TrimRx's Blog

The core difference between retatrutide and Mounjaro comes down to how many hormone targets each hits: retatrutide activates three receptors, while Mounjaro (tirzepatide) activates…

The newest weight-loss drugs work by hitting more hormone targets than GLP-1 alone, and the results suggest that more targets can mean more weight…

Amylin is emerging as the next major target in weight-loss medicine, offering a different mechanism than GLP-1 with a key advantage: gentler side effects….

The era of the weight-loss pill has arrived, and three names lead the next wave: orforglipron (already approved), amycretin, and VK2735 (both investigational). All…

Retatrutide has produced some of the largest weight loss of any drug in development, reaching roughly 24% in mid-stage trials and climbing toward 30%…

Retatrutide’s side effects are mostly the familiar gastrointestinal ones seen across weight-loss drugs, but it has one distinctive addition: a skin-tingling sensation called dysesthesia…

Viking Therapeutics is developing VK2735 in two forms, a weekly injection and a daily pill, and the practical difference comes down to convenience versus…

In its phase 2 trial, MariTide produced up to about 20% average weight loss over a year in people with obesity, and importantly, the…

Amycretin is unusual in that it’s being developed as both a daily pill and a weekly injection, and early data suggests the injection produces…