severity of GI side effects.
• Timing of Dosing: Taking Metformin with meals, especially with the evening meal, can often help alleviate stomach upset. Ozempic can be taken with or without meals, but consistent timing can also aid in tolerance.
• Dietary Adjustments: Limiting greasy, fatty, or highly sugary foods might help minimize discomfort while the body adjusts.
• Hydration: Staying well-hydrated is always important, especially if experiencing diarrhea or vomiting.

Open communication with your healthcare provider is key to managing these effects. They can offer advice, adjust dosages, or explore alternative strategies to ensure your comfort and adherence to the treatment plan.

Understanding Hypoglycemia Risk

Compared to insulin or sulfonylureas, both Metformin and Ozempic individually carry a lower risk of causing hypoglycemia (low blood sugar). Metformin works by improving insulin sensitivity and reducing liver glucose output, rather than directly stimulating high insulin release. Similarly, Ozempic stimulates insulin secretion only when blood glucose levels are high, making it less likely to cause a significant drop in sugar.

However, when combined, or when either is used with other diabetes medications (like insulin or sulfonylureas), the risk of hypoglycemia can increase. It is essential to monitor blood glucose levels regularly, especially when initiating or adjusting doses of either medication. Your healthcare provider will guide you on appropriate monitoring and how to recognize and treat low blood sugar.

Drug Interactions and Contraindications

When taking any combination of medications, it is vital to be aware of potential drug interactions and contraindications.

Metformin Interactions:

Some medications can affect Metformin’s efficacy or increase the risk of lactic acidosis. These include certain carbonic anhydrase inhibitors, cimetidine, and some iodine contrast agents used in medical imaging. Alcohol consumption should be limited or avoided while taking Metformin, as it can increase the risk of lactic acidosis.

Ozempic Interactions:

Ozempic can slow the absorption of orally administered medications due to delayed gastric emptying. Doses of other diabetes medications, particularly insulin and sulfonylureas, may need to be adjusted to prevent hypoglycemia.

Specific Contraindications:

As previously discussed, Metformin is contraindicated in severe kidney or liver impairment, and metabolic acidosis. Ozempic should not be used in individuals with a personal or family history of medullary thyroid carcinoma or MEN2, or a history of pancreatitis. Before starting any combination therapy, a thorough review of your medical history and current medications is crucial to identify any potential risks.

At TrimRx, our comprehensive service includes doctor consultations and lab work precisely to assess these risks and ensure that any prescribed medications are safe and appropriate for you. We are dedicated to your safety, partnering only with FDA-registered and inspected pharmacies for the shipping of weight loss medications. Our brand is built on being trustworthy and supportive, guiding you through every step of your journey.

The Personalized Approach to Weight Loss and Diabetes Management with TrimRx

Navigating the complexities of Type 2 diabetes and achieving sustainable weight loss requires more than just medication; it demands a personalized, empathetic, and scientifically-backed approach. This is precisely where TrimRx distinguishes itself, offering a comprehensive and supportive framework designed to make your health goals attainable. Our journey began with a shared vision to help individuals embrace healthier lifestyles by merging cutting-edge telehealth innovations with effective weight loss solutions, and this vision underpins every aspect of our program.

Our Story, Values, and Unwavering Commitment

At TrimRx, we understand that every individual’s journey is unique. We are driven by the belief that sustainable weight loss should be achieved through science, empathy, and a transparent approach. This philosophy guides our brand, which is empathetic, innovative, trustworthy, supportive, results-oriented, and personalized. We offer compassionate care that respects every individual’s unique journey by combining advanced medical science with modern technology. Our commitment to transparent service is unwavering, ensuring that our approach remains consistent regardless of dosage changes, and our focus on safety is paramount. We work exclusively with FDA-registered and inspected pharmacies for the shipping of weight loss medications, giving you peace of mind that your care is in trusted hands.

A Comprehensive Service Tailored for You

When you partner with TrimRx, you gain access to a truly comprehensive service that covers every facet of your weight loss and diabetes management journey. We believe in providing everything you need without hidden fees, embodying our transparent approach. Our service includes:

• Doctor Consultations: Connecting you with licensed medical professionals who provide personalized medical supervision, crafting a treatment plan tailored to your specific health profile and goals.
• Medication: Access to a range of clinically proven medications, if deemed appropriate by your medical provider.
• Lab Work: Essential diagnostic testing to monitor your health, assess eligibility, and track progress effectively.
• Unlimited Support: Ongoing guidance and encouragement from our dedicated team, ensuring you never feel alone on your path to better health.
• Shipping: Convenient delivery of medications directly to your door, facilitated by our partnerships with FDA-registered and inspected pharmacies.

We want to make it unequivocally clear that while our platform connects you with licensed medical professionals who provide personalized medical supervision, the pharmacies we partner with for the shipping of weight loss medications are FDA-registered and inspected but do not provide actual medical supervision themselves. Their role is to ensure safe and compliant dispensing of your prescription.

Our Diverse Product Offerings for Personalized Care

TrimRx offers a range of solutions to meet diverse needs, divided into two distinct categories:

1. Personalized Weight Loss Program (Requires a Free Assessment Quiz)

For individuals seeking prescription-strength solutions, our personalized program offers a selection of medications known for their effectiveness in weight management and blood sugar control. To ensure these treatments are right for you, we require a comprehensive assessment. These options include:

• Compounded Semaglutide: A highly effective GLP-1 medication, personalized and prepared by FDA-registered and inspected pharmacies.
• Oral Semaglutide: An innovative oral form of semaglutide, offering an alternative to injections.
• Ozempic®: The branded, FDA-approved injectable semaglutide for Type 2 diabetes and cardiovascular risk reduction.
• Compounded Tirzepatide: Another powerful GLP-1/GIP receptor agonist, personalized and prepared by FDA-registered and inspected pharmacies.
• Oral Tirzepatide: The oral version of tirzepatide, for those preferring a non-injectable option.
• Mounjaro®: The branded, FDA-approved injectable tirzepatide for Type 2 diabetes.
• Zepbound®: The branded, FDA-approved injectable tirzepatide specifically for chronic weight management.
• Wegovy®: The branded, FDA-approved injectable semaglutide specifically for chronic weight management.

We strongly encourage you to take our free assessment quiz to determine your eligibility and receive a personalized treatment plan from a licensed medical professional. This crucial first step ensures that your care is tailored, safe, and effective.

2. Quick-Access Supplements (No Quiz Required)

In addition to our prescription programs, we offer immediate support supplements designed to complement your wellness journey and support overall health:

• GLP-1 Daily Support: This supplement is formulated to provide daily support for metabolic health. You can purchase it directly here: GLP-1 Daily Support.
• Weight Loss Boost: Designed to give your weight loss efforts an extra edge, this supplement is available for immediate purchase here: Weight Loss Boost.

These quick-access options are perfect for those looking for immediate support, whether they are on a prescription program or simply enhancing their general wellness.

Our commitment is to provide you with the tools and support you need to achieve your health goals safely and effectively. Whether you’re considering the combined therapy of Metformin and Ozempic, or exploring other avenues, our personalized approach is designed to guide you every step of the way.

Conclusion

The question should you take Metformin and Ozempic together is one that many individuals managing Type 2 diabetes and pursuing weight loss consider. As we’ve thoroughly explored, for a significant number of people, the combined use of these two powerful medications, under proper medical supervision, offers a highly effective and synergistic strategy. Metformin lays a crucial foundation by improving insulin sensitivity and reducing the liver’s glucose production, while Ozempic, a GLP-1 receptor agonist, enhances insulin secretion, slows gastric emptying, and promotes a profound sense of satiety. Together, they create a comprehensive approach that can lead to superior blood sugar control, more significant weight loss, and invaluable cardiovascular and kidney protection.

However, the decision to combine these treatments is never a one-size-fits-all solution. It necessitates a deep understanding of each medication’s mechanisms, potential side effects—especially the additive nature of gastrointestinal issues—and individual health profiles. The importance of a personalized approach, guided by a licensed medical professional, cannot be overstated. They are essential in assessing your unique needs, monitoring your progress, and mitigating any potential risks, ensuring your journey is both safe and effective.

At TrimRx, this commitment to individualized, medically supervised care is at the very core of our mission. Our innovative telehealth platform was built on the vision of making sustainable weight loss and improved health attainable through science, empathy, and transparency. We pride ourselves on offering a supportive, user-friendly space where you can connect with medical professionals who will craft a treatment plan specifically for you, whether that involves prescription medications like Ozempic, compounded Semaglutide, or other tailored solutions. Our comprehensive service, encompassing doctor consultations, lab work, medication, unlimited support, and convenient shipping from FDA-registered and inspected pharmacies, is designed to empower you with confidence and clarity on your health journey.

Your path to healthier living is personal, and it deserves a partner who understands and supports that individuality. We invite you to take the first step towards a healthier, more vibrant future. To discover if a personalized prescription weight loss program, potentially including the powerful combination of Metformin and Ozempic, is right for you, we encourage you to take our free assessment quiz today. Alternatively, to provide immediate support for your wellness goals, explore our range of quick-access supplements like GLP-1 Daily Support and Weight Loss Boost, available for purchase without a quiz. Together, we can unlock your potential for sustainable health and well-being.

Frequently Asked Questions

1. Can I take Metformin and Ozempic without a doctor’s prescription?

No, both Metformin and Ozempic are prescription medications that require a licensed healthcare provider’s evaluation and prescription. Self-medicating or using these drugs without proper medical supervision can be dangerous and lead to serious health complications. A medical professional will assess your health history, current conditions, and other medications to determine if these treatments are safe and appropriate for you, and to monitor your progress and manage any potential side effects. TrimRx’s program includes doctor consultations to ensure medically supervised care.

2. What specific side effects should I watch out for when taking Metformin and Ozempic together?

When taking Metformin and Ozempic together, you should be particularly aware of gastrointestinal side effects such as nausea, vomiting, diarrhea, and abdominal pain, as these can be common with both medications and potentially more pronounced in combination. Additionally, while less common, be vigilant for signs of serious risks: for Metformin, watch for symptoms of lactic acidosis (e.g., unusual muscle pain, difficulty breathing, stomach discomfort, weakness); for Ozempic, be aware of symptoms related to pancreatitis (severe abdominal pain, with or without vomiting) or potential thyroid issues (a lump or swelling in your neck, hoarseness). Always report any concerning or persistent side effects to your healthcare provider immediately.

3. Does combining Metformin and Ozempic guarantee weight loss?

While both Metformin and Ozempic have demonstrated significant potential for weight loss, especially when used in combination with diet and exercise, there is no guarantee of specific outcomes. Weight loss results can vary widely among individuals due to differences in metabolism, genetics, adherence to treatment, and lifestyle factors. However, for many, the synergistic actions of these medications can significantly enhance weight loss efforts compared to using either drug alone. TrimRx emphasizes that these medications are part of a personalized, holistic plan that includes medical supervision and support.

4. How does TrimRx support individuals considering the combination of Metformin and Ozempic?

TrimRx offers a comprehensive, personalized, and medically supervised approach for individuals considering medications like Metformin and Ozempic. Our platform connects you with licensed medical professionals who conduct thorough consultations and order necessary lab work to assess your eligibility and create a tailored treatment plan. This plan might include prescription medications such as Ozempic®, compounded Semaglutide, or other options from our diverse offerings. We provide unlimited support, transparent service, and convenient medication shipping from FDA-registered and inspected pharmacies. To begin, we encourage you to take our free assessment quiz to explore if these treatments align with your health and weight loss goals.