Navigating Calorie Intake: How Many Calories Do Individuals on Ozempic and GLP-1 Medications Eat?

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45 min
Published on
December 12, 2025
Updated on
December 12, 2025
Navigating Calorie Intake: How Many Calories Do Individuals on Ozempic and GLP-1 Medications Eat?

Introduction

Many individuals embarking on a weight loss journey often focus intently on the number of calories they consume. It’s a natural inclination, a quest for a tangible metric to guide their efforts. Yet, for those utilizing advanced weight management solutions like Ozempic and other GLP-1 medications, the landscape of calorie intake transforms dramatically. These medications don’t just reduce appetite; they fundamentally alter the body’s relationship with food, raising crucial questions about optimal nutrition and calorie targets. How does this powerful shift influence daily eating habits, and what are the critical nutritional considerations to ensure both effective weight loss and overall well-being?

Our discussion today aims to demystify the complexities of calorie intake for individuals on GLP-1 receptor agonists. We will delve into the science behind these medications, exploring how they influence hunger, satiety, and even food preferences. More importantly, we’ll uncover the nuanced approach to nutrition that moves beyond simply counting calories, emphasizing the importance of nutrient density, consistent eating patterns, and avoiding the pitfalls of under-eating. As pioneers in clinically proven, personalized weight loss solutions, we at TrimRx understand that sustainable weight loss should be achieved through science, empathy, and a transparent approach. Our commitment is to empower you with the knowledge to navigate this journey safely and effectively.

Throughout this comprehensive guide, we will explore the typical calorie ranges observed in individuals taking GLP-1s, the specific dietary choices that can maximize benefits and minimize side effects, and the broader lifestyle adjustments that are essential for long-term success. We believe in offering compassionate care that respects every individual’s unique journey by combining advanced medical science with modern technology. By the end, you will gain a deeper understanding of how to optimize your nutrition, support your body’s vital functions, and leverage the full potential of your personalized weight management plan with TrimRx.

Understanding GLP-1 Medications and Their Profound Impact on Appetite

The advent of GLP-1 receptor agonists, such as Ozempic (semaglutide), Wegovy, Mounjaro (tirzepatide), and Zepbound, marks a significant leap forward in addressing weight management and metabolic health. These medications are not merely appetite suppressants; they are sophisticated tools that interact with your body’s natural hunger and satiety signals in multiple intricate ways. At TrimRx, our journey began with a shared vision to help individuals embrace healthier lifestyles by merging cutting-edge telehealth innovations with effective weight loss solutions. Understanding the science behind these medications is fundamental to appreciating the personalized care we provide.

The Mechanism of Action: Mimicking Natural Hormones

At the heart of GLP-1 medications lies a remarkable ability to mimic the actions of glucagon-like peptide-1, a natural hormone produced in your gut when you eat. This hormone plays a pivotal role in regulating blood sugar and appetite. When you take a GLP-1 receptor agonist, it activates the same receptors that natural GLP-1 would, initiating a cascade of beneficial effects:

  • Enhanced Insulin Secretion: When blood sugar levels are high, these medications prompt the pancreas to release more insulin. This helps transport glucose from the bloodstream into cells, where it’s used for energy or stored, effectively lowering blood sugar.
  • Reduced Glucagon Production: GLP-1s also inhibit the release of glucagon, another hormone that typically increases blood sugar by signaling the liver to release stored glucose. By curbing glucagon, these medications prevent unnecessary sugar spikes.
  • Slowed Gastric Emptying: A key effect that directly impacts calorie intake is the slowing of gastric emptying. Food remains in the stomach for a longer period, contributing to a prolonged feeling of fullness and satiety. This physical sensation helps to naturally reduce the urge to eat more.
  • Direct Brain Communication: Perhaps the most significant influence on appetite comes from the medication’s direct interaction with the brain’s appetite control centers, particularly the hypothalamus. This communication helps to reduce “food noise”—those intrusive thoughts and constant cravings for food—and lowers overall food-seeking behaviors.

This multifaceted approach leads to a substantial reduction in hunger and an increased sense of fullness, which in turn, naturally leads to a decrease in overall calorie consumption. Research indicates that individuals on these medications may consume significantly fewer calories—with some studies pointing to a reduction of 720 to 990 calories per day compared to those not on the medication. This profound effect underscores why these medications are considered powerful tools in the realm of weight management, offering a pathway for individuals who have struggled with weight loss through conventional methods.

More Than Just Weight Loss: Metabolic Benefits

While the weight loss aspect of GLP-1 medications is often highlighted, it’s crucial to remember their fundamental role in metabolic health. For individuals with type 2 diabetes, medications like Ozempic (semaglutide) significantly improve hemoglobin A1c levels, a long-term marker of blood sugar control. This metabolic improvement is a cornerstone of the health benefits these medications offer. At TrimRx, our holistic view encompasses not just the numbers on the scale, but your overall metabolic well-being, aligning with our commitment to safe, effective weight loss and individualized care. Our platform is a user-friendly and supportive space where individuals receive personalized, medically supervised care, all designed to make sustainable weight loss attainable and tailored to the individual.

If you are considering how these medications might fit into your health goals, we encourage you to take our free assessment quiz to determine your eligibility and receive a personalized treatment plan.

The Calorie Landscape for Individuals on GLP-1 Medications

When considering how many calories individuals on Ozempic and similar GLP-1 medications eat, it’s important to understand that there isn’t a single, universally prescribed calorie target. Instead, the medication’s primary action—reducing appetite and increasing satiety—naturally guides individuals toward a reduced intake. This often falls within a range of approximately 1200-2000 calories per day, but this can vary significantly based on individual factors like starting weight, activity level, metabolic rate, and specific medication response.

The remarkable aspect of GLP-1 medications is that they facilitate this calorie reduction without requiring strenuous willpower or constant deprivation. The physiological changes induced by the medication make eating less feel more natural and less of a struggle.

Shifting Food Preferences and Choices

Beyond merely reducing the quantity of food consumed, GLP-1 medications can also profoundly impact the types of food individuals choose. New research suggests that people on these medications tend to make very distinct dietary shifts:

  • Reduced Intake of Processed Foods: There’s a noticeable decrease in the consumption of processed foods, sugary drinks, refined grains, and even certain meats like beef. The appeal of these typically palatable, high-calorie items seems to diminish.
  • Increased Intake of Nutrient-Dense Foods: Conversely, individuals often gravitate towards healthier options, such as more fruits and leafy greens, and tend to drink more water. This shift towards nutrient-dense foods is incredibly beneficial for overall health and supports weight loss efforts.
  • Altered Reward Pathways: While some individuals report still “wanting” processed foods or sugary items, they ultimately don’t consume them. This suggests an altered brain activity related to reward-seeking behaviors associated with food. The medication can effectively dampen the “desirable food cues,” meaning that even if the thought crosses one’s mind, the strong compulsion to eat it is lessened or absent. This fundamental change in food preference is crucial for sustained weight loss and for building new, healthier habits.

The Role of Side Effects in Calorie Regulation

It’s also worth noting that the mechanism of action of GLP-1 medications, particularly the slowing of gastric emptying, can lead to gastrointestinal side effects such as nausea, bloating, and discomfort if an individual overeats. These potential symptoms act as a natural deterrent, further encouraging smaller portion sizes and a more mindful approach to eating. While these side effects are typically managed through careful titration of the medication dose by a healthcare professional, they reinforce the body’s new signals for satiety and portion control.

At TrimRx, we emphasize that these medications are a tool to help you make sustainable changes. Our commitment to transparent service means our approach remains consistent regardless of dosage changes, and our focus on safety is paramount, working exclusively with FDA-registered and inspected pharmacies. Our comprehensive service includes doctor consultations, medication, lab work, unlimited support, and shipping, all designed to guide you through this transformative process with no hidden fees.

For those interested in exploring how a personalized plan could redefine their relationship with food and weight, we invite you to take our free assessment quiz and see if you qualify for our prescription weight loss medications.

The Critical Importance of Avoiding Under-Eating on GLP-1 Medications

While the primary goal of GLP-1 medications is to facilitate weight loss by reducing calorie intake, it’s a common misconception that eating as little as possible will accelerate results. In reality, severely restricting calories while on these medications can be counterproductive and even detrimental to your health. Your body, even when supported by GLP-1s, still requires essential nutrients and a sufficient calorie supply to maintain vital functions, preserve muscle mass, and prevent metabolic slowdown.

At TrimRx, we believe in a balanced, science-backed approach. We advocate for a strategy that ensures adequate nutrition, even as your appetite diminishes. Here’s why under-eating can be a significant pitfall:

The Detrimental Effects of Excessive Calorie Restriction

Muscle Loss

When you create a calorie deficit for weight loss, your body needs to draw energy from its stored reserves. If calorie intake is too low, and especially if protein intake is insufficient, your body will begin to break down muscle tissue for energy, even before tapping into fat stores. Losing muscle mass is a critical concern because muscle is metabolically active tissue. A reduction in muscle mass leads to a slower metabolism, making it harder to burn calories and significantly increasing the likelihood of weight regain once the medication is stopped or intake increases. This undermines the goal of long-term, sustainable weight management.

Slower Metabolism and Organ Dysfunction

Extreme calorie restriction signals to your body that it’s in a state of famine. In response, your metabolism slows down to conserve energy. This adaptive thermogenesis means your body becomes incredibly efficient at using fewer calories, making further weight loss challenging. Furthermore, vital organs like your heart and liver can become less efficient when not adequately fueled. The digestive system also suffers; the gut’s ability to move contents through the system decreases, exacerbating issues like bloating, constipation, and general discomfort, which are already potential side effects of GLP-1 medications.

Brain Fog and Lack of Focus

Your brain is a high-energy organ, consuming approximately 20% of your daily calories and primarily relying on glucose as its fuel source. Without an adequate supply of carbohydrates, which break down into glucose, you may experience symptoms like brain fog, difficulty concentrating, memory issues, and overall mental fatigue. This can impact daily functioning, work performance, and your overall quality of life.

Low Energy and Increased Risk of Injury

A severe calorie deficit leads to persistent fatigue, making it challenging to engage in physical activity. Exercise is an essential component of a healthy weight loss journey, helping to preserve muscle, improve cardiovascular health, and boost mood. When your muscles lack sufficient energy, workout performance suffers, and the risk of injuries increases due to poor form and reduced strength.

Binge Eating and Digestive Discomfort

Paradoxically, aggressive calorie restriction can sometimes lead to rebound binge eating. When the body is deprived for too long, hunger hormones can spike, overriding the appetite-suppressing effects of GLP-1s and leading to episodes of overeating. Given that GLP-1s slow digestion, consuming large portions after a period of restriction can cause severe gastrointestinal discomfort, intense nausea, and even vomiting, reinforcing an unhealthy cycle rather than promoting sustainable habits.

At TrimRx, we emphasize that prescription weight loss medications like Compounded Semaglutide, Oral Semaglutide, Ozempic®, Compounded Tirzepatide, Oral Tirzepatide, Mounjaro®, Zepbound®, and Wegovy® are provided through FDA-registered, inspected, and approved pharmacies, ensuring the highest standards of safety. However, medication effectiveness is maximized when paired with thoughtful nutrition. This is why our comprehensive service includes doctor consultations and unlimited support, providing guidance to ensure you are nourishing your body correctly. For immediate support for overall wellness during your weight loss journey, explore our GLP-1 Daily Support and Weight Loss Boost supplements.

Optimizing Your Diet for Sustainable Success on GLP-1 Medications

Navigating your diet while on GLP-1 medications requires a strategic approach focused on nutrient density and mindful eating, rather than restrictive calorie counting. The goal is to maximize the benefits of the medication—reduced appetite and cravings—while ensuring your body receives all the necessary fuel and nutrients for optimal health and sustainable weight loss. At TrimRx, we stand by a personalized approach, offering compassionate care and expert guidance to help you craft a dietary plan that aligns with your unique needs and the profound changes brought about by GLP-1 therapy.

Prioritizing Key Macronutrients and Hydration

### Lean Protein for Muscle Preservation and Satiety

Protein is paramount, especially during weight loss. It helps preserve lean muscle mass, which is crucial for maintaining a healthy metabolism and preventing weight regain. Protein also contributes significantly to satiety, helping you feel fuller for longer.

  • Intake Recommendations: While general recommendations suggest around 0.8 grams of protein per kilogram of body weight, many experts advise a higher intake, closer to 1.0 to 1.2 grams per kilogram, for individuals actively losing weight, particularly on GLP-1s.
  • Optimal Sources: Focus on lean proteins such as chicken breast, turkey, fish (salmon, cod, tuna), seafood, eggs, Greek yogurt, low-fat cottage cheese, and plant-based options like tofu, tempeh, lentils, and beans.
  • Distribution: Aim to include a high-quality protein source at every meal and snack to ensure a steady supply throughout the day. This can help prevent muscle catabolism and keep hunger at bay.

### Fiber-Rich Foods for Digestive Health and Fullness

Fiber is your digestive system’s best friend, especially when GLP-1 medications are slowing down gastric emptying, which can sometimes lead to constipation.

  • Benefits: Fiber adds bulk to your diet, promoting feelings of fullness and aiding in healthy bowel movements. It also helps regulate blood sugar levels, preventing spikes and crashes.
  • Excellent Sources: Load up on non-starchy vegetables (leafy greens, broccoli, bell peppers, carrots, zucchini), fruits (berries, apples, citrus), whole grains (quinoa, brown rice, whole-wheat bread and pasta, oats), and legumes.

### Healthy Fats in Moderation

Healthy fats are essential for hormone production, nutrient absorption, and long-term satiety. However, since GLP-1 medications slow digestion, consuming very high-fat meals can exacerbate gastrointestinal discomfort.

  • Mindful Choices: Opt for monounsaturated and polyunsaturated fats found in avocados, nuts, seeds (chia, flax, hemp), and olive oil.
  • Portion Control: Integrate these fats in moderation to harness their benefits without causing digestive distress.

### Consistent Hydration

Staying adequately hydrated is critical for overall health, digestion, and preventing common side effects like constipation.

  • Fluid Intake: Prioritize water throughout the day. Herbal teas, infused water, and even water-rich foods like watermelon, cucumbers, and lettuce can contribute to your fluid intake.
  • Avoid Sugary Drinks: Steer clear of sodas, fruit juices with added sugar, and sweet teas, as they add empty calories and can interfere with blood sugar regulation.

Strategic Eating Patterns and Food Choices

### Smaller, More Frequent Meals

Given the slowed gastric emptying, consuming large meals can lead to significant discomfort, bloating, and nausea.

  • Recommendation: Opt for 4-6 smaller meals or snacks spaced every 2-3 hours. This approach supports consistent nutrient intake, helps manage blood sugar, and prevents the feeling of being overly full.
  • Soft and Liquid Foods: When appetite is particularly low, especially during dose escalation, prioritize soft or liquid-based meals like smoothies, protein shakes, soups, yogurt, and cottage cheese. These are easier to digest while still providing essential nutrients.

### Emphasize Whole, Nutrient-Dense Foods

GLP-1 medications offer a unique opportunity to reset your eating habits. Focus on whole, unprocessed foods that provide a wealth of vitamins, minerals, and antioxidants.

  • Mediterranean-Style Eating: Many healthcare professionals recommend an eating plan akin to the Mediterranean diet, which emphasizes vegetables, fruits, whole grains, lean proteins, and healthy fats, while limiting processed foods, added sugars, and unhealthy fats.
  • Limit Problematic Foods: Avoid or severely limit fried foods, fast food, greasy dishes, refined carbohydrates (white bread, pastries), sugary snacks, and ultra-processed items. These foods are not only low in nutritional value but are also more likely to trigger adverse GI symptoms on GLP-1 medications due to their fat and sugar content and difficult digestibility.

The Role of Physical Activity and Professional Guidance

### Incorporate Regular Exercise

Exercise is not just about burning calories; it’s vital for preserving muscle mass, improving insulin sensitivity, boosting metabolism, and enhancing overall well-being.

  • Resistance Training: Aim for 3-4 sessions of strength training per week, using weights or bodyweight exercises. This is crucial for maintaining muscle and preventing metabolic slowdown.
  • Daily Movement: Incorporate light cardio like walking, yoga, or stretching daily. Even walking after meals can help regulate blood sugar levels.

### Partner with Healthcare Professionals

The most effective way to optimize your diet and lifestyle on GLP-1 medications is through personalized guidance from medical experts. This ensures your plan is tailored to your unique health profile, medication response, and evolving needs.

At TrimRx, we embody this personalized approach. We encourage you to take our free assessment quiz to determine your eligibility for our prescription weight loss medications. Our comprehensive service includes doctor consultations to fine-tune your dietary strategies, medication provided through FDA-registered, inspected, and approved pharmacies, lab work, unlimited support, and convenient shipping, all without hidden fees. We are dedicated to ensuring your journey is safe, effective, and tailored to you, supporting you every step of the way to a healthier lifestyle. Our GLP-1 Daily Support and Weight Loss Boost supplements are also available for immediate purchase to further support your overall wellness. Explore them here: GLP-1 Daily Support and Weight Loss Boost.

TrimRx’s Personalized Approach to Weight Management

At TrimRx, we understand that true weight management extends beyond just medication. It’s about a holistic, science-backed approach tailored to your unique physiology and lifestyle. Our journey began with a shared vision to help individuals embrace healthier lifestyles by merging cutting-edge telehealth innovations with effective weight loss solutions. This vision is deeply embedded in our personalized approach, ensuring that your path to sustainable weight loss is both effective and supportive.

Merging Innovation with Individualized Care

Our brand is empathetic, innovative, trustworthy, supportive, results-oriented, and profoundly personalized. We recognize that each individual’s experience with weight loss and GLP-1 medications is unique. The typical calorie intake, specific dietary needs, and potential side effects can vary widely from person to person. This is why a one-size-fits-all approach simply doesn’t yield the best results.

Our platform provides a user-friendly and supportive space where individuals receive personalized, medically supervised care. This means that when you engage with TrimRx, you’re not just getting a prescription; you’re gaining a partner dedicated to your health journey. We offer compassionate care that respects every individual’s unique journey by combining advanced medical science with modern technology.

Our Comprehensive Service: Your Foundation for Success

We are committed to transparent service, highlighting that our approach remains consistent regardless of dosage changes, and our focus on safety is unwavering. We work exclusively with FDA-registered and inspected pharmacies for the shipping of weight loss medications. Our comprehensive service is designed to cover all aspects of your weight management journey, ensuring you have the tools and support you need:

  • Doctor Consultations: Our licensed healthcare professionals conduct thorough assessments to understand your health history, current condition, and weight loss goals. These consultations are crucial for determining your eligibility for prescription medications and for developing a personalized treatment plan that includes dietary guidance and lifestyle recommendations.
  • Personalized Medication Plans: For eligible individuals, we offer access to a range of clinically proven prescription weight loss medications, including Compounded Semaglutide, Oral Semaglutide, Ozempic®, Compounded Tirzepatide, Oral Tirzepatide, Mounjaro®, Zepbound®, and Wegovy®. It’s important to note that our compounded medications are provided through FDA-registered and inspected pharmacies. Ozempic®, Mounjaro®, Zepbound®, and Wegovy® are branded medications that have received FDA approval.
  • Lab Work: To ensure safety and monitor your progress effectively, necessary lab work is incorporated into your personalized plan, providing vital insights into your metabolic health.
  • Unlimited Support: Your journey doesn’t end with a prescription. We offer unlimited support from our care team, allowing you to ask questions, share concerns, and receive ongoing guidance throughout your treatment.
  • Convenient Shipping: Medications are discreetly shipped directly to your door from FDA-registered and inspected pharmacies, ensuring convenience and adherence to the highest safety standards.
  • No Hidden Fees: We believe in clarity and transparency, which means our comprehensive service comes without any unexpected costs.

Empowering Your Choice with Quick-Access Supplements

Beyond our personalized prescription programs, we also offer quick-access supplements designed to support your overall wellness during your weight loss journey. These supplements do not require an assessment quiz and are available for immediate purchase:

  • GLP-1 Daily Support: Designed to complement your weight management efforts, this supplement supports the body’s natural processes.
  • Weight Loss Boost: This supplement provides additional support for metabolic function and energy.

We believe in empowering you with choices that align with your health objectives, whether you’re seeking a medically supervised prescription program or supplemental support for your well-being.

Your Next Step Towards Sustainable Weight Loss

Understanding how many calories individuals on Ozempic and other GLP-1 medications eat is just one piece of a larger, personalized puzzle. The true success of your weight loss journey hinges on a comprehensive approach that integrates expert medical guidance, thoughtful nutrition, and unwavering support. At TrimRx, we are dedicated to providing just that.

We encourage you to take the first step towards a healthier you. Discover if a personalized, medically supervised weight loss program is right for you by taking our free assessment quiz today. Let us partner with you to achieve your weight loss goals safely, effectively, and sustainably.

Conclusion

The journey of weight loss with GLP-1 medications like Ozempic marks a significant paradigm shift, moving beyond traditional calorie counting to embrace a more nuanced understanding of appetite regulation and metabolic health. While there’s no fixed calorie target, individuals on these medications typically find themselves consuming between 1200-2000 calories per day, driven by the profound effects on hunger and satiety. This natural reduction is complemented by a beneficial shift towards nutrient-dense foods and away from processed, high-calorie options.

However, the power of these medications also brings the crucial responsibility of proper nutritional management. We’ve underscored the vital importance of avoiding under-eating, which can lead to muscle loss, metabolic slowdown, cognitive impairment, and other adverse health outcomes, ultimately hindering long-term success. Instead, prioritizing lean protein, ample fiber, healthy fats in moderation, and consistent hydration through smaller, more frequent meals is key to optimizing both weight loss and overall well-being.

At TrimRx, we stand as your dedicated partner in this transformative journey. Our foundation is built on science, empathy, and transparency, offering personalized, medically supervised care that integrates cutting-edge telehealth with proven weight loss solutions. Our comprehensive service, which includes doctor consultations, medication sourced from FDA-registered and inspected pharmacies, lab work, and unlimited support, ensures that your path to sustainable weight loss is guided, safe, and effective.

Embrace this opportunity to redefine your relationship with food and achieve lasting health. Take the proactive step towards discovering a personalized plan tailored just for you. We invite you to take our free assessment quiz and explore how TrimRx can empower your weight loss journey. For immediate support, our GLP-1 Daily Support and Weight Loss Boost supplements are readily available to complement your wellness goals. Together, we can build a healthier, more vibrant future.

Frequently Asked Questions

Q1: How many calories should I aim for when taking Ozempic or other GLP-1 medications?

While there isn’t a strict, universal calorie target, most individuals on Ozempic and similar GLP-1 medications naturally gravitate towards an intake of 1200-2000 calories per day due to the medication’s effects on appetite and satiety. The precise number will vary based on individual factors like your basal metabolic rate, activity level, starting weight, and specific response to the medication. It is crucial to focus on consuming nutrient-dense foods within this reduced intake rather than strictly adhering to a low number. A personalized plan developed with healthcare professionals, like those at TrimRx, can help you determine the optimal range for your body and goals. We encourage you to take our free assessment quiz for tailored guidance.

Q2: What are the most important foods to prioritize while on GLP-1 medications?

To maximize the benefits of GLP-1 medications and ensure overall health, prioritize lean proteins (chicken, fish, eggs, tofu), fiber-rich foods (non-starchy vegetables, fruits, whole grains, legumes), and healthy fats in moderation (avocado, nuts, olive oil). These foods support muscle preservation, promote satiety, aid digestion, and provide essential nutrients. It’s equally important to limit ultra-processed foods, sugary drinks, and excessive high-fat foods, as they can cause discomfort and hinder progress. Our GLP-1 Daily Support supplement can also complement your nutrient intake.

Q3: What happens if I don’t eat enough calories while taking Ozempic?

Under-eating on GLP-1 medications can lead to several negative health consequences, despite the desire to lose weight quickly. These can include muscle loss, which slows your metabolism and makes long-term weight maintenance difficult. You may also experience brain fog, low energy levels, increased risk of injuries due to fatigue, and even digestive issues like constipation or severe discomfort if you overeat after a period of extreme restriction. It is essential to ensure adequate calorie and nutrient intake to support your body’s vital functions and achieve sustainable, healthy weight loss.

Q4: How does TrimRx support my dietary needs while on weight loss medication?

TrimRx offers a comprehensive and personalized approach to support your dietary needs. Through doctor consultations, our licensed healthcare professionals will assess your individual requirements and provide tailored dietary guidance to complement your medication. Our service includes unlimited support from our care team, allowing you to discuss any nutritional challenges or questions you may have. Additionally, our quick-access supplements, such as GLP-1 Daily Support and Weight Loss Boost, are available to support your overall wellness. Our goal is to ensure you have all the resources for safe, effective, and sustainable weight loss.

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