Navigating Weight Loss: Can You Take Ozempic If You Have Gastritis?

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48 min
Published on
September 20, 2025
Updated on
September 20, 2025
Navigating Weight Loss: Can You Take Ozempic If You Have Gastritis?

Introduction

The journey toward sustainable weight loss often feels like navigating a complex landscape, filled with questions, hopes, and sometimes, unexpected challenges. For many, the prospect of managing weight is not just about aesthetics; it’s about reclaiming health, energy, and overall well-being. Modern medical advancements have introduced powerful tools like GLP-1 receptor agonists, with Ozempic® (semaglutide) standing out as a notable option, recognized for its efficacy in both type 2 diabetes management and weight loss support. However, alongside the promise of these innovative treatments, specific health considerations frequently arise, particularly concerning digestive health.

One question we often encounter from individuals exploring weight loss solutions is whether these medications are suitable when pre-existing conditions like gastritis are present. Gastritis, an inflammation of the stomach lining, can introduce a layer of complexity to any treatment plan, especially one that impacts the digestive system. Understanding the interplay between such medications and gastric health is not just crucial—it’s foundational to ensuring a safe and effective weight loss journey.

This comprehensive guide aims to illuminate the relationship between Ozempic® and gastritis. We will delve into how these medications work, their potential digestive side effects, and critically, what individuals with gastritis need to consider. Our purpose is to provide clarity and empower you with the knowledge necessary to have informed discussions with healthcare professionals. We’ll explore strategies for managing gastric symptoms, emphasize the paramount importance of personalized medical supervision, and illustrate how a tailored approach can make a profound difference. By the end of this post, you will have a deeper understanding of these factors, ensuring you are well-equipped to make informed decisions about your health and weight loss journey.

Understanding Ozempic® and Gastritis

To fully address the question of whether one can take Ozempic® with gastritis, it’s essential to first establish a clear understanding of both components. This foundational knowledge will help us explore the potential interactions and considerations with greater clarity.

What is Ozempic® (Semaglutide)?

Ozempic® is a brand-name medication that contains semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist. Originally developed and FDA-approved for the management of type 2 diabetes, its remarkable effects on weight loss have also led to its use in broader weight management programs. Similar to the naturally occurring GLP-1 hormone in the body, semaglutide works through several key mechanisms:

  • Slowing Gastric Emptying: It delays how quickly food leaves the stomach, leading to a prolonged feeling of fullness. This mechanism is crucial for both blood sugar control and appetite suppression.
  • Suppressing Appetite: By acting on receptors in the brain, it helps reduce hunger and food cravings, leading to decreased calorie intake.
  • Stimulating Insulin Release: In response to high blood sugar, it prompts the pancreas to release more insulin.
  • Reducing Glucagon Secretion: It lowers the amount of glucagon, a hormone that raises blood sugar.

These combined actions contribute significantly to blood sugar control and, notably, to sustained weight loss for many individuals. At TrimRx, we offer access to Ozempic® as part of our personalized treatment plans, alongside other GLP-1 medications like Wegovy®, Mounjaro®, and Zepbound®, ensuring a range of medically supervised options for our patients.

What is Gastritis?

Gastritis refers to the inflammation or irritation of the stomach lining. This condition can be acute, appearing suddenly and severely, or chronic, developing slowly over time. The causes of gastritis are varied and can include:

  • Bacterial Infection: Helicobacter pylori (H. pylori) is a common culprit.
  • Regular Use of NSAIDs: Nonsteroidal anti-inflammatory drugs like ibuprofen or aspirin.
  • Excessive Alcohol Consumption: Irritates the stomach lining.
  • Stress: Severe physical stress (e.g., from injury or surgery).
  • Autoimmune Reactions: The body’s immune system attacking stomach cells.
  • Bile Reflux: Bile flowing back into the stomach.

Common symptoms of gastritis often involve digestive discomfort and can include:

  • Abdominal pain or discomfort, often in the upper abdomen
  • Nausea
  • Vomiting
  • Indigestion or dyspepsia
  • A feeling of fullness in the upper abdomen after eating
  • Loss of appetite

Understanding these symptoms is vital, as some mirror the gastrointestinal side effects associated with GLP-1 medications. This overlap is precisely why individuals with pre-existing gastritis must approach such treatments with caution and expert medical guidance.

Ozempic® Side Effects: A Closer Look at Gastric Health

GLP-1 receptor agonists, while highly effective, are known to commonly induce gastrointestinal side effects due to their mechanism of slowing digestion. For individuals concerned about their stomach health, understanding these potential reactions is a crucial step in preparing for or managing treatment.

Common Digestive Side Effects of Semaglutide

The most frequently reported side effects of semaglutide, the active ingredient in Ozempic®, primarily affect the digestive system. These are typically mild to moderate and often subside as the body adjusts to the medication, usually within a few days to a few weeks. However, they may return or intensify with dose increases.

Very common side effects (affecting more than 1 in 10 people) include:

  • Feeling sick (nausea)
  • Being sick (vomiting)
  • Diarrhea
  • Constipation
  • Stomach pain

Common side effects (affecting up to 1 in 10 people) include:

  • Indigestion (dyspepsia)
  • Heartburn or acid reflux (GERD)
  • Gas (flatulence)
  • Inflammation of the stomach (gastritis)

It is important to note that gastritis itself is explicitly listed among the commonly reported side effects of semaglutide. This means that even individuals without a pre-existing condition could potentially develop gastritis while on the medication. Symptoms such as abdominal pain, nausea, vomiting, and indigestion should prompt a discussion with your healthcare provider.

Specific Observations Related to Ozempic® and Gastric Issues

While Ozempic®’s clinical studies did not explicitly report heartburn as a direct side effect, the prescribing information does mention several mild side effects that are often linked to or can exacerbate heartburn or gastritis:

  • Gastroesophageal Reflux Disease (GERD) / Acid Reflux: Can cause a burning sensation in the chest, neck, or throat, and a bitter taste in the mouth due to regurgitation of food or liquid.
  • Burping or Belching: Indicative of digestive gas.
  • Dyspepsia (Indigestion): Causes burning or discomfort in the upper abdomen.
  • Gastritis (inflammation or irritation of your stomach lining): As mentioned, this can cause nausea, vomiting, and fullness in the upper abdomen.
  • Gas: General abdominal discomfort from gas.

These side effects were reported with both 0.5 mg and 1 mg doses of Ozempic®, with a higher incidence generally observed at the 1 mg dose, except for gas. Anecdotal reports from individuals taking Ozempic® have indicated experiencing heartburn, sometimes intensely, affecting sleep and daily activities. This highlights the variability of individual responses and the importance of monitoring one’s symptoms closely.

Rare but Serious Gastric Concerns: Gastroparesis

Beyond the common digestive discomforts, it is crucial to be aware of rarer, more severe potential gastrointestinal complications. One such concern that has garnered attention is the potential development of gastroparesis, sometimes referred to as “stomach paralysis.” This condition involves significantly delayed gastric emptying, where food remains in the stomach for an abnormally long time, disrupting its normal movement into the small intestine.

Symptoms of gastroparesis can be severe and include:

  • Persistent indigestion and upper abdominal pain
  • Severe bloating
  • Frequent nausea and vomiting
  • Regurgitation of undigested food
  • Significant loss of appetite
  • Severe acid reflux and heartburn
  • Unpredictable blood sugar fluctuations

The complications arising from severe gastroparesis can be serious:

  • Dehydration: Due to repeated vomiting.
  • Malnutrition: From poor nutrient absorption and reduced food intake.
  • Difficulty Controlling Blood Sugar Levels: Particularly challenging for individuals with diabetes, as delayed food movement makes insulin timing difficult.
  • Bezoars: Solid masses of undigested food that can form in the stomach. These can lead to blockages, ulcers, and bleeding, and in severe cases, can be life-threatening if they prevent food from moving to the small intestine.

While these severe conditions are rare, it underscores the necessity of continuous medical supervision throughout treatment with GLP-1 medications. Any persistent or severe abdominal pain or digestive distress must be immediately reported to a healthcare professional. We at TrimRx are committed to ensuring that every individual under our care receives thorough evaluations and ongoing support to minimize such risks.

Other Rare Side Effects to be Aware Of

While the focus here is on gastric issues, for a comprehensive understanding, it’s worth noting other rare but serious side effects associated with semaglutide:

  • Hypoglycemia (Low Blood Sugar): A risk, especially for those with type 2 diabetes taking other medications like sulfonylureas or insulin. Symptoms include dizziness, blurred vision, anxiety, sweating, shakiness, confusion, and difficulty concentrating.
  • Gallbladder Problems: Such as gallstones, which can cause severe upper stomach pain, jaundice, fever, and clay-colored stools.
  • Kidney Problems or Kidney Failure: Can be worsened by severe vomiting and diarrhea, emphasizing the need for hydration.
  • Inflammation of the Pancreas (Pancreatitis): Causes severe abdominal pain that may radiate to the back. This requires immediate medical attention and discontinuation of treatment.
  • Potential Thyroid and Pancreatic Cancer Risks: While not conclusively proven in humans, animal studies suggest potential thyroid C-cell tumor risks. It’s crucial to avoid semaglutide if there’s a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • Allergic Reactions: Rare but can be severe, indicated by rash, itching, trouble breathing or swallowing, swelling of the face/mouth/throat, dizziness, or a rapid heartbeat.

Recognizing these symptoms and seeking prompt medical help is paramount. Our commitment at TrimRx includes providing clear information and facilitating access to professional medical advice to ensure safety.

Navigating Ozempic® with Pre-existing Gastritis

This brings us to the core question: can you take Ozempic if you have gastritis? The answer is not a simple yes or no; it is nuanced and depends entirely on a thorough, personalized medical evaluation. For individuals with a pre-existing diagnosis of gastritis, the decision to use Ozempic® or any GLP-1 medication requires careful consideration by a qualified healthcare provider.

The Critical Role of Medical Supervision

The presence of gastritis significantly impacts the risk-benefit assessment for GLP-1 therapy. Because these medications are known to induce gastrointestinal side effects, including the potential for new onset gastritis or exacerbation of existing inflammation, strict medical supervision is not just recommended, but essential.

At TrimRx, our journey began with a shared vision to help individuals embrace healthier lifestyles through personalized, medically supervised care. This means that before starting any prescription weight loss medication, including Ozempic®, individuals must complete our free assessment quiz. This quiz is designed to gather vital health information, which is then reviewed by our network of licensed medical professionals. They will determine eligibility and craft a personalized treatment plan tailored to your unique health profile, including any pre-existing conditions like gastritis.

Factors for Consideration During Consultation

When consulting with a healthcare provider about taking Ozempic® with gastritis, several critical factors will be assessed:

  • Severity and Type of Existing Gastritis: Is it acute or chronic? What is its underlying cause? How well-controlled are the symptoms? Mild, well-managed gastritis might pose a different risk profile than severe, active inflammation.
  • Current Symptoms and Medication: What are your current gastritis symptoms? Are you taking any medications (e.g., PPIs, H2 blockers, antacids) to manage it? These details help determine the potential for interaction and the need for dosage adjustments for either medication.
  • Other Medical Conditions: Any other chronic conditions, especially those affecting the kidneys, gallbladder, or pancreas, will be taken into account due to the rare side effects associated with GLP-1s.
  • Overall Health Profile: Your age, lifestyle, and other health markers contribute to the holistic assessment.

Your physician will weigh the potential benefits of weight loss and improved metabolic health against the risks of exacerbating your gastritis or introducing new gastrointestinal complications. This involves a detailed discussion about your medical history, current health status, and expectations for treatment.

Individualized Care and Risk Assessment

We believe that sustainable weight loss should be achieved through science, empathy, and a transparent approach. This philosophy guides our personalized programs. For individuals with gastritis, our medical professionals will conduct a thorough risk assessment, which may include:

  • Reviewing your diagnostic history for gastritis.
  • Discussing past and present symptoms and how they impact your daily life.
  • Considering the potential impact of GLP-1’s delayed gastric emptying on your specific condition.
  • Exploring alternative treatment paths or modifications if the risk of exacerbating gastritis is deemed too high.

In some cases, a physician might recommend a lower starting dose of medication and a slower titration schedule to allow the body more time to adjust, closely monitoring for any adverse reactions. Or, they might suggest focusing on managing your gastritis effectively before initiating GLP-1 therapy. Our compassionate care respects every individual’s unique journey, combining advanced medical science with modern technology to deliver personalized solutions.

If you have gastritis and are considering a GLP-1 medication like Ozempic®, the first and most crucial step is to seek professional medical advice. To see if you qualify for our personalized prescription weight loss medications, we encourage you to take our free assessment quiz today.

Strategies for Managing Gastric Side Effects and Supporting Digestive Health on GLP-1 Medications

For those who are approved to proceed with GLP-1 medications, especially with a history of gastritis, actively managing potential gastric side effects is paramount. A proactive approach involving dietary adjustments, lifestyle changes, and, when necessary, targeted medications can significantly improve comfort and adherence to the treatment plan.

Dietary Adjustments for Digestive Comfort

What you eat and how you eat can profoundly impact your digestive comfort while on GLP-1 medications. These strategies are particularly important for individuals managing gastritis.

Eating Habits

  • Eat Slowly and Mindfully: Rushing meals can lead to swallowing air and indigestion. Savoring your food allows your body to signal fullness more effectively.
  • Smaller Portion Sizes: Since GLP-1s slow gastric emptying, large meals can overwhelm the stomach and lead to discomfort, nausea, or a feeling of excessive fullness. Opt for several smaller meals throughout the day rather than two or three large ones.
  • Avoid Eating Close to Bedtime: Aim to finish meals and snacks at least 3 to 4 hours before lying down. This allows ample time for gastric emptying and reduces the risk of acid reflux.
  • Stay Hydrated: Drinking plenty of water is essential, especially if experiencing nausea, vomiting, or diarrhea. This helps prevent dehydration and supports overall digestive function. Ice-cold water or unsweetened herbal teas (like ginger or peppermint tea) can be particularly soothing.

Food Choices

Certain foods are known to exacerbate gastritis or trigger digestive upset, while others can be soothing.

Foods to Limit or Avoid:

  • Fatty, Greasy, or Fried Foods: These are harder to digest and can worsen nausea and stomach discomfort.
  • Sugary Foods: Can sometimes contribute to digestive upset for some individuals.
  • Spicy Foods: Can irritate the stomach lining, especially in gastritis.
  • High-Acid Foods and Beverages: Certain fruits (like tomatoes, pineapples, oranges), carbonated drinks, coffee, and even some teas can increase stomach acid production and worsen heartburn or gastritis symptoms.
  • Alcohol: Can directly irritate the stomach lining.

Beneficial Foods to Incorporate:

  • Light and Bland Foods: Plain rice, toast, crackers, applesauce, boiled potatoes, and lean protein can be easier on the stomach during periods of discomfort.
  • Ginger: Known for its anti-nausea properties. Ginger tea, ginger ale (flat, not carbonated), or small pieces of fresh ginger can be helpful.
  • Hot Broths: Can be soothing and help with hydration.
  • Bananas: Easy to digest and a good source of potassium.

Lifestyle Changes to Support Digestive Health

Beyond diet, several lifestyle modifications can help manage gastric symptoms:

  • Elevate Your Head While Sleeping: Using a wedge pillow or raising the head of your bed can help prevent stomach acid from refluxing into the esophagus, which is beneficial for heartburn and GERD.
  • Reduce Stress: Stress can significantly impact digestive health and exacerbate gastritis symptoms. Incorporating stress-reduction techniques like meditation, yoga, deep breathing exercises, or gentle walks can be beneficial.
  • Limit NSAID Use: If you have gastritis, it’s advisable to limit or avoid nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, as they can further irritate the stomach lining. Always consult your doctor for pain relief alternatives.
  • Consider Quitting Smoking: Smoking weakens the lower esophageal sphincter, increasing the risk of acid reflux and can generally worsen digestive issues.

Over-the-Counter (OTC) and Prescription Medications

While dietary and lifestyle changes are crucial, some individuals may require additional support from medications to manage persistent gastric side effects. It is vital to always consult your doctor or a TrimRx medical professional before taking any additional medication during your GLP-1 treatment.

  • Antacids: Provide quick relief by neutralizing stomach acid. Brands include Alka-Seltzer, Mylanta, Pepto-Bismol, Rolaids, and Tums.
  • Histamine-2 (H2) Blockers: Reduce the amount of acid your stomach produces. Examples include famotidine (Pepcid, Pepcid AC) and cimetidine (Tagamet, Tagamet HB).
  • Proton Pump Inhibitors (PPIs): Significantly reduce stomach acid production and are often prescribed for more severe or persistent acid reflux and gastritis. Examples include omeprazole (Prilosec), esomeprazole (Nexium), and pantoprazole (Protonix).
  • Antiemetic Tablets: For general nausea, antiemetic medications can be prescribed or recommended by your doctor.

Dose Adjustment under Medical Guidance

If you find yourself struggling with unmanageable side effects after increasing your GLP-1 dose, discuss this with your TrimRx medical provider. They may recommend dropping down to a lower dose for an extended period (e.g., another 4 weeks) to allow your body more time to adjust. If side effects persist, remaining on a lower, more tolerable dose for the duration of your treatment may be the best course of action to ensure safety and comfort. Our approach remains consistent regardless of dosage changes—we prioritize your well-being and transparent service.

TrimRx’s Comprehensive Support for Your Journey

At TrimRx, we understand that managing side effects is a crucial part of a successful weight loss journey. Our comprehensive service includes:

  • Doctor Consultations: Ensuring personalized advice and monitoring.
  • Medication: Access to a range of clinically proven options like Compounded Semaglutide, Oral Semaglutide, Compounded Tirzepatide, and Oral Tirzepatide, in addition to the branded options mentioned earlier.
  • Lab Work: To monitor your health throughout the program.
  • Unlimited Support: Our team is here to provide guidance, answer questions, and help you navigate challenges, including side effect management.
  • Shipping: Convenient delivery of your medication directly to you from FDA-registered and inspected pharmacies.

For immediate support to complement your weight loss journey, we also offer quick-access supplements that do not require a quiz:

Our dedication to safety is paramount; we work exclusively with FDA-registered and inspected pharmacies for the shipping of weight loss medications. We want to be clear that while branded medications like Ozempic® are FDA-approved, compounded medications are provided through these reputable pharmacies, ensuring quality and safety standards are met.

The TrimRx Difference: Personalized Care for Sustainable Weight Loss

At TrimRx, our entire philosophy revolves around providing safe, effective, and truly personalized weight loss solutions. We understand that confronting weight-related issues, especially with co-existing conditions like gastritis, requires more than a one-size-fits-all approach. It demands a partnership in health, where science meets empathy.

Our journey began with a shared vision: to help individuals embrace healthier lifestyles by merging cutting-edge telehealth innovations with clinically proven weight loss solutions. We recognized a need for a platform that is not only user-friendly but also a profoundly supportive space where individuals receive personalized, medically supervised care. Our goal is to make sustainable weight loss attainable and genuinely tailored to each individual’s specific needs and health profile.

Our Values in Action

We believe that sustainable weight loss should be achieved through science, empathy, and a transparent approach. This commitment forms the bedrock of our brand personality and messaging:

  • Empathetic: We offer compassionate care that respects every individual’s unique journey. We listen, understand, and provide support that acknowledges the complexities of weight management and conditions like gastritis.
  • Innovative: By combining advanced medical science with modern technology, we bring effective, convenient, and accessible weight loss solutions directly to you. Our telehealth platform is designed to seamlessly integrate into your life.
  • Trustworthy: Your safety and well-being are our top priorities. We operate with the highest standards of medical integrity, partnering exclusively with FDA-registered and inspected pharmacies for medication shipping and ensuring that all medical supervision is provided by licensed professionals.
  • Supportive: Our comprehensive programs extend beyond just medication. We provide unlimited support, guiding you through every step, from initial consultation to managing side effects and celebrating successes. We are your dedicated partner.
  • Results-Oriented: While respecting your individual journey, we are focused on helping you achieve meaningful and lasting health outcomes. Our programs are designed for effective, sustainable weight loss.
  • Personalized: This is perhaps the most critical aspect of the TrimRx difference. We recognize that no two individuals are alike. Your body, your health history, your challenges, and your goals are unique. This is why our approach begins with a detailed assessment to create a customized treatment plan that addresses your specific needs, including any pre-existing conditions like gastritis.

Our Comprehensive Service

When you choose TrimRx, you gain access to a service that includes:

We empower you with choices, offering both our personalized prescription weight loss programs (which begin with our free assessment quiz) and quick-access supplements like GLP-1 Daily Support and Weight Loss Boost to aid your overall wellness during your weight loss journey.

If you are struggling with weight-related issues and have concerns about conditions like gastritis, remember that a personalized, medically supervised approach is key. Don’t hesitate to explore your options. Take our free assessment quiz today to begin your journey toward a healthier you, guided by expert care and unwavering support.

Conclusion

The journey to sustainable weight loss is a personal one, often intertwined with unique health considerations, such as the presence of gastritis. As we’ve explored, medications like Ozempic® (semaglutide) offer powerful avenues for managing weight and improving metabolic health, but their interaction with the digestive system necessitates careful, informed decision-making.

For individuals asking, “can you take Ozempic if you have gastritis?”, the overarching message is clear: personalized medical supervision is non-negotiable. While gastritis is a known potential side effect of semaglutide, and the medication’s action of slowing gastric emptying can impact existing gastric conditions, the possibility of integrating these treatments exists under strict professional guidance. The key lies in a thorough evaluation of your specific health profile, the severity of your gastritis, and an individualized risk-benefit assessment conducted by a qualified healthcare provider.

Effective management of potential gastric side effects involves a multi-pronged approach encompassing mindful eating habits, strategic dietary choices, beneficial lifestyle modifications, and, when appropriate, adjunctive medications—always under the guidance of a medical professional. Your proactive engagement in these strategies, coupled with open communication with your care team, is essential for a comfortable and effective experience.

At TrimRx, we are deeply committed to empowering individuals with the knowledge and support needed to navigate their weight loss journey safely and effectively. Our platform is built on the principles of science, empathy, and transparency, offering a medically supervised, personalized approach to weight management. We believe that everyone deserves access to tailored solutions that respect their unique health story.

If you are considering a GLP-1 medication and have concerns about gastritis or other health conditions, we encourage you to take the vital first step. Let us partner with you in achieving your health goals. Take our free assessment quiz today to determine your eligibility for our prescription weight loss medications and embark on a path toward sustainable well-being with comprehensive support. Additionally, consider exploring our quick-access supplements, GLP-1 Daily Support and Weight Loss Boost, designed to further enhance your journey. Together, we can work towards a healthier, more vibrant future.

Frequently Asked Questions (FAQ)

Q1: Is gastritis a common side effect of Ozempic® (semaglutide)?

Yes, inflammation of the stomach, known as gastritis, is listed as a common side effect of semaglutide, affecting up to 1 in 10 people. Other common digestive side effects include nausea, vomiting, diarrhea, constipation, stomach pain, indigestion, and heartburn. These symptoms often subside as your body adjusts to the medication, but it’s important to discuss any concerns with your healthcare provider.

Q2: What should I do if I experience worsening gastritis symptoms while taking Ozempic®?

If you experience worsening gastritis symptoms or new, severe digestive issues while on Ozempic®, it is crucial to contact your medical provider immediately. They may recommend dose adjustments, specific dietary changes, or other medications to manage your symptoms. Do not adjust your medication dosage or take new medications without consulting a healthcare professional first. TrimRx offers unlimited support as part of our comprehensive program, allowing you to discuss any side effects with your medical team.

Q3: Are there specific foods I should avoid if I have gastritis and am taking Ozempic®?

Yes, certain foods can exacerbate gastritis symptoms and should be limited or avoided. These include fatty, greasy, or fried foods, spicy foods, highly acidic foods (like tomatoes, pineapples, oranges), carbonated drinks, coffee, and alcohol. Focusing on bland foods, smaller portions, and eating slowly can help reduce digestive discomfort. Our TrimRx team can provide further dietary guidance as part of your personalized plan.

Q4: How does TrimRx address concerns for individuals with pre-existing gastritis?

At TrimRx, we prioritize personalized, medically supervised care. If you have pre-existing gastritis, our free assessment quiz will gather your detailed health history. This information is then reviewed by our licensed medical professionals who will determine your eligibility for prescription weight loss medications, considering your gastritis. They will discuss the risks and benefits, create a tailored treatment plan, and provide ongoing support to manage any potential side effects. Your safety and comfort are paramount throughout your weight loss journey with us.

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