Optimizing Your Weight Loss Journey: What Supplements to Take with Ozempic

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47 min
Published on
September 21, 2025
Updated on
September 21, 2025
Optimizing Your Weight Loss Journey: What Supplements to Take with Ozempic

Introduction

Embarking on a weight loss journey often involves exploring various pathways to healthier living. For many, modern medical advancements, such as medications like Ozempic, have become significant tools in this pursuit. Originally developed to help manage type 2 diabetes by regulating blood sugar levels, Ozempic, which mimics the natural hormone GLP-1, has also gained considerable attention for its effectiveness in supporting substantial weight loss by curbing appetite and slowing gastric emptying. This scientific approach to weight management offers a promising route for individuals striving to achieve their health goals.

However, as exciting and transformative as this journey can be, it brings with it important considerations. Rapid or significant weight loss, while often desired, can sometimes lead to unintended consequences, including potential nutrient deficiencies, changes in body composition like muscle loss, or even concerns about skin elasticity. It’s not just about shedding pounds; it’s profoundly about ensuring that your body remains nourished, balanced, and vibrant throughout the entire process. This is where strategic supplementation and a holistic approach to nutrition become incredibly valuable.

In this comprehensive guide, we will delve into the crucial role that various supplements can play in complementing Ozempic treatment. Our purpose is to illuminate how specific vitamins, minerals, proteins, and other supportive nutrients can help bridge potential nutritional gaps, mitigate common side effects, and optimize your overall well-being. We’ll explore not only the essential building blocks your body needs but also targeted solutions like protein and collagen to support muscle preservation and skin health, and omega-3 fatty acids for anti-inflammatory benefits. By the end of this article, you will gain a deeper understanding of how to make informed choices about nutritional support, ensuring your weight loss journey is as healthy, effective, and sustainable as possible.

At TrimRx, our journey began with a shared vision: to empower individuals to embrace healthier lifestyles by merging cutting-edge telehealth innovations with effective, personalized weight loss solutions. We understand that each person’s path is unique, and our platform is designed to be a user-friendly and supportive space where individuals receive personalized, medically supervised care, all crafted to make sustainable weight loss attainable and tailored to the individual. We firmly believe that sustainable weight loss should be achieved through science, empathy, and a transparent approach, prioritizing your health and safety every step of the way. This article is crafted to reflect our commitment to providing you with the knowledge and tools needed to navigate your journey successfully.

Understanding Ozempic’s Impact on Your Nutrition

When considering a medication like Ozempic for weight management, it’s essential to grasp how it interacts with your body’s nutritional landscape. While profoundly effective, its mechanisms can create unique dietary considerations that proactive individuals will want to address.

How Ozempic Works for Weight Management

Ozempic is a glucagon-like peptide-1 (GLP-1) receptor agonist. This means it mimics the action of a natural hormone in your body called GLP-1. This hormone plays several crucial roles: it stimulates insulin release when blood sugar levels are high, which helps regulate blood glucose; it slows down gastric emptying, meaning food stays in your stomach longer; and significantly, it acts on the brain to reduce appetite and increase feelings of fullness or satiety.

For individuals striving for weight loss, these effects are incredibly beneficial. By reducing hunger and making you feel satisfied with smaller portions, Ozempic naturally leads to a substantial decrease in overall calorie intake. This calorie deficit is the fundamental principle behind weight loss, and Ozempic helps achieve it more comfortably and effectively for many. It’s a powerful tool that can help recalibrate your body’s hunger signals and metabolic responses.

The Risk of Nutrient Deficiencies

While the reduction in calorie intake is a key mechanism for weight loss with Ozempic, it also presents a potential challenge: the risk of nutrient deficiencies. When daily calorie consumption drops significantly—sometimes by as much as 40% for individuals taking GLP-1 medications, as studies suggest—the opportunities to consume essential vitamins, minerals, and macronutrients also decrease.

Many people find that their diets, even before starting medications, may already lack certain key nutrients. When food intake is further restricted, these pre-existing gaps can widen, and new deficiencies can emerge. For example, if you’re eating smaller meals and fewer varieties of foods, you might miss out on the diverse range of micronutrients found in a balanced diet. This isn’t just a hypothetical concern; research indicates that individuals on semaglutide drugs like Ozempic and Wegovy might fall short on dietary nutrients, including essential vitamins and minerals, which are crucial for every bodily function, from energy production to immune defense.

This highlights why nutritional support is not merely an optional addition but a vital component during a period of rapid weight loss. Without adequate nourishment, the body may not perform optimally, potentially leading to fatigue, compromised immune function, or even impact the health of your skin, hair, and nails. Ensuring comprehensive nutritional support becomes a cornerstone of a truly healthy and sustainable weight loss journey, helping you not just lose weight but thrive in your healthier lifestyle. This holistic perspective is precisely what we advocate at TrimRx, aiming to support your overall well-being.

Essential Vitamins and Minerals: Bridging the Nutritional Gap

As your body adjusts to reduced calorie intake while on Ozempic, proactively addressing potential nutritional gaps becomes paramount. Certain vitamins and minerals are particularly important to monitor and, if necessary, supplement, to ensure your body maintains optimal function.

Vitamin B12: Fueling Your Body’s Core Functions

Vitamin B12 is a powerhouse nutrient, absolutely essential for myriad bodily processes. It plays a critical role in the formation of red blood cells, which carry oxygen throughout your body. It’s also vital for maintaining a healthy nervous system, supporting DNA production, and facilitating your body’s energy metabolism. Most adults require approximately 2.5 micrograms (mcg) of B12 daily.

Several factors can increase the risk of B12 deficiency. These include older age (65 years and older), adherence to vegan or vegetarian diets (as B12 is primarily found in animal products), certain digestive tract disorders, a history of gastrointestinal surgery like gastric bypass, and long-term use of specific medications. Critically, if you are taking Ozempic alongside metformin, a common diabetes medication, your risk of vitamin B12 deficiency is even higher. Metformin is known to interfere with B12 absorption, potentially leading to low levels over time. Symptoms of deficiency can include fatigue, weakness, nerve-related issues, and in severe cases, anemia.

Given these considerations, it is highly beneficial to discuss your B12 levels with a healthcare professional, especially if you have any of the mentioned risk factors. Our comprehensive service at TrimRx includes doctor consultations and lab work precisely to identify such needs, ensuring you receive personalized recommendations. If levels are low, a daily B12 supplement, guided by your doctor, can help restore them.

Vitamin D: The Sunshine Nutrient for Bone and Immune Health

Often called the “sunshine vitamin,” Vitamin D is crucial for absorbing calcium, which is fundamental for building and maintaining strong bones and teeth. Beyond its skeletal role, Vitamin D also plays a significant part in supporting your immune system and proper nerve function. The Office of Dietary Supplements (ODS) recommends about 15 mcg (600 IU) daily for most adults, with older adults (65 and older) needing 20 mcg (800 IU).

While sunlight is a primary source, producing enough Vitamin D through sun exposure can be challenging due to factors like age, skin color, sunscreen use, and geographic location. Food sources are limited, making it difficult to meet needs through diet alone. Research has consistently shown that Vitamin D deficiency is common among individuals with type 2 diabetes—for whom Ozempic is approved for managing blood sugar—and those with obesity (BMI of 30 or more). This is partly because Vitamin D is fat-soluble and can get stored in body fat rather than circulating effectively in the bloodstream. If you’ve had gastric bypass surgery, your risk of low Vitamin D levels increases further.

If you have diabetes or obesity, or suspect you might not be getting enough Vitamin D while on Ozempic, we encourage you to discuss this with your healthcare professional. Our personalized approach at TrimRx emphasizes understanding your unique health profile. A blood test can accurately determine your levels, and your doctor can recommend an appropriate dosage based on your individual needs.

Vitamin A: Supporting Vision and Immunity

Vitamin A is a vital nutrient supporting healthy vision, skin, teeth, bones, and a robust immune system. It’s important to note that Vitamin A is a fat-soluble vitamin, meaning your body requires some dietary fat for its proper absorption. While Ozempic is not known to directly lower Vitamin A levels, if your reduced calorie intake leads to a very low-fat diet, you might inadvertently fall short. Most adults generally need about 700 to 900 mcg of Vitamin A daily.

Many individuals in the United States typically get sufficient Vitamin A from common foods such as orange and yellow fruits and vegetables, eggs, and dark leafy greens. If you are eating balanced meals with adequate calories—even reduced ones—you likely don’t need a specific Vitamin A supplement. However, studies do indicate that people with obesity and type 2 diabetes are more prone to having lower Vitamin A levels. Unlike water-soluble vitamins that are easily excreted, your body stores excess Vitamin A, and taking too much can be harmful. Therefore, it’s crucial to consult with your doctor before considering a Vitamin A supplement beyond what might be found in a standard daily multivitamin.

Iron: The Oxygen Carrier

Iron is a critical mineral necessary for making red blood cells and carrying oxygen throughout your body. Without enough iron, you can feel tired, weak, and experience symptoms of anemia. According to the ODS, adult males typically need 8 mg per day, while adult females under 50 require about 18 mg, decreasing to 8 mg after age 50.

Many people taking Ozempic or other GLP-1 medications may naturally eat less, and studies have occasionally found that their diets can lack important nutrients, including iron. A small study has even suggested a possible connection between initiating Ozempic treatment and reduced iron absorption. If your diet is generally rich in meat, poultry, and seafood, you probably get enough iron. However, individuals who follow vegetarian or vegan diets face an increased risk of low iron because plant-based iron (non-heme iron) is not absorbed as easily as animal-based iron (heme iron).

If you experience symptoms of low iron, such as persistent fatigue or weakness, it is important to speak with your doctor about checking your iron levels and potentially starting an iron supplement. Collaborating with a dietitian can also provide valuable guidance on dietary strategies to meet your iron needs effectively. This is part of the holistic support we champion at TrimRx, ensuring all aspects of your health are considered.

Fiber: The Digestive Ally

Constipation is a common side effect reported by individuals taking Ozempic, often exacerbated by reduced overall food intake and changes in digestive motility. Fiber, a type of carbohydrate that your body can’t digest, plays an indispensable role in maintaining digestive regularity and supporting overall gut health. It adds bulk to stool, making it easier to pass, and helps keep your digestion moving smoothly. Furthermore, adequate fiber intake is beneficial for managing blood sugar levels, which is particularly relevant for those on Ozempic.

For most adults, the recommended daily fiber intake ranges from about 22 to 34 grams, depending on age and individual needs. However, it’s important to increase your fiber intake gradually to avoid discomforts like bloating or gas. Alongside increasing fiber, drinking plenty of water is absolutely crucial, as fiber absorbs water to work effectively.

If you are diligently increasing your fiber and water intake but still experiencing constipation, consulting your doctor is advisable. They can recommend specific fiber supplements that are suitable for you, or investigate other solutions. At TrimRx, we recognize the importance of digestive wellness in your journey. Our GLP-1 Daily Support is formulated with ingredients that can contribute to overall digestive health, offering a convenient way to support your gut during this process.

Beyond Basic Nutrition: Targeted Support for Your Weight Loss Journey

While essential vitamins and minerals are foundational, optimizing your weight loss journey with Ozempic often benefits from targeted support that addresses specific physiological changes associated with rapid weight loss. These include maintaining muscle mass, supporting skin health, and managing inflammation.

Protein: Preserving Muscle and Enhancing Satiety

Protein is the fundamental building block of life, crucial for nearly every function in your body. When you are losing weight, especially at a rapid pace, ensuring adequate protein intake becomes even more critical. One of the primary concerns during significant weight loss is the potential for muscle loss alongside fat loss. Protein helps to preserve lean muscle mass, which is vital for maintaining a healthy metabolism and overall strength. Without enough protein, your body may resort to breaking down muscle tissue for energy, which is counterproductive to long-term health and weight management.

Beyond muscle preservation, protein is exceptionally effective at promoting satiety. Protein-rich foods and supplements keep you feeling fuller for longer, significantly reducing cravings and overall calorie intake. This synergistic effect—preserving muscle while curbing hunger—makes protein an indispensable nutrient for anyone on a weight loss journey with Ozempic.

Excellent sources of high-quality protein include lean meats, poultry, fish, eggs, dairy products, beans, lentils, and protein supplements. Incorporating these into your meals can make a profound difference. For convenient support, especially for those on the go, our quick-access supplements like GLP-1 Daily Support and Weight Loss Boost can assist with overall wellness and nutritional needs, providing a practical way to ensure you’re meeting your body’s demands for sustained energy and muscle support throughout your weight loss process.

Collagen: Nurturing Skin, Joints, and Connective Tissues

Collagen is the most abundant protein in the human body, serving as the primary structural component of your skin, bones, muscles, tendons, and other connective tissues. It is essentially what gives your skin its elasticity and firmness. During periods of significant or rapid weight loss, the skin may not always have enough time to retract and adjust to the new body contours, which can sometimes lead to sagging or a less firm appearance. This phenomenon has even been colloquially termed “Ozempic face” when it affects facial skin.

Supplementing with collagen can play a supportive role in mitigating these concerns. Collagen promotes skin elasticity and helps rebuild the underlying structure, potentially helping your skin remain firmer and more resilient as you lose weight. Beyond skin health, collagen also contributes to the health of your joints, which can be beneficial as your body adjusts to new activity levels and reduced weight.

When considering collagen, hydrolyzed collagen peptides are often recommended because they are broken down into smaller, more easily absorbed particles by the body. This allows for better utilization of the collagen, supporting its beneficial effects on skin and connective tissues. While a direct claim cannot be made for preventing specific aesthetic changes, supporting your body’s natural collagen production is a proactive step toward maintaining overall tissue integrity during a transformative weight loss journey.

Omega-3 Fatty Acids: Reducing Inflammation and Boosting Health

Omega-3 fatty acids are essential fats, meaning your body cannot produce them on its own and you must obtain them through diet or supplementation. They are widely recognized for their powerful anti-inflammatory properties, playing a vital role in numerous aspects of health, including cardiovascular function, brain health, and joint mobility.

As your body undergoes the significant changes associated with weight loss, especially if it’s rapid, some individuals may experience inflammation or general physical adjustments. Omega-3s can help reduce this inflammation, potentially offering protection against discomfort, supporting joint health, and even contributing to mental clarity—an aspect that can sometimes be affected during significant dietary and lifestyle changes. Furthermore, some research suggests that omega-3s may have a beneficial impact on metabolism, making them a valuable addition to a weight management strategy.

To ensure optimal results, a daily intake of 1,000-2,000 mg of combined EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid)—the two key omega-3s—is generally recommended. Excellent dietary sources include fatty fish like salmon, mackerel, and sardines, while fish oil or algal oil supplements offer a convenient way to meet these requirements, especially if dietary intake is inconsistent. Taking omega-3 supplements with food can also enhance their bioavailability and absorption. Integrating omega-3s into your daily routine provides a broad spectrum of health benefits that complement a focused weight loss program.

A Holistic Approach to Weight Loss with TrimRx

At TrimRx, we understand that true weight loss success extends far beyond a single medication or supplement. It requires a comprehensive, personalized, and supportive strategy that addresses all facets of your health and well-being. Our approach is built on this understanding, integrating medical science with empathetic care.

The Power of Personalized Care

Our vision at TrimRx began with the aim of merging cutting-edge telehealth innovations with truly effective weight loss solutions. We have cultivated a platform that is not only user-friendly but also profoundly supportive, ensuring that every individual receives personalized, medically supervised care. We firmly believe that sustainable weight loss should be achieved through science, empathy, and a transparent approach, placing your health and individual journey at the forefront.

Our brand is defined by its empathetic, innovative, trustworthy, supportive, results-oriented, and personalized nature. We are committed to offering compassionate care that respects every individual’s unique journey, combining advanced medical science with modern technology to provide you with the best possible path to success. Our commitment to transparent service means our approach remains consistent, irrespective of dosage changes. Moreover, safety is paramount; we work exclusively with FDA-registered and inspected pharmacies for the shipping of weight loss medications.

Our comprehensive service includes everything you need for a supported journey: doctor consultations, necessary lab work, the medication itself (where prescribed), unlimited support from our care team, and convenient shipping, all with no hidden fees. We offer a range of clinically proven options for our personalized weight loss program, including Compounded Semaglutide, Oral Semaglutide, Ozempic® (an FDA-approved branded medication), Compounded Tirzepatide, Oral Tirzepatide, Mounjaro® (an FDA-approved branded medication), Zepbound® (an FDA-approved branded medication), and Wegovy® (an FDA-approved branded medication). To determine your eligibility and receive a personalized treatment plan, we encourage you to take our free assessment quiz today.

Dietary Strategies to Complement Ozempic and Supplements

While supplements play a crucial role, they are most effective when integrated into a well-planned, nutrient-dense diet. A mindful dietary strategy can amplify the benefits of Ozempic and supplements alike.

Focus on whole, nutrient-dense foods: Prioritize lean proteins (such as chicken, fish, legumes), which contribute to satiety and muscle preservation. Incorporate prebiotic fibers and resistant starches (found in foods like lentils, beans, peas, oats, and cooked-and-cooled whole grains) to support gut health and potentially enhance GLP-1 production naturally. Opt for low glycemic foods that help stabilize blood sugar levels.

Managing gastrointestinal side effects: If you experience common Ozempic side effects like nausea, bland, low-fat foods (e.g., crackers, toast, rice, lean broths, gelatin) can be more easily tolerated. Limiting high-fat, spicy, or acidic foods can help prevent the exacerbation of symptoms like bloating and heartburn.

Hydration is key: Drinking plenty of water throughout the day is essential, especially when increasing fiber intake, to prevent constipation and support overall metabolic functions. Adequate hydration is also critical for general well-being and helps manage hunger cues.

By adopting these dietary strategies, you create an optimal internal environment, maximizing the effectiveness of both your medication and any supplements you choose to incorporate. This holistic perspective is central to the TrimRx philosophy: supporting your journey with robust, actionable advice.

Quick-Access Supplements for Everyday Support

In addition to our personalized prescription weight loss programs, we recognize that individuals may seek immediate support for their overall wellness journey. For those looking for convenient options to support their metabolism, energy, and digestive health without the need for a consultation, TrimRx offers quick-access supplements that do not require the personalized quiz.

Our GLP-1 Daily Support is designed to provide comprehensive daily nutritional assistance, aiding in various aspects of well-being that are beneficial during weight management. Additionally, our Weight Loss Boost is available to further support your body’s journey. These supplements are readily available for immediate purchase, offering flexible options to complement your healthier lifestyle. We believe in providing diverse tools to meet your individual needs, ensuring that supportive care is always within reach.

Safety and Professional Guidance: Your Partners in Health

Navigating your weight loss journey with Ozempic and incorporating supplements is a significant step toward a healthier life. However, it’s a path best walked with knowledgeable guidance to ensure safety and efficacy.

Always Consult Your Healthcare Provider

The paramount rule when considering any supplement alongside a prescription medication like Ozempic is to always consult with your healthcare provider first. Your doctor possesses a comprehensive understanding of your medical history, current health conditions, and all medications you are taking. This expert insight is crucial for several reasons:

  • Preventing interactions: Some supplements can interact with Ozempic or other medications you might be taking, potentially altering their effectiveness or increasing the risk of side effects. For instance, certain supplements like chromium or additional B12 might influence blood sugar regulation, necessitating adjustments to diabetes medications.
  • Assessing individual needs: What works for one person may not be suitable for another. Your healthcare provider can offer personalized advice based on your unique health profile, specific nutrient deficiencies (identified through lab tests, which are part of our comprehensive TrimRx service), and overall weight loss goals.
  • Ensuring safety: Taking too much of certain vitamins, especially fat-soluble ones like Vitamin A and D, can be harmful. Your doctor can recommend appropriate dosages to avoid toxicity.
  • Distinguishing symptoms: Some supplement side effects can mimic Ozempic side effects. Your doctor can help differentiate these and guide you on the best course of action.

Supplements to Approach with Caution

While most common vitamin and mineral supplements are generally safe to take with semaglutide, it’s prudent to be discerning. We recommend approaching supplements with artificial additives, high sugar content, or excessive stimulants with caution. These ingredients may counteract Ozempic’s beneficial effects or introduce unwanted side effects that can complicate your weight loss journey. The goal is to support your body naturally and effectively, not to introduce unnecessary complexities.

It’s also worth noting that while rare, some supplements could enhance or alter the effects of medications. If your doctor suggests certain supplements, they may advise monitoring for potential medication interactions or adjusting dosages of existing medications to ensure optimal results and safety. This diligent approach is a cornerstone of our transparent and medically supervised care at TrimRx.

Optimal Timing and Dosage

The effectiveness of supplements can sometimes be influenced by when and how you take them. For instance, fat-soluble vitamins (A, D, E, K) and omega-3 fatty acids are generally better absorbed when taken with meals that contain some fat. Protein supplements, including collagen, can be beneficial post-workout or incorporated into meals to maximize muscle recovery and satiety.

However, these are general guidelines. The most accurate and effective timing and dosage for any supplement will come from your healthcare provider. They can provide specific recommendations tailored to your regimen, ensuring you get the most benefit while maintaining safety and avoiding adverse effects. This level of personalized guidance is exactly what we strive to provide through TrimRx, ensuring that every aspect of your weight loss plan is carefully considered and supported.

Conclusion

Embarking on a weight loss journey with the support of medications like Ozempic marks a significant step toward a healthier future. As we’ve explored, Ozempic is a powerful tool, but its true potential is realized when integrated into a holistic strategy that prioritizes comprehensive nutritional support. Understanding what supplements to take with Ozempic, from essential vitamins and minerals like B12, D, A, Iron, and Fiber, to targeted aids such as Protein, Collagen, and Omega-3 fatty acids, is crucial for mitigating potential nutrient deficiencies, preserving muscle mass, supporting skin health, and promoting overall well-being. This multifaceted approach ensures that your journey is not just about shedding pounds, but about fostering a stronger, healthier, and more vibrant you.

At TrimRx, we are dedicated to making this transformative journey both accessible and effective. Our commitment shines through in our personalized, medically supervised weight loss programs, which merge innovative telehealth solutions with a foundation of science, empathy, and transparent care. We offer a comprehensive service that includes doctor consultations, necessary lab work, expertly prescribed medications (whether compounded or FDA-approved branded options), unlimited support, and convenient shipping, all without hidden fees. We partner exclusively with FDA-registered and inspected pharmacies to ensure the highest standards of safety and quality for your medications.

We encourage you to take proactive steps towards optimizing your health. Discover if our personalized weight loss program, featuring options like Compounded Semaglutide, Oral Semaglutide, Ozempic®, Compounded Tirzepatide, Oral Tirzepatide, Mounjaro®, Zepbound®, and Wegovy®, is right for you by completing our free assessment quiz today. For immediate support and to complement your journey, explore our quick-access supplements like GLP-1 Daily Support and Weight Loss Boost, available for immediate purchase.

Remember, your health journey is unique, and you don’t have to navigate it alone. With TrimRx, you gain a supportive partner, dedicated to helping you achieve safe, effective, and sustainable weight loss while prioritizing your overall health and vitality.

Frequently Asked Questions (FAQs)

Are there any supplements I shouldn’t take with Ozempic?

While most common vitamin and mineral supplements are generally safe, it’s crucial to consult your healthcare provider before starting any new supplement. You should especially avoid supplements with artificial additives, high sugar content, or excessive stimulants, as these may counteract Ozempic’s effects or cause unwanted side effects. Your doctor can check for any potential interactions with Ozempic or other medications you are taking.

How do I know if I have a nutrient deficiency while on Ozempic?

The most reliable way to determine if you have a nutrient deficiency is through blood tests ordered by your healthcare provider. Symptoms like persistent fatigue, weakness, changes in mood, hair loss, or brittle nails can be indicators, but these are non-specific. Our comprehensive service at TrimRx includes doctor consultations and lab work designed to identify any potential deficiencies and inform your personalized treatment plan.

Can I take all these recommended supplements at once?

While many supplements can be taken together, it’s essential to follow your healthcare provider’s advice on specific dosages and timing. Taking too many supplements, or excessive doses of certain fat-soluble vitamins, can sometimes lead to adverse effects or nutrient imbalances. Your doctor or a registered dietitian can help you create a safe and effective supplementation schedule tailored to your individual needs.

How does TrimRx ensure the safety of its prescribed medications and personalized plans?

At TrimRx, safety is our utmost priority. We provide medically supervised care through qualified healthcare professionals who conduct thorough consultations and review lab results to create personalized treatment plans. All prescription medications, whether compounded or FDA-approved branded options, are sourced from FDA-registered and inspected pharmacies. We emphasize transparent service, comprehensive support, and adherence to strict compliance guidelines, ensuring your weight loss journey is safe, effective, and tailored to your unique health profile.

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